Chromosomal localization of the human histamine H1-receptor gene

Coniat, Maryvonne Le; Traiffort, Élisabeth; Ruat, Martial; Arrang, Jean‐Michel; Berger, R.

doi:10.1007/bf00202867

Cited by 32 publications

(20 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This led rapidly to the cloning of the receptor cDNA in several species, including human in 1993(De Backer et al, 1993Moguilevsky et al, 1994). The human gene was subsequently localized to chromosome 3p14-p21 (Le Coniat et al, 1994). A single H 1 receptor polymorphism rs7651620 Glu270Gly has been identified that is relevant to African subjects only (Garcia-Martin et al, 2009;Micallef et al, 2013).…”

Section: A Receptor Structurementioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

et al. 2015

View full text Add to dashboard Cite

Section: A Receptor Structurementioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors

et al. 2015

View full text Add to dashboard Cite

“…All of these receptors belong to the G protein-coupled receptor family. They are heptahelical transmembrane molecules that transduce extracellular signals by using G proteins and intracellular second messenger systems [10, 13]. The active and inactive states of HRs exist in equilibrium.…”

Section: Histamine Receptorsmentioning

confidence: 99%

Histamine in Allergic Inflammation and Immune Modulation

Jutel¹,

Blaser²,

Akdiş³

2005

Int Arch Allergy Immunol

117

View full text Add to dashboard Cite

Histamine, originally considered as a mediator of acute inflammatory and immediate hypersensitivity responses has also been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. On the other hand, various cytokines control histamine synthesis, release and expression of histamine receptors (HRs). The cells involved in the regulation of immune response and hematopoiesis express HRs and also secrete histamine, which can selectively recruit the major effector cells into tissue sites and affect their maturation, activation, polarization and effector functions leading to chronic inflammation. Histamine, acting through its receptor type 2, positively interferes with the peripheral antigen tolerance induced by T regulatory cells in several pathways. Histamine also regulates antigen-specific Th1 and Th2 cells, as well as related antibody isotype responses. The diverse effects of histamine on immune regulation are due to differential expression and regulation of four HRs and their distinct intracellular signals. In addition, differences in affinities of these receptors are highly decisive on the biological effects of histamine and agents that target HRs. This article highlights the findings leading to a change of perspective in histamine immunobiology.

show abstract

“…There are four major types of histamine receptors: H1, H2, H3 and H4 receptors which differ in their expression, signal transduction and function (38)(39)(40)(41)(42)(43)(44)(45). Exspression of H1 and H2 receptors are widely expressed in contrast to H2 and H4 receptors.…”

Section: Hi St a M I Ne Re Ce P T Orsmentioning

confidence: 99%