1988
DOI: 10.1007/bf00117770
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Chromosomal changes in cell lines from mouse tumors induced by nickel sulfide and methylcholanthrene

Abstract: Rhabdomyosarcomas were induced in mice by intramuscular injections of crystalline nickel sulfide and 3-methylcholanthrene. At early passage, karyotypes were performed by G-banding for four nickel sulfide cell lines and for three 3-methylcholanthrene cell lines. Six cell lines were near-diploid and one nickel sulfide line was near-tetraploid. Three of the nickel sulfide cell lines were characterized by a rearranged marker chromosome which was present in a majority of the cells of each line. The rearrangements l… Show more

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Cited by 5 publications
(2 citation statements)
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References 41 publications
(41 reference statements)
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“…Our data suggest that nickel acetate, and perhaps other carcinogenic nickel compounds, can cause DNA repair problems and that this activity may be one of the mechanisms responsible for their carcinogenic properties. Our suggestion is also consistent with the observation of chromosome abnormalities in mouse tumors induced by nickel compounds which are not clastogenic (39).…”
Section: Discussionsupporting
confidence: 92%
“…Our data suggest that nickel acetate, and perhaps other carcinogenic nickel compounds, can cause DNA repair problems and that this activity may be one of the mechanisms responsible for their carcinogenic properties. Our suggestion is also consistent with the observation of chromosome abnormalities in mouse tumors induced by nickel compounds which are not clastogenic (39).…”
Section: Discussionsupporting
confidence: 92%
“…The clastogenic effect of nickel can be observed both in vivo and in vitro and in some cases it can be traced even after tumor formation. Thus, in one study, intramuscular injections of crystalline nickel sulfi de resulted in the appearance of rhabdomyosarcomas in mice [34]. Three cell lines established from these tumors were characterized by a rearranged marker chromosome that was present in a majority of the cells of each line.…”
Section: Genetic and Epigenetic Changes In Nickel-exposed Cellsmentioning
confidence: 99%