Chromosome Alterations in Cleanup Workers Sampled Years after the Chernobyl Accident

Neronova, E.G.; Slozina, N M; Nikiforov, A.M.

doi:10.1667/0033-7587(2003)160[0046:caicws]2.0.co;2

Cited by 20 publications

(11 citation statements)

References 34 publications

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“…Effective doses depend on the time of arrival in the contaminated territory and the duration of exposure Snigiryova et al, 1997. Numerous studies have found that in most cases, the liquidators were exposed to low doses of ionizing radiation [Sevan,kaev et al 1995;Snigiryova et al, 1997;Moor et al, 1999;Domracheva et al, 2000;Neronova et al, 2003;Maznik and Vinnikov, 2005;Shevchenko and Snigiryova, 2006]. The current model of a threshold-free action of low-dose ionizing radiation unambiguously postulates that any level of irradiation presents a hazard.…”

Section: Discussionmentioning

confidence: 66%

“…Examination of liquidators of the accident at the Chernobyl Nuclear Power Plant (ChNPP), either shortly after or many years following their irradiation, revealed increased levels of radiation-induced chromosome aberrations in their genomes as compared to unirradiated individuals [Sevan,kaev et al, 1995;Snigiryova et al, 1997;Moor et al, 1999;Domracheva et al, 2000;Neronova et al, 2003;Maznik and Vinnikov, 2005;Shevchenko and Snigiryova, 2006]. The possible genetic consequences of the ChNPP accident (hereditary and congenital malformations, spontaneous abortions, mortinatality) were estimated not to exceed 1% of the spontaneous rate [Bochkov and Chebotarev, 1989].…”

Section: Introductionmentioning

confidence: 99%

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Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Aghajanyan

Кузьмина

Sipyagyna³

et al. 2011

Environ and Mol Mutagen

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Transgenerational genomic instability was studied in nonirradiated children born from fathers who were irradiated with low doses of ionizing radiation while working as clean-up workers at the Chernobyl Nuclear Power Plant (liquidators) and nonirradiated mothers from nuclear families. Aberrant cell frequencies (ACFs), chromosomal type aberration frequencies, and chromatid break frequencies (CBFs) in the lymphocytes of fathers-liquidators, and their children were significantly higher when compared with the control group (P < 0.05). Individual ACFs, aberration frequencies, and CBFs were independent of the time between irradiation of the father and conception of the child (1 month to 18 years). Chromosomes were categorized into seven groups (A through G). Analysis of aberrant chromosomes within these groups showed no differences in the average frequency of aberrant chromosomes between children and fathers-liquidators. However, significant differences were observed in the average frequency of aberrant chromosomes in groups A, B, and C between children and mothers in the families of liquidators. These results suggest that low doses of radiation induce genomic instability in fathers. Moreover, low radiation doses might be responsible for individual peculiarities in transgenerational genomic instability in children (as a consequence of response to primary DNA damage). Thus, genomic instability may contribute to increased morbidity over the lifetime of these children.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Aghajanyan

Кузьмина

Sipyagyna³

et al. 2011

Environ and Mol Mutagen

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“…bystander effects) (Marozik et al. , 2007) and elevated chromosome alterations (Neronova et al. , 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of parental radiation exposure on developmental instability in grasshoppers

Beasley

Bonisoli‐Alquati

Welch

et al. 2012

J of Evolutionary Biology

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Mutagenic and epigenetic effects of environmental stressors and their transgenerational consequences are of interest to evolutionary biologists because they can amplify natural genetic variation. We studied the effect of parental exposure to radioactive contamination on offspring development in lesser marsh grasshopper Chorthippus albomarginatus. We used a geometric morphometric approach to measure fluctuating asymmetry (FA), wing shape and wing size. We measured time to sexual maturity to check whether parental exposure to radiation influenced offspring developmental trajectory and tested effects of radiation on hatching success and parental fecundity. Wings were larger in early maturing individuals born to parents from high radiation sites compared to early maturing individuals from low radiation sites. As time to sexual maturity increased, wing size decreased but more sharply in individuals from high radiation sites. Radiation exposure did not significantly affect FA or shape in wings nor did it significantly affect hatching success and fecundity. Overall, parental radiation exposure can adversely affect offspring development and fitness depending on developmental trajectories although the cause of this effect remains unclear. We suggest more direct measures of fitness and the inclusion of replication in future studies to help further our understanding of the relationship between developmental instability, fitness and environmental stress.

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“…The examination of liquidators of the accident at the ChNPP, either shortly after or many years following their irradiation, revealed increased levels of radiation-induced chromosome aberrations in their genomes as compared to unirradiated individuals (Sevankaev et al 1995;Snigiryova et al 1997;Domracheva et al 2000;Neronova et al 2003;Maznik et al 2003;Shevchenko and Snigireva 2006). In liquidators, a significant increase in incidence of solid cancers (Kashcheev et al 2015) with a latent period between 4 and 15 years is described (Ivanov et al 2009a, b).…”

Section: Unirradiated Children Born From Irradiated Parentsmentioning

confidence: 99%

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

et al. 2016

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As children are more susceptible to ionizing radiation than adults, each nuclear accident demands special attention and care of this vulnerable population. The Chernobyl nuclear disaster occurred in a region populated with a large number of children, but despite all efforts and expertise of nuclear specialists, it was not possible to avoid casualties. As vast regions of Ukraine, Belarus and Russia were exposed to doses of ionizing radiation, which are known to be related with different diseases, shortly after the accident medical surveillance was launched, which also included analysis of genome damage. Child population affected by internal and external radiation consisted of subjects exposed prenatally, postnatally (both evacuated and non-evacuated), born by irradiated fathers who worked as liquidators, and parents exposed environmentally. In all groups of children during the last 30 years who were exposed to doses which were significantly higher than that recommended for general population of 1 mSv per year, increased genome damage was detected. Increased genome damage includes statistically higher frequency of dicentric and ring chromosomes, chromated and chromosome breaks, acentric fragments, translocations, and micronuclei. The presence of rogue cells confirmed internal contamination. Genome instability and radiosensitivity in children was detected both in evacuated and continuously exposed children. Today the population exposed to ionizing radiation in 1986 is in reproductive period of life and follow-up of this population and their offspring is of great importance. This review aims to give insight in results of studies, which reported genome damage in children in journals without language restrictions.

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Chromosome Alterations in Cleanup Workers Sampled Years after the Chernobyl Accident

Cited by 20 publications

References 34 publications

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Analysis of genomic instability in the offspring of fathers exposed to low doses of ionizing radiation

Effects of parental radiation exposure on developmental instability in grasshoppers

Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident

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