Chromosomal differences between acute nonlymphocytic leukemia in patients with prior solid tumors and prior hematologic malignancies

Mamuris, Zissis; Dumont, Jeanine; Dutrillaux, Bernard; Aurias, Alain

doi:10.1016/0165-4608(89)90006-x

Cited by 22 publications

(8 citation statements)

References 22 publications

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“…Comparison of the two distributions in a paired t test (39) revealed that they were indistinguishable (P < 0.01), demonstrating that the results obtained by both techniques are quantitatively identical. Thus, both PCR and RFLP techniques revealed a high frequency of LOH in 7q31.1-7q31.2, confirming previous reports of deletions on chromosome 7 in breast cancer (21) and in other types of cancer (14)(15)(16)(17)(18)(19)(20). Fig.…”

Section: Resultssupporting

confidence: 75%

“…These data, together with the results of our studies of microcell-mediated transfer of chromosome 7 (21) and reports of similar chromosome 7 deletions in several other neoplasias (14)(15)(16)(17)(18)(19)(20)(21), strongly suggest that there is a TSG distal to MET near 7q31.1-7q31.2, which is relevant to several human neoplasias.…”

Section: Resultsmentioning

confidence: 57%

“…Consistent deletions or inversions ofpart of a chromosome are indicative of inactivation of a nearby TSG during neoplastic progression (13). In this regard, de-letions of chromosome 7 are common throughout many different types of tumors studied, such as ovarian cancer, gastric carcinomas, and malignant myeloid disorders (14)(15)(16)(17)(18)(19)(20), indicating frequent breaks near the MET oncogene (7q31-7q33) with a frequency of27-41% in the case ofbreast cancer (21). Also, recent results using microcell-fusion transfer of human chromosome 7 to a murine-derived squamous cell carcinoma cell line indicated that the inserted chromosome can delay the onset of tumors by 2-fold to 3-fold and in some cases can even repress completely the tumorigenic potential ofthe squamous cell carcinoma cell line.…”

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confidence: 99%

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(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

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Bièche

Lidereau

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

112

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Loss of heterozygosity in human chromosome 7q was studied to determine the location of a putative tumor suppressor gene. Twenty-six of 31 cases studied presented loss of heterozygosity at one or more loci on chromosome 7q. Eighty-three percent loss of heterozygosity (in 11 informative cases) was detected by using the (C-A)3 microsatelite repeat marker D7S522 at 7q31.1-7q31.2. These results suggest that a tumor suppressor gene relevant to the development of breast cancer is present in the 7q31.1-7q31.2 region, confirming our previous evidence for a tumor suppressor gene in this chromosome and frequent deletions of the long arm in human primary breast cancers.

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Section: Resultssupporting

confidence: 75%

Section: Resultsmentioning

confidence: 57%

mentioning

confidence: 99%

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(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

Zenklusen

Bièche

Lidereau

et al. 1994

Proc. Natl. Acad. Sci. U.S.A.

112

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“…Some of them were suspected 'to arise through end-to-end joining of the 3q+ chromosome that is found as a result of the specific translocation involving chromosomes 3 and 12'. More recent examinations using various techniques of molecular cytogenetics could show that the overwhelming majority of the observed rings was constituted by chromosome 12 or parts of it (at least 85 cases reported so far: Mandahl et al, 1988aMandahl et al, , b, 1989Rydholm et al, 1990;Szymanska et al, 1995 r(20) Tiainen et al, 1988, Mandahl et al, 1988a, b, 1989 , Varsa et al, 1989 r(22) Mandahl et al, 1988aMandahl et al, , b, 1989 invariably contain amplified sequences from 12q, with a few exceptions including the MDM2 gene (Nilsson et al, 2004). A more detailed FISH analysis using the ML12q1315 probe confirmed extensive painting of the ring chromosomes found in ten adipose tissue tumors, but painting was discontinuous, i.e., the ring chromosomes were never completely painted (Dal Cin et al, 1993a).…”

Section: Ring Chromosomes In Mesenchymal Tumorsmentioning

confidence: 99%

Ring chromosomes in human neoplasias

Gebhart

2008

Cytogenet Genome Res

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Though reported from a wide variety of human neoplasias, ring chromosomes, in general, are a rare finding in these diseases. The majority were detected by chance when tumors were screened for chromosomal aberrations. In most cases they are a part of highly complex karyotypic alterations and therefore part of unfavourable prognostic factors. However, in some tumor entities (e.g. tumors of mesenchymal origin) they are of such high prevalence (up to 70% of these tumors) and of such extraordinary specificity that they can even serve as cytogenetic hallmarks for differential diagnosis and for prognostic purposes. The well-known technical problems in malignant cells of achieving high banding quality to define all single chromosomal alterations have severely hampered clear identification of the chromosomes involved in rings until recently. Substantial progress of ring identification could only be achieved when molecular cytogenetic techniques became available. By these techniques it could not only be shown that certain breakpoint regions nonrandomly contribute to ring rearrangements which – at least in certain malignancies – are of basic importance, but also the molecular consequences of these changes could be defined in some cases. The present review summarizes a great number of reports on a total of 760 ring chromosomes in human neoplasias at different sites, but includes only cases with clearly identified rings. In addition, the molecular consequences of ring formation are addressed wherever pertinent information has recently been presented in the literature.

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“…[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] The search in LILACS identified 582 articles and none of them were eligible.…”

Section: Case Reportmentioning

confidence: 99%

Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report

et al. 2017

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CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSION: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.

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Chromosomal differences between acute nonlymphocytic leukemia in patients with prior solid tumors and prior hematologic malignancies

Cited by 22 publications

References 22 publications

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

Ring chromosomes in human neoplasias

Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report

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