Chromosome Aberrations in Lymphocytes From Patients Exposed to Thorium Dioxide

Frequencies of chromosome aberrations in peripheral blood lymphocytes from 63 Thorotrast patients were analysed basing on the age distribution of lymphocytes. The frequency and distribution of chromosome aberrations among lymphocytes are best explained if we assume that the lymphocytes are renewed as an exponential function of time and spend most of their lifetime in the distributive pool where, while exchange of lymphocytes is taking place, the lymphocytes are hit by alpha-particles from Thorotrast aggregates resulting in the formation of chromosome aberrations and killing at specific rates per hit. The model predicts that the aberration frequency is rather insensitive to the fluence rate because of modulation by cell killing by hit. Fitting the observed data to the model showed that approximately 0.8 dicentrics and rings were produced by a single path of alpha-particle and average fluence rate to lymphocytes in a group of patients with the highest aberration frequency was estimated to be about 1.5 hits or 87 rad/lymphocyte/year.

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Chromosome aberration frequency and radiation dose to lymphocytes by alpha-particles from internal deposit of Thorotrast

Sasaki

Takatsuji

Ejima

et al. 1987

Radiat Environ Biophys

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Thorotrast‐induced Haemangioendothelial Sarcoma—A Lesson from the Past

Mf¹,

Scopa²

1976

Australian and New Zealand Journal of Medicine

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Complications following a carotid arteriogram done in 1947 with Thorotrast are described in a 47-year-old man who subsequently died from them in 1970. They included a local cervical granuloma with associated haemangioendothelial sarcoma, chromosome changes characteristic of radiation damage and widespread haemangioendothelial sarcomatous deposits in brain, lung, liver, probably arising from multicentric primary sites in the bone marrow. A survey of the use of Thorotrast as a contrast medium in Australia and New Zealand showed that its use was extremely limited. The prinicpal complications seen have been two cervical granulomas and one hepatoma.

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A Bibliography on the Toxicology of Vinyl Chloride and Polyvinyl Chloride

Heimann

Lilis

Hawkins³

1975

Annals of the New York Academy of Sciences

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Chromosome Aberrations in Lymphocytes From Patients Exposed to Thorium Dioxide

Cited by 4 publications

References 8 publications

Chromosome aberration frequency and radiation dose to lymphocytes by alpha-particles from internal deposit of Thorotrast

Chromosome aberration frequency and radiation dose to lymphocytes by alpha-particles from internal deposit of Thorotrast

Thorotrast‐induced Haemangioendothelial Sarcoma—A Lesson from the Past

A Bibliography on the Toxicology of Vinyl Chloride and Polyvinyl Chloride

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