Chromosome 7 Gain Compensates for Chromosome 10 Loss in Glioma
Nishanth Ulhas Nair,
Alejandro A. Schäffer,
E. Michael Gertz
et al.
Abstract:The co-occurrence of chromosome 10 loss and chromosome 7 gain in gliomas is the most frequent loss-gain co-aneuploidy pair in human cancers. This phenomenon has been investigated since the late 1980s without resolution. Expanding beyond previous gene-centric studies, we investigated the co-occurrence in a genome-wide manner taking an evolutionary perspective. Mining of large-scale tumor aneuploidy data confirmed the previous finding of a small-scale longitudinal study that the most likely order is chromosome 1… Show more
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