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Coal is an organic, combustible, rock‐like natural substance that occurs in various forms from hard and brittle anthracite to soft and friable lignite. Coal mine dust often contains silica and other minerals found within the coal seam or in the adjacent strata. In the United States and other countries, coal miners are at risk of developing chronic lung diseases caused by cumulative exposure to respirable coal mine dust. These diseases can lead to significant lung function impairment, disability, and premature death. Collectively known as “black lung,” they include a spectrum of interstitial lung diseases including coal workers' pneumoconiosis (CWP), mixed dust pneumoconiosis, and dust‐related diffuse fibrosis as well as chronic airway diseases including emphysema and chronic bronchitis. Since the late 1990s, the prevalence of CWP and its most severe form, progressive massive fibrosis, have increased in the United States, most notably in central Appalachia. Factors contributing to this resurgence might include thin‐seam coal mining and/or cutting rock to access coal seams, which likely exposes miners to respirable coal mine dust with a higher content of other hazardous dusts including silica and silicates. Many countries have occupational exposure limits for coal mine dust typically based on assessment of the mass of dust collected during a work shift.
Coal is an organic, combustible, rock‐like natural substance that occurs in various forms from hard and brittle anthracite to soft and friable lignite. Coal mine dust often contains silica and other minerals found within the coal seam or in the adjacent strata. In the United States and other countries, coal miners are at risk of developing chronic lung diseases caused by cumulative exposure to respirable coal mine dust. These diseases can lead to significant lung function impairment, disability, and premature death. Collectively known as “black lung,” they include a spectrum of interstitial lung diseases including coal workers' pneumoconiosis (CWP), mixed dust pneumoconiosis, and dust‐related diffuse fibrosis as well as chronic airway diseases including emphysema and chronic bronchitis. Since the late 1990s, the prevalence of CWP and its most severe form, progressive massive fibrosis, have increased in the United States, most notably in central Appalachia. Factors contributing to this resurgence might include thin‐seam coal mining and/or cutting rock to access coal seams, which likely exposes miners to respirable coal mine dust with a higher content of other hazardous dusts including silica and silicates. Many countries have occupational exposure limits for coal mine dust typically based on assessment of the mass of dust collected during a work shift.
Background: Currently coal mining employs over 7 million miners globally. This occupational setting is associated with exposure to dust particles, heavy metals, polycyclic aromatic hydrocarbons and radioactive radon, significantly increasing the risk of lung cancer (LC). The susceptibility for LC is modified by genetic variations in xenobiotic detoxification and DNA repair capacity. The aim of this study was to investigate the association between GSTM1 (deletion), APEX1 (rs1130409), XPD (rs13181) and NBS1 (rs1805794) gene polymorphisms and LC risk in patients who worked in coal mines. Methods: The study included 639 residents of the coal region of Western Siberia (Kemerovo region, Russia): 395 underground miners and 244 healthy men who do not work in industrial enterprises. Genotyping was performed using real-time and allele-specific PCR. Results: The results show that polymorphisms of APEX1 (recessive model: ORadj = 1.87; CI 95%: 1.01–3.48) and XPD (log additive model: ORadj = 2.25; CI 95%: 1.59–3.19) genes were associated with increased LC risk. GSTM1 large deletion l was linked with decreased risk of LC formation (ORadj = 0.59, CI 95%: 0.36–0.98). The multifactor dimensionality reduction method for 3-loci model of gene–gene interactions showed that the GSTM1 (large deletion)—APEX1 (rs1130409)—XPD (rs13181) model was related with a risk of LC development. Conclusions: The results of this study highlight an association between gene polymorphism combinations and LC risks in coal mine workers.
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