Chromosomal assignment of the human deoxyribonuclease I gene, DNASE1 (DNL1), to band 16p13.3 using the polymerase chain reaction

Yasuda, Toshihiro; Nadano, Daita; Iida, Reiko; Takeshita, Hitoshi; Lane, Sharon; Callen, David F.; Kishi, Kunikazu

doi:10.1159/000134038

Cited by 42 publications

(17 citation statements)

References 4 publications

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“…However, any relationship between this enzyme and DNase II remains to be elucidated. The gene for DNase I (DNASE1) has been assigned to 16p13.3 (45). Considering the lack of homology between their aa sequences, the differences in the tissue distribution of their gene expression, and their different chromosomal localizations, it seems plausible that two distinct type of DNase, DNases I and II, are present in mammals and that these may not have evolved from the same ancestral gene.…”

Section: Resultsmentioning

confidence: 99%

Molecular Cloning of the cDNA Encoding Human Deoxyribonuclease II

Yasuda¹,

Takeshita²,

Iida³

et al. 1998

Journal of Biological Chemistry

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Section: Resultsmentioning

confidence: 99%

Molecular Cloning of the cDNA Encoding Human Deoxyribonuclease II

Yasuda¹,

Takeshita²,

Iida³

et al. 1998

Journal of Biological Chemistry

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“…Our recent studies [6][7][8][9] have elucidated the complete molecular basis for the genetic poly morphism of DNase 1. and on the basis of this, a new DNase I-genotyping system using the polymerase chain reaction (PCR) has been developed [10].…”

mentioning

confidence: 99%

Population Studies of Human Deoxyribonuclease I Polymorphism

et al. 1997

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We have improved the resolution of the conventional method for phenotyping deoxyribonuclease I (DNase I), which makes use of isoelectric focusing, by the addition of amphoteric separators. The distribution of DNase I phenotypes was extensively examined using this improved method in 1,212 unrelated individuals from a Japanese population. In order to investigate a possible difference in phenotype distribution between different populations, DNA samples from Germans and African Americans were genotyped using the polymerase chain reaction. The DNASE 1*2 allele in the German population was found to be predominant among the four alleles of DNase I, in contrast to the Japanese population. These results are the first to demonstrate a wide distribution of DNase I polymorphism in the Japanese population as well as in two other populations.

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“…Two of these are identical to, and two are similar to, genes described by others (Table 1). cDNA clones identical to genes that have been described previously are NC4-5 (ZNF174, Williams et al 1995) and CR20-8 (DNASE1, Yasuda et al 1995), both of which have been mapped to chromosome 16p13.3 already. Transcripts similar but not identical to previously described genes include NC15-25 and CR6-24.…”

Section: Cdna Selectionmentioning

confidence: 58%

Construction of an ∼700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3

Centola

Chen²,

Sood

et al. 1998

Genome Res.

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We used a combination of cDNA selection, exon amplification, and computational prediction from genomic sequence to isolate transcribed sequences from genomic DNA surrounding the familial Mediterranean fever (FMF) locus. Eighty-seven kb of genomic DNA around D16S3370, a marker showing a high degree of linkage disequilibrium with FMF, was sequenced to completion, and the sequence annotated. A transcript map reflecting the minimal number of genes encoded within the ∼700 kb of genomic DNA surrounding the FMF locus was assembled. This map consists of 27 genes with discreet messages detectable on Northerns, in addition to three olfactory-receptor genes, a cluster of 18 tRNA genes, and two putative transcriptional units that have typical intron-exon splice junctions yet do not detect messages on Northerns. Four of the transcripts are identical to genes described previously, seven have been independently identified by the French FMF Consortium, and the others are novel. Six related zinc-finger genes, a cluster of tRNAs, and three olfactory receptors account for the majority of transcribed sequences isolated from a 315-kb FMF central region (between D16S468/D16S3070 and cosmid 377A12). Interspersed among them are several genes that may be important in inflammation. This transcript map not only has permitted the identification of the FMF gene (MEFV), but also has provided us an opportunity to probe the structural and functional features of this region of chromosome 16.Saturating the human genome with mapped genes so that the structure and function of each can be determined is an ultimate goal of the human genome project (Collins and Galas 1993). In addition

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Chromosomal assignment of the human deoxyribonuclease I gene, DNASE1 (DNL1), to band 16p13.3 using the polymerase chain reaction

Cited by 42 publications

References 4 publications

Molecular Cloning of the cDNA Encoding Human Deoxyribonuclease II

Molecular Cloning of the cDNA Encoding Human Deoxyribonuclease II

Population Studies of Human Deoxyribonuclease I Polymorphism

Construction of an ∼700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3

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