Chromosome-11q13 Gene Amplifications in Head and Neck Squamous-Cell Carcinomas - Relation With Lymph-Node Invasion

Parise, Orlando; Janot, F.; Guerry, R; Fortin, A.; Luboinski, B.; Tursz, T; Schwaab, G; Busson, P.

doi:10.3892/ijo.5.2.309

Cited by 7 publications

(7 citation statements)

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“…In breast c cyclin Dl has been related to poor prog 1992b). When studying squamous cell car neck, amplification of cyclin Dl was asso( involvement and an increased likelihood (Muller et al, 1994;Parise et al, 1994; Mi bladder cancer, pRb and various cell cycle to be involved in tumour development ar 1991;Sakis et al, 1993). Furthermore, an some 1 q13 has also been found in bladdi Proctor et al, 1991; Bringu findings suggest that alterations of cyclin role in the development of bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Amplification of cyclin Dl appears to be correlated with poor prognosis in breast carcinoma (Schuuring et al, 1992b), with lymph node involvement and recurrence in head and neck squamous cell carcinoma (Muller et al, 1994;Parise et al, 1994;Michalides et al, 1995). Although amplification of the 1 q13 region has been observed in bladder carcinoma, the prognostic significance of cyclin Dl overexpression has not been yet reported in bladder carcinoma.…”

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Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

Shin

Kong²,

Kim³

et al. 1997

Br J Cancer

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Summary Cyclin Dl is a cell cycle regulator essential for G1 phase progression and is frequently overexpressed in several human tumour types as a consequence of gene amplification or chromosomal rearrangements. We analysed the expression of cyclin Dl in 75 patients with transitional cell carcinoma (TCC) to investigate the possible relationship between its expression and clinical outcome as well as histopathological findings using the immunohistochemical method. We observed strong staining (++, > 50% positive cells) for cyclin Dl in 19 cases (25.3%) and weak staining (+, 5-50% positive cells) in 19 cases (25.3%). Overexpression of cyclin Dl was not associated with tumour invasion. No significant association was found between overexpression of cyclin Dl and tumour grade (P > 0.05). We assessed the differences of disease-free interval in superficial tumours and actuarial survival probability in invasive tumours according to the status of cyclin Dl expression. Tumours with (++) staining for cyclin Dl recurred much more rapidly than (-) and/or (+) staining tumours (P < 0.01 for -vs ++; P < 0.05 for + vs ++). However, overexpression of cyclin Dl was not associated with a shortened overall survival of patients with invasive tumours (P< 0.1). These results suggest that genetic alteration of cyclin Dl appears to be an early event in the tumorigenesis of bladder TCC and is associated with early recurrence in superficial tumours.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

Shin

Kong²,

Kim³

et al. 1997

Br J Cancer

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“…In summary, some of the important HPV transformation biomarker features found in many oral carcinomas are the subtypes (e.g., 16/18 or 30/57) (Broker and Botchan, 1986) and associations with chromosome regions 3p (e.g., 3pl4.2), 6p (e.g., 6p2l.1-22.3) (Mullokandov et al, 1996), and l I q (e.g., 11q 1 3, 22-24). Some sites of 3p and 6p have been linked to the loss of heterozygosity (LOH), while 1 1q13 has been linked to cyclin Dl activity (Smits et al, 1990;Hampton et al, 1994;El-Deiry et al, 1995;Parise et al, 1994;Steernbergen et al, 1995).…”

Section: (D) the Use Of Archival Biopsy Materialsmentioning

confidence: 99%

Biomarkers and Molecular Epidemiology and Chemoprevention of Oral Carcinogenesis

Schwartz

2000

Critical Reviews in Oral Biology & Medicine

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Chemopreventives are chemicals that prevent the formation of cancers such as oral cancer. They can take the form of nutrients or synthetic molecules, and their fundamental characteristic is that they do not produce disease processes that would result in debilitating symptoms. Current evidence indicates that they function by modifying the oxidative state of transforming cells. Biomarkers can take the form of genetic and molecular indicators, which characterize the function of chemopreventives and cancer processes such as oral carcinogenesis. Biomarkers cannot provide all the required information for risk assessment or possible activity of the chemopreventives. Other methods, such as epidemiological analyses and techniques, must be used to enhance our understanding of the risk for oral cancer in human populations. One common epidemiologic method, the questionnaire, helps to determine the use and carcinogenic potential of tobacco and alcohol during oral carcinogenesis. Genetic and molecular changes in human patient populations may result in a reduction in the number and function of tumor suppressor genes. If these changes are to be assessed, the tissues (e.g., buccal mucosa) must be accessible and harvested in a reliable and consistent manner for the acquisition of DNA, mRNA, and protein. Oral tissues provide sufficient quantities of these molecules and, under stringent conditions, the quality required for the isolation of these molecular constituents. In conjunction with epidemiologic techniques, various genotypic polymorphisms, such as glutathione-S-transferase (GSTM 1) or cytochrome P450 (CYP450Al), have indicated a loss in carcinogen detoxification or the processing of internal growth control signals. Biomarkers are composed of a large diverse group of genetic and molecular structures. Some of these biomarkers are indicators for programmed cell death (PCD), while others describe malignant tumor growth. Many of these classes of molecules are oxidative-responsive (e.g., tumor suppressor p53, Bcl-2, growth factors, immune-derived proteins, and death-inducing molecules) and induce PCD by triggering a cascade of cysteine proteases and regulators (e.g., caspases, death receptors). This pathway results in cell-cycle alterations and DNA fragmentation. It is hoped that a detailed knowledge of the processes involved in malignant transformation will better define the biomarker-screening tools for oral cancer. These tools will enhance our ability to predict the incidence of cancer, detect early malignant change, and quantitate chemoprevention during oral carcinogenesis. Chemopreventives such as the retinoids have already demonstrated their ability to suppress potential malignant changes in pre-malignant oral leukoplakias and decrease the incidence of second head-and-neck cancer primaries. It is our hope that this review will increase investigators' interest in developing new screening and detection systems for oral cancer.

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“…Studies of HNSCC concerning amplification of the chromosome 11q13 region, where the cyclin D1 and EMS-1 genes are harbored, indicated a relation of this amplification with the development of nodal metastasis. 11,[33][34][35][36][37] The relation between lymph node metastasis and the expression of cyclin D1 has not been studied frequently. In examining the expression of cyclin D1 with immunohistochemistry, Michalides et al 38 found no correlation of cyclin D1 expression with N stage; however, other authors did.…”

Section: Commentmentioning

confidence: 99%

Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer

Takes¹,

Jong²,

Alles³

et al. 2002

Arch Otolaryngol Head Neck Surg

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The expression of the investigated genetic markers and histopathological features of primary tumors can supply limited information on the metastatic behavior of tumors. Although the use of markers for regional metastasis would be a welcome additional tool, these results do not warrant the use of these parameters for clinical decision making concerning the treatment of the neck in patients with head and neck squamous cell cancer.

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Chromosome-11q13 Gene Amplifications in Head and Neck Squamous-Cell Carcinomas - Relation With Lymph-Node Invasion

Cited by 7 publications

References 0 publications

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers

Biomarkers and Molecular Epidemiology and Chemoprevention of Oral Carcinogenesis

Markers for Nodal Metastasis in Head and Neck Squamous Cell Cancer

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