Chromosomal intrachanges induced by swift iron ions

Horstmann, M.; Durante, Marco; Johannes, Christian; Obe, G.

doi:10.1016/j.asr.2004.12.031

Cited by 8 publications

(1 citation statement)

References 28 publications

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“…For detection of reciprocal translocations, multicolor fluorescence in situ hybridization (mFISH) was first applied to members of the Mir-18 crew [112]. In search of a specific marker of heavy ion exposure, complex chromosome interchanges were suggested and analyzed in blood lymphocytes of astronauts [113,114]. High-resolution multicolor banding (mBAND) of chromosome 5 can visualize intrachromosomal exchanges-long-term missions to the ISS did not increase this parameter [115].…”

Section: Chromosomal Aberrations and Biodosimetrymentioning

confidence: 99%

Space Radiobiology

Hellweg,

Arena,

Baatout

et al. 2023

Radiobiology Textbook

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The study of the biologic effects of space radiation is considered a “hot topic,” with increased interest in the past years. In this chapter, the unique characteristics of the space radiation environment will be covered, from their history, characterization, and biological effects to the research that has been and is being conducted in the field.After a short introduction, you will learn the origin and characterization of the different types of space radiation and the use of mathematical models for the prediction of the radiation doses during different mission scenarios and estimate the biological risks due to this exposure. Following this, the acute, chronic, and late effects of radiation exposure in the human body are discussed before going into the detailed biomolecular changes affecting cells and tissues, and in which ways they differ from other types of radiation exposure.The next sections of this chapter are dedicated to the vast research that has been developed through the years concerning space radiation biology, from small animals to plant models and 3D cell cultures, the use of extremophiles in the study of radiation resistance mechanisms to the importance of ground-based irradiation facilities to simulate and study the space environment.

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Section: Chromosomal Aberrations and Biodosimetrymentioning

confidence: 99%

Space Radiobiology

Hellweg,

Arena,

Baatout

et al. 2023

Radiobiology Textbook

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Radiation in Space: The Biology

Hellweg

Matthiä

Berger

et al. 2020

SpringerBriefs in Space Life Sciences

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Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts’ lymphocytes

Horstmann

Durante

Johannes

et al. 2005

Radiat Environ Biophys

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Chromosome aberration analysis in astronauts has been used to provide direct, biologically motivated estimates of equivalent doses and risk associated to cosmic radiation exposure during space flight. However, the past studies concentrated on measurements of dicentrics and translocations, while chromosome intrachanges (inversions) have never been measured in astronauts' samples. Recent data reported in the literature suggest that densely ionizing radiation can induce a large fraction of intrachanges, thus leading to the suspicion that interchanges grossly underestimate the cosmic radiation-induced cytogenetic damage in astronauts. We have analyzed peripheral blood lymphocytes from 11 astronauts involved in short- or long-term space flights in low-Earth orbit using high-resolution multicolor banding to assess the frequency of intrachromosomal exchanges in both pre- and post-flight samples. We did not detect any inversions in chromosome 5 from a total of 2800 cells in astronauts' blood. In addition, no complex type exchanges were found in a total of 3590 astronauts' lymphocytes analyzed by multifluor fluorescence in situ hybridisation. We conclude that, within the statistical power of this study, the analysis of interchanges for biological dosimetry in astronauts does not significantly underestimate the space radiation-induced cytogenetic damage, and complex-type exchanges or intrachanges have limited practical use for biodosimetry at very low doses.

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Chromosomal intrachanges induced by swift iron ions

Cited by 8 publications

References 28 publications

Space Radiobiology

Space Radiobiology

Radiation in Space: The Biology

Space radiation does not induce a significant increase of intrachromosomal exchanges in astronauts’ lymphocytes

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