Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer

vandenBergdeRuiter, E; Dejong, B; Mulder, Nh; Temeerman, Gj; Koops, H. Schraffordt; Sleijfer, Dt

doi:10.1007/bf00208940

Cited by 16 publications

(3 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present obser vations confirmed our previous ones in 12 patients [ 10] and those published simultaneously with ours by de LozierBlanchet [1] and by Van den Berg-de Ruiter et al [17] in 1990. In this study we were not able to distinguish in dividual types of aberrations or special cell clones.…”

Section: Discussionsupporting

confidence: 83%

Persistence of Chromosomal Aberrations in Blood Lymphocytes of Testicular Cancer Patients

et al. 1992

View full text Add to dashboard Cite

Chromosome aberrations were studied in peripheral blood lymphocytes from untreated testicular cancer patients and others treated with chemo- and/or radiotherapy. A distinct increase in spontaneous aberrations over the level of healthy controls was found in patients treated with surgery alone. Our data suggest the existence of a certain degree of chromosome instability which may be a factor in the development of malignancy for testicular tumours, too. The frequency of aberrant cells was much higher in treated groups than in controls, and the total of aberrations was therapy related. The frequency of aberrant cells was the highest in the first 2 years after the end of treatments similarly to the results of 3 serially examined individuals. The decrease in aberrant cells was time-dependently gradual only in X-ray-treated patients. Real conclusions about the nature of therapy-related persistence of aberrant cells can be drawn from the study of a sufficient number of testicular cancer patients studied more than 1 year after the end of treatments.

show abstract

Section: Discussionsupporting

confidence: 83%

Persistence of Chromosomal Aberrations in Blood Lymphocytes of Testicular Cancer Patients

et al. 1992

View full text Add to dashboard Cite

show abstract

“…12) Chromosome analysis has shown a high incidence of numerical and structural abnormalities in cancer patient tumor tissue samples and peripheral blood lymphocytes. 13,14) In this study we investigated whether micronucleated lymphocytes or micronucleated buccal mucosa cells can be sensitive markers for the presence of head-and-neck cancer, and for the mutagenic effect of radiation in head-and-neck cancer patients during and after treatment.…”

Section: Introductionmentioning

confidence: 99%

Cytogenetic Damage in Circulating Lymphocytes and Buccal Mucosa Cells of Head-and-neck Cancer Patients Undergoing Radiotherapy

Minicucci

Kowalski²,

Maia

et al. 2005

JRR

View full text Add to dashboard Cite

This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for gender, age, and smoking habits. Results showed no statistically significant difference between patients and controls prior to radiotherapy in cytokinesis-blocked lymphocytes or buccal mucosa cells. During treatment, increased MNC frequencies were observed in both cell types. Micronucleated lymphocyte levels remained high in samples collected 30 to 140 days after the end of treatment, while MNC frequency in buccal mucosa decreased to values statistically similar to baseline values. There is controversy over the effects of age, smoking habit, tumor stage, and/or metastasis on MNC frequency. However, increased frequency of micronucleated buccal mucosa cells was seen in patients under 60 years old and in those with tumors >4 cm. In conclusion, the data show that radiotherapy has a potent clastogenic effect in circulating lymphocytes and buccal mucosa cells of head-and-neck cancer patients, and that the baseline MNC frequency in these two tissues is not a sensitive marker for head-and neck neoplasm.

show abstract

“…T h e hypothesis that genes may predispose to testicular cancer has not yet been verified. However, indications are found in familial aggregation and increased constitutional chromosomal instability (Gundy et al, 1990;van den Berg-de Ruiter et al, 1990). Structural abnormalities in the tumours have been found, of which i(12p) is the most common (Atkin and Baker, 1983;Castedo et al, 1989a, b).…”

Section: Introductionmentioning

confidence: 99%

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

Lothe

Hastie

Heimdal

et al. 1993

Genes Chromosomes & Cancer

View full text Add to dashboard Cite

Deletions within the short arm of the human chromosome 11 have been found to be involved in the genesis of several tumours, including different urogenital neoplasms. We have studied 31 male germ cell tumours (19 seminomas and 12 nonseminomas), and observed loss of heterozygosity at 11p loci in 40% (12/30) of these tumours [35% (9/26) at 11p13 and 31% (8/26) at 11p15]. Our data suggest that inactivation of one or more tumour suppressor genes on 11p are involved in the genesis of testicular cancer. In addition, identification of the parental origin of the allelic losses revealed a paternal loss in six patients and a maternal loss in one case.

show abstract

Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer

Cited by 16 publications

References 21 publications

Persistence of Chromosomal Aberrations in Blood Lymphocytes of Testicular Cancer Patients

Persistence of Chromosomal Aberrations in Blood Lymphocytes of Testicular Cancer Patients

Cytogenetic Damage in Circulating Lymphocytes and Buccal Mucosa Cells of Head-and-neck Cancer Patients Undergoing Radiotherapy

Frequent loss of 11p13 and 11p15 loci in male germ cell tumours

Contact Info

Product

Resources

About