Chromosomal localization of the human hexabrachion (tenascin) gene and evidence for recent reduplication within the gene

Tenascin-C: Form versus function

“…23,174 Analysis of the human tenascin-C cDNA sequence revealed a cluster of 10 potential N-linked glycosylation sites within the alternatively spliced FNIII repeats A1-A4, within 2 clusters given as NLT-X 11 -NWT-X 23 -NLT-X 63 -NWT-X 23 -NLT. Three further putative N-glycosylation sites were identified in human FNIII B, 19,23 and further analysis with the NetNGlyc 1.0 Server revealed 4 more predicted N-glycosylation sites in the FNIII AD1 and AD2 domains. 174 In chicken tenascin-C, 17 potential N-glycosylation sites were identified by gene analysis, 6 of which were located in the FNIII AD1 and AD2 domains.…”

“…The tenascin-C gene (TNC) is a large intron rich gene, which in humans spans 97.68 kb of DNA on the antisense strand of chromosome 9, at locus 9q32-34/9q33.1 19,20 and of which only »7.9% is protein coding (reviewed in 21 ). The first partial gene sequence derived for chicken tenascin-C identified several transcripts of various lengths prompting the speculation that the transcript is alternatively spliced.…”

Report of the committee on the genetic constitution of chromosome 9

“…A,L,R,S c Brook-Carter et al, 1991Rocchi et al, 1991bGulcher et al, 1990 9q33 C5 complement component 5 A,R,S c Harris et al, 1991Jeremiah et al, 1988Wetscl et al, 1988Jeremiah et al, 1987 9q33 GSN + gelsolin A,CH,L,S c Leversha et al, 1991Harris et al, 1991Ghisoet al, 1990Levy et al, 1990Kwiatkowski et al, 1989Kwiatkowski et al, 1988 9q33-q34 D9S26 + DNA Segment, single copy probe CRI-L659 L c Ozelius et al, 1991Donis-Keller et al, 1987 9q33-q34 GLYT2 glycosyltransferase 2 (UDP galactose: betagalactosyl(l ,4)-N-acetyl-glucose alpha( 1, 3)galactosyltransferase -symbol provisional Hanish et al, 1991Heisterkamp et al, 1988Chan et al, 1987Jhanwar et al, 1984Groffen et al, 1984de Klein et al, 1982Heisterkamp et al, 1982 9q34.1 AK1 + adenylate kinase 1 A,D,S C Leversha et al, 1991Harris et al, 1991Mattei et al, 1984Cook et al, 1978 ASS + argininosuccinate synthetase A,L,R,S C Kwiatkowski et al, 1991aHarris et al, 1991Yuille et al, 1990Northrup et al, 1989Su et al, 1984Beaudet et al, 1982Carritt et al, 1977 Leversha et al, 1991Harris et al, 1991Birkenmeier et al, 1988Barton et al, 1987McMahon et al, 1987 ABO C ABO blood group L C Yamamoto et al, 1990a…”

Report of the committee on the genetic constitution of chromosome 9

“…A new assignment to 9q34 is HXB (Gulcher et al, 1990) which codes for a large extracellular matrix glycoprotein which may be involved in cell adhesion. It has been described under several names, but is most commonly called either tenascin or hcxabrachion.…”