Chromosome aberrations in employees from fossil-fueled and nuclear-power plants

Léonard, A.; Deknudt, Gh.; Léonard, Évelyne; Decat, G.

doi:10.1016/0165-1218(84)90045-4

Cited by 39 publications

(9 citation statements)

References 9 publications

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“…In the present study, the observed increase of DNA damage level in workers in terms of tail intensity were consistent with the previous cytogenetic studies [17,23,24] reported the genotoxic risks in the workers occupationally exposed to chemical products of burning coal and ashes. Elevated level of DNA damage might originate from the many chemical compounds present in the coal ash and also in the gaseous emissions.…”

Section: Resultssupporting

confidence: 95%

“…In another study, Leonard et al [17], reported a significant increase in acentric chromosome fragments and dicentric chromosome as well as the number of abnormal cells in workers from coal fueled power plant as compared to control group. Beside, Celik at al.…”

Section: Resultsmentioning

confidence: 95%

“…A few studies concerning the genotoxic risks of workers occupationally exposed to coal combustion products in power plants, reported a significant increase in the level of chromosomal aberrations (CA), in acentric chromosome fragments and dicentric chromosome as well as the number of abnormal cells, sister chromatid exchanges (SCE), micronucleus (MN), and polyploid cells in workers as compared to control group [16,17].…”

Section: Introductionmentioning

confidence: 99%

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DNA hazard in Furnace Operating Workers from a Power Plant

T¹,

Durmaz²,

OK³

et al. 2011

J Carcinogene Mutagene

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The aim of this study was to investigate the possible DNA damage in workers occupationally exposed to coal combustion products in furnace section of Afsin-Elbistan A power plant (Turkey). With this purpose, venous blood samples collected from 36 male power plant workers were analysed by comet assay for determining the level of DNA tail intensity. The obtained results were compared with those of control group consisting of 34 healthy male individuals. The data comparison showed that mean frequency of tail intensity was significantly higher in workers as compared to control group (P<0.05), respectively 9.94±2.51 and 8.48±2.31. Present study indicated the DNA damage in the peripheral lymphocytes of furnace operators, possibly due to the several chemical compounds present in the coal ash and gaseous emissions.

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Section: Resultssupporting

confidence: 95%

Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

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DNA hazard in Furnace Operating Workers from a Power Plant

T¹,

Durmaz²,

OK³

et al. 2011

J Carcinogene Mutagene

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“…Hazards caused by coal and derivatives have been de- scribed by many authors using bacterial [Whong et al, 1983;Kleinjans et al, 1989] and human cells [Léonard et al, 1984;Srám et al, 1985;Kleinjans et al, 1989;Stierum et al, 1993]. For human cells, different techniques have been utilized, such as sister-chromatid exchange, hprt expression, chromosomal abnormalities, and micronucleus.…”

Section: Discussionmentioning

confidence: 99%

Genotoxicity biomonitoring in coal regions using wild rodentCtenomys torquatus by Comet assay and micronucleus test

Silva

Freitas

Heuser

et al. 2000

Environ. Mol. Mutagen.

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Coal is a mixture of a variety of chemicals, especially hydrocarbons, which may give rise to polycyclic aromatic hydrocarbons (PAH). Many PAH compounds produce mutagenic and carcinogenic effects. The quality of mineral coal in Rio Grande do Sul (RS) is low and it is typically obtained by stripping operations; it represents approximately 87% of the Brazil reserves. This report concerns the application of the Comet assay to Ctenomys torquatus to detect the effects of coal, comparing the results with a micronucleus (MN) assay, both using peripheral blood. This study was performed over a 2‐year period in an attempt to evaluate seasonal patterns. The wild rodent is fossorial, and its geographic distribution in RS coincides with the distribution of coal reserves. Three localitions were studied: two coal fields, Butiá (in a strip coal mine region) and Candiota (near a strip coal mine), and one control region, Pelotas (no coal). At the end of 2 years, 240 rodents had been analyzed. Our results showed that coal and derivatives induced DNA and chromosomal lesions in rodent cells that were demonstrated by Comet and MN assays. These tests also demonstrated quantitative differences between field exposures (Candiota > Butiá). The Comet assay was more sensitive and also showed a direct relationship between age and damage, and an inverse relationship between temperature and damage index. Environ. Mol. Mutagen. 35:270–278, 2000 © 2000 Wiley‐Liss, Inc.

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“…Leonard et al (1984) analyzed chromosome aberrations in 59 workers of coal-fueled power plants and 89 workers of nuclear power plants and reported a significant elevation in acentric fragments and dicentric chromosomes in both types of workers compared with the control group. These reports largely attribute the elevated frequencies to occupational exposure to low doses of ionizing radiation and smoking.…”

Section: Resultsmentioning

confidence: 99%

Chromosome aberrations in workers of beach sand mineral industries

Meenakshi

Mohankumar

2013

Radioprotection

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Beach Sand Mining (BSM) is a profitable industry earning a sizable income for thecountry by way of foreign exchange. The Indian coast is rich in rare earths such as ilmenite, rutile, leucoxene, zircon, garnet and sillimanite, and is invariably associated with radioactive monazite. Due to the nature of the separation processes involved and the manual handling, workers in these factories are continuously being exposed to suspended particles containing naturally occurring radioactive materials. An attempt was made to estimate DNA damage using a chromosome aberration assay to monitor radiation effects in workers of BSM industries in India. The study group comprised 27 BSM workers and 20 controls. Percentage yields of dicentrics, acentric fragments and chromatid breaks observed in the control group were 0.058 ± 0.017, 0.073 ± 0.03 and 0.22 ± 0.112, respectively. Percentage yields of dicentrics + centric rings, acentric fragments and chromatid breaks observed in the BSM group were 0.029 ± 0.01 (P value 0.19), 0.24 ± 0.06 (P value 0.006) and 0.455 ± 0.06 (P value 0.0004), respectively. Elevated levels of fragments and chromatid aberrations are suggestive of low-dose radiation effects and also chemically-induced DNA damage.

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Chromosome aberrations in employees from fossil-fueled and nuclear-power plants

Cited by 39 publications

References 9 publications

DNA hazard in Furnace Operating Workers from a Power Plant

DNA hazard in Furnace Operating Workers from a Power Plant

Genotoxicity biomonitoring in coal regions using wild rodentCtenomys torquatus by Comet assay and micronucleus test

Chromosome aberrations in workers of beach sand mineral industries

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