Chromosome abnormalities in peripheral T‐cell lymphoma

Abstract

We have studied neoplastic lymph nodes from six patients histologically, immunologically and cytogenetically. Histologically all the cases were classified as peripheral T-cell lymphomas. These were subclassified as T-zone lymphomas in three, large cell 'pale cell' variant in one, large cell immunoblastic in one, and small cell, mycosis fungoides in one. Two had features of angioimmunoblastic lymphadenopathy (AILD). Immunologically all cases expressed CD2 (OKT11) and CD4 (T4). All six cases had clonal chromosome abnormalities, although in four cases the majority of cells were chromosomally normal. Chromosome 3 was most often involved in abnormalities, occurring in five patients. The most common single chromosome abnormality, trisomy 3, was seen in all three cases classified as T-zone lymphoma and in no other cases. In the two cases with features of AILD only numerical abnormalities were seen, whereas in the other cases complicated structural rearrangements were present. Recurring structural abnormalities involved bands 1p12or13, 1q32, 3p25 and 14q11. Our data suggest that cytogenetic analysis may assist in diagnosis and classification of the peripheral T-cell lymphomas.

Immunohistochemical, molecular, and cytogenetic analysis of a consecutive series of 20 peripheral t‐cell lymphomas and lymphomas of uncertain lineage, including 12 Ki‐I positive lymphomas

“…Other abnormalities observed in the present study included rearrangements affecting both arms of chromosomes 1,2, and 6, and the long arm of chromosome 14. These results are similar to those previously published in non-B-cell lymphomas (Lakkala-Paranko et al, 1987;Berger et al, 1988;Kaneko et al, 1989;Le Beau et al, 1989;Rimokh et al, 1989). Of interest is our finding that PTCLs and LULs do not differ markedly in the types of abnormalities displayed by their chromosomes.…”

Diagnosis of Small Non–cleaved Cell Lymphoma by Fine Needle Aspiration Utilizing Cytomorphologic Features Combined with Cytogenetic Analysis

“…Cytogenetic studies can be successfully performed on fine needle aspirate material and may be helpful in the identification and subclassification of malignant lymphoma, 4,12,13,18,20 particularly small non-cleaved cell. In this paper we report the results of four cases of small non-cleaved cell lymphoma diagnosed from FNA material by combining cytomorphology with cytogenetic analysis for a definitive diagnosis.…”

“…Schmitz, Beneke and Kubic 4,12,13,18,20 The feasibility of obtaining successful karyotypes from fine needle aspirate material has been previously described. 1,5,8,9 In one study, 118 samples obtained by FNA from 86 cases of non-Hodgkin's, non-Burkitt lymphoma were karyotyped.…”

Cytogenetic abnormalities and clinical correlations in peripheral T‐cell lymphoma

“…Compared to the B-cell lymphoma, peripheral T-cell lymphoma (PTCL) is a relatively rare disease in the western hemisphere (Lakkala-Paranko et al, 1987; The Fifth International Workshop on Chromosomes in Leukemia-Lymphoma., 1987;Armitage et al, 2004). PTCLs can be further categorized into angioimmunoblastic T-cell lymphoma (AITL), anaplastic large cell (ALCL), and peripheral T-cell lymphoma, unspecified (PTCL-US), as well as a number of rare subtypes (Jaffe et al, 2001).…”