Chromosomal imbalances in laryngeal and hypopharyngeal cancers detected by comparative genomic hybridization

Juhász, Attila; Balázs, Margit; Sziklay, István; Rákosy, Zsuzsa; Treszl, Andrea; Répássy, Gábor; Ádány, Róza

doi:10.1002/cyto.a.20165

Cited by 17 publications

(11 citation statements)

References 35 publications

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“…Underlying genetic abnormalities may explain this discordance between the clinical outcome and the TNM status or location. 3,4 DNA aneuploidy, such as numerical or structural chromosomal abnormalities, is found in tonsillar carcinomas. 1 Chromosomal instability (CIN) implies that cancer cells lose or gain chromosomes or chromosomal material during mitosis, 5 representing an increased rate of change in chromosomal structure that is associated with an increase in bulk DNA, such as aneuploidy.…”

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confidence: 99%

Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

et al. 2010

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confidence: 99%

Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

et al. 2010

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“…On the other hand, the remaining 8 of the 23 cases did not show a gain in this region, suggesting that this change may not always occur in ESC. Amplification at 11q13 has been reported previously not only in ESC but also in oral cancer, head and neck cancer, nasopharyngeal cancer, and several other types of cancer [21][22][23][24][25]. For example, Hui et al [21] reported this amplification as a 5.3-Mb amplicon at 11q13.1-13.3 as the most frequently detected gain in 26 nasopharyngeal cancers.…”

Section: Discussionmentioning

confidence: 81%

BAC Clones Related to Prognosis in Patients with Esophageal Squamous Carcinoma: An Array Comparative Genomic Hybridization Study

et al. 2007

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Purpose. The prognosis of patients with esophageal carcinoma is poor. To identify genomic alterations associated with poor patient prognosis, we analyzed whole DNA copy number profiles of esophageal squamous carcinomas (ESCs) using array-based comparative genomic hybridization (aCGH).Materials and Methods. Twenty-one operated and two biopsied cases of esophageal squamous cancer were examined for study. Each sample was laser microdissected to obtain pure cancer cell populations. The extracted DNA was analyzed using aCGH.Results. One of the most representative alterations was a previously reported amplification at 11q13.3. In addition, some novel alterations, such as deletion of 16p13.3, were identified. Of the 19 patients who were reassessed more than 5 years after the operation, nine were still living and 10 had died from disease recurrence. When aCGH profiles from the surviving group and the deceased group were compared, significant differences were recognized in 68 of 4,030 bacterial artificial chromosome (BAC) clones. Almost half of these clones were present at nine limiting regions in 4q, 13q, 20q, and Xq. For 22 of these 68 BAC clones, there also was a significant difference in the KaplanMeier survival curve, using the log-rank test, when comparing patients who had an alteration in a particular clone with those who did not.Conclusions. aCGH study of esophageal squamous cancer clearly identified BAC clones that are related to the prognosis of patients. These clones give us the opportunity to determine specific genes that are associated with cancer progression. The Oncologist 2007;12: 406 -417

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“…The c-MYC protein is a multifunctional transcription factor involved in the activation of DNA replication; overexpression of this protooncogene may induce chromosome aberrations and an overall dysfunction in the regulation of the cell cycle [13, 14, 20, 21]. …”

Section: Discussionmentioning

confidence: 99%

The c-MYC Protooncogene Expression in Cholesteatoma

Palkó¹,

Póliska

Csákányi

et al. 2014

BioMed Research International

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Cholesteatoma is an epidermoid cyst, which is most frequently found in the middle ear. The matrix of cholesteatoma is histologically similar to the matrix of the epidermoid cyst of the skin (atheroma); their epithelium is characterized by hyperproliferation. The c-MYC protooncogene located on chromosome 8q24 encodes a transcription factor involved in the regulation of cell proliferation and differentiation. Previous studies have found aneuploidy of chromosome 8, copy number variation of c-MYC gene, and the presence of elevated level c-MYC protein in cholesteatoma. In this study we have compared the expression of c-MYC gene in samples taken from the matrix of 26 acquired cholesteatomas (15 children and 11 adults), 15 epidermoid cysts of the skin (atheromas; head and neck region) and 5 normal skin samples (retroauricular region) using RT-qPCR, providing the first precise measurement of the expression of c-MYC gene in cholesteatoma. We have found significantly elevated c-MYC gene expression in cholesteatoma compared to atheroma and to normal skin samples. There was no significant difference, however, in c-MYC gene expression between cholesteatoma samples of children and adults. The significant difference in c-MYC gene expression level in cholesteatoma compared to that of atheroma implies a more prominent hyperproliferative phenotype which may explain the clinical behavior typical of cholesteatoma.

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Chromosomal imbalances in laryngeal and hypopharyngeal cancers detected by comparative genomic hybridization

Cited by 17 publications

References 35 publications

Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

Correlation between reduced expression of the spindle checkpoint protein BubR1 and bad prognosis in tonsillar carcinomas

BAC Clones Related to Prognosis in Patients with Esophageal Squamous Carcinoma: An Array Comparative Genomic Hybridization Study

The c-MYC Protooncogene Expression in Cholesteatoma

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