Chromosomal radiosensitivity in patients with common variable immunodeficiency

Aghamohammadi, Asghar; Moin, Mostafa; Kouhi, Ali; Mohagheghi, Mohammad Ali; Shirazi, Alireza; Rezaei, Nima; Tavassoli, Sanaz; Esfahani, Mahbod; Cheraghi, Taher; Dastan, Jila; Nersesian, Jeanet; Ghaffari, Saeed Reza

doi:10.1016/j.imbio.2007.10.018

Cited by 50 publications

(31 citation statements)

References 40 publications

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“…Several studies have shown that increased radiosensitivity of lymphocytes and aberrancies in DNA-repair genes can be found in some CVID patients. [40][41] Therefore, we are currently investigating DNA-repair defects in CVID patients with this B-cell pattern. Other defects that affect precursor B-cell development are potentially involved in the pathophysiology of B-cell pattern 1.…”

Section: Discussionmentioning

confidence: 99%

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

Driessen

Zelm

Hagen

et al. 2011

Blood

103

108

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Section: Discussionmentioning

confidence: 99%

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

Driessen

Zelm

Hagen

et al. 2011

Blood

103

108

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“…Findings such as bronchial dilatation, signet ring sign (large airway involvement), tree-in-bud sign (small airway involvement), mucopurulent plugs, bronchial wall thickening, lack of tapering, and bronchi visible closer than 2 cm to the pleural surface are considered characteristic of bronchiectasis [92]. Since we and others demonstrated that patients with DNA repair defects and some CVID patients show increased radiation sensitivity [93][94][95], a radiation-free alternative to CT scan or chest X-ray could be magnetic resonance imaging to assess pulmonary changes and alterations [96]. Recognizing the cause of bronchiectasis may improve management and prognosis, eg, initiation of immunoglobulin replacement in PAD patients, which may prevent the progression of irreversible lung damage.…”

Section: Bronchiectasismentioning

confidence: 99%

Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

Yazdani

Abolhassani

et al. 2017

J Investig Allergol Clin Immunol

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Primary immunodeficiency disorders (PIDs) are caused by 1 or more defects of the immune system. Patients are more likely to experience recurrent and/or severe infections and tend to develop a wide range of complications. Respiratory diseases are the main and initial manifestation in most cases and the most common complication. Pulmonary complications cause significant morbidity and mortality in patients with PIDs. Early diagnosis and appropriate treatment can prevent or at least slow the development of respiratory complications. Since the spectrum of pulmonary complications in PIDs is broad, we divided pulmonary complications into upper respiratory complications (eg, sinusitis, otitis media, and laryngeal angioedema) and lower respiratory complications (eg, pneumonia, bronchitis, bronchiectasis, interstitial lung diseases, organizing pneumonia, pulmonary adenopathies and malignancies, hyperreactive airway diseases, pulmonary dysgenesis, and adverse reactions to treatment). This review covers the main respiratory manifestations in patients with PIDs. Key words: Primary immunodeficiency disorders. Pulmonary complications. Upper respiratory tract. Lower respiratory tract. ResumenLas inmunodeficiencias primarias (PIDs) son enfermedades causadas por uno o más defectos del sistema inmunológico. Estos pacientes presentan con frecuencia infecciones recidivantes y/o severas así como otro tipo de complicaciones. Las patologías respiratorias son la principal y más frecuente manifestación y complicación de las PIDs. Las complicaciones de estas patologías pulmonares constituyen una de las principales causas de morbimortalidad entre los pacientes que sufren PIDs. El diagnóstico temprano y el tratamiento adecuado pueden prevenir, o al menos retrasar, la aparición de las complicaciones respiratorias en estos pacientes. Dado que el espectro de las enfermedades pulmonares es muy amplio, hemos dividido estas complicaciones entre aquellas que afectan a las vías aéreas superiores (sinusitis, otitis media y angioedema laríngeo, etc.) y las que afectan a las vías aéreas bajas (neumonía, bronquitis, bronquiectasias, enfermedades pulmonares intersticiales, neumonía organizada, adenopatías pulmonares y neoplasias, hiperreactividad bronquial, disgenesia pulmonar y las debidas a los efectos secundarios del tratamiento instaurado). Este artículo revisa las manifestaciones respiratorias que se observan más frecuentemente en los pacientes con PIDs. Palabras clave: Inmunodeficiencias primarias. Complicaciones pulmonares. Vías respiratorias altas. Vías respiratorias bajas.

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“…Plain chest X-ray radiography is of limited value in CVID; however, it should be considered if the patient is febrile, has pleuritic pain and signs of consolidation, effusion or collapse. Moreover, because of the probability of radiosensitivity in some CVID cases, lower intervals with other X-ray procedures should be avoided as screening leads to excessive radiation exposure over time [48,51,[100][101][102]. Biopsy and pathological investigation should be carried out if large or persistent nodules are found in the lungs, which may change our therapeutic strategy to treat for polyclonal lymphocytic infiltrative disease-like granulomatous infiltrates [53,103].…”

Section: Follow-upmentioning

confidence: 99%

A review on guidelines for management and treatment of common variable immunodeficiency

Abolhassani

Sagvand

Shokuhfar

et al. 2013

Expert Review of Clinical Immunology

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Chromosomal radiosensitivity in patients with common variable immunodeficiency

Cited by 50 publications

References 40 publications

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

B-cell replication history and somatic hypermutation status identify distinct pathophysiologic backgrounds in common variable immunodeficiency

Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders

A review on guidelines for management and treatment of common variable immunodeficiency

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