Chromosome Analyses Using Human Spermatozoa

Zenzes, Maria Teresa

doi:10.1007/978-3-642-72802-0_10

Cited by 2 publications

(2 citation statements)

References 54 publications

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“…Among those six shrews, there were homozygotes and simple Robertsonian heterozygotes, but there was no evidence for heterogeneity in the ratio of X-bearing to Y 1 Y 2 -bearing MII spreads between the samples from different individuals (P 2 (5) = 7.45; P>0.05). A survey of studies on human sperm karyotyping showed that a significant deviation from 1 : 1 ratio in sex chromosomes segregation can only be demonstrated in large samples of material (ZENZES 1987). Thus, one can conclude that the earlier studies in S. araneus give little basis for a credible evaluation of sex chromosome segregation.…”

Section: Discussionmentioning

confidence: 95%

“…Also, the analysis of almost 200 MII spreads from six simple Rb heterozygotes and homozygotes showed that sex chromosome segregation was very close to 1 : 1 (SEARLE 1986b). ZENZES (1987), who reviewed the studies on the karyotypes of human sperm pointed out that a reliable analysis of segregation of the sex chromosomes requires a large sample size of more than 200 male germ cells. Earlier studies on segregation of sex chromosomes in Sorex araneus do not meet this methodological requirement.…”

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confidence: 99%

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Sex Chromosome Meiotic Drive in Hybrid Males of the Common Shrew (Sorex araneus)

Fedyk

Bajkowska²,

Chętnicki³

2005

folia biol (krakow)

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Patterns of sex chromosome segregation in six homozygous males of the common shrew (Sorex araneus LINNAEUS, 1758) belonging to two chromosomal races, as well as in 16 interracial hybrids were studied. Based on their karyotypes the hybrids can be subdivided into two groups: (a) complex heterozygotes, which form meiotic quadrivalents in chain and chain + ring configurations, and (b) complex heterozygotes, which form meiotic pentavalents in chain configurations. Random (1 : 1) segregation of sex chromosomes was found in homozygous as well as those heterozygous males which form meiotic complexes of four chromosomes. However, in some hybrids with meiotic pentavalents we observed a strong preferential segregation in favour of X chromosomes.

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

Sex Chromosome Meiotic Drive in Hybrid Males of the Common Shrew (Sorex araneus)

Fedyk

Bajkowska²,

Chętnicki³

2005

folia biol (krakow)

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Cytogenetics of human oocytes, zygotes, and embryos after in vitro fertilization

1992

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Chromosome errors, inherited or arising de novo during gametogenesis and transmitted at fertilization to the conceptus, may be a major cause of embryonic mortality. The in vitro fertilization and embryo transfer (IVF/ET) procedure provides extra material--oocytes, zygotes, and embryos--to investigate the contribution of chromosomal abnormality to implantation failure. This paper reviews the results of cytogenetic studies on such material. Estimates from a total of 1120 oocytes from 11 studies give an overall proportion of chromosomal abnormality of 35%. Single and multiple nullisomies and disomies are found, involving nonrandom chromosome gain or loss. Hypohaploid complements are more frequent than hyperhaploid complements. The higher rate of chromosome loss of hypohaploid karyotypes was found to be largely artifactual. The estimated overall frequency of aneuploidy is 13%. In embryos the level of chromosomal abnormality is 23%-40%. Errors of fertilization are responsible for a substantial number of triploid embryos, many of which develop into mosaics. Factors extrinsic to the conceptus, such as infertility, advanced maternal age, and ovarian hyperstimulation, may increase the level of chromosomal abnormality. More refined methods for accurately recognizing and selecting chromosomally normal embryos for transfer are needed to improve the success rate of this reproductive technology.

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Chromosome Analyses Using Human Spermatozoa

Cited by 2 publications

References 54 publications

Sex Chromosome Meiotic Drive in Hybrid Males of the Common Shrew (Sorex araneus)

Sex Chromosome Meiotic Drive in Hybrid Males of the Common Shrew (Sorex araneus)

Cytogenetics of human oocytes, zygotes, and embryos after in vitro fertilization

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