Chromosomal Constitution in Relation With Chromosomal Length in Blastocysts of Young Women

Abstract

two-tailed t-test. RESULTS: Between December 2010 and November 2020, a total of 1475 TE embryo biopsies were tested, with results reported on 1428 samples (96.8%). The overall aneuploid rate was 42.7% and the mutation positive rate was 50.9%. The aneuploid rate for age-matched controls was 44.6% (Table 1). When divided by CGG repeat length, the aneuploid rate for full FMR1 mutation cases was greater than that of the age matched controls, but this finding was not statistically significant.CONCLUSIONS: Overall, we did not observe an increase in aneuploid rates among all FMR1 mutation carriers compared to age-matched controls. Results indicate a trend toward higher aneuploidy rates with increasing repeat length, however further studies are needed to corroborate these findings. This information could be useful in counseling FMRI carriers regarding IVF and PGT outcomes.IMPACT STATEMENT: We do not see a decreased rate of euploid results in TE biopsy samples from FMR1 expansion carriers, therefore maternal agerelated risks for aneuploidy are appropriate to use for counseling this population.References: 1.