Chromosomal assignment of the genetic factor, tu-91k, responsible for a melanotic tumour in the Drosophila melanogaster adult female

Kosuda, Kazuhiko

doi:10.1186/1297-9686-24-6-561

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The amorphous shape of the mass also supports this interpretation, because the shape of the SDP resembles a column or cylinder, like a plug (Hopkins et al, 2020). Interestingly, Kosuda (1992Kosuda ( , 1996 reported a spermathecaspecific melanotic tumor that was visible as an "irregular shaped dense black mass" which could surround the whole of the capsule of the spermatheca when it developed. Coincidences in coloration, location and appearance let us speculate that the mass in en NK14 would also be associated with a tumor.…”

Section: Discussionmentioning

confidence: 70%

A new allele of engrailed, enNK14, causes supernumerary spermathecae in Drosophila melanogaster

et al. 2021

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A spontaneous mutation, en NK14 , was a new allele of engrailed (en) in Drosophila melanogaster. Females of en NK14 have three spermathecae, instead of two in wild type, under a wide range of developmental temperatures, while the males show no abnormal phenotype. Spermathecae of the mutant female can accept inseminated sperms, albeit with a delay of at least an hour until full acceptance compared with wild type. The time course of decrease in the number of stored sperms was thoroughly similar between the mutant and wild type. en NK14 females produced fewer progeny than wild type females despite storing a larger number of sperms. The delay of sperm entry and lower fecundity suggested some functional defects in secretory products of the spermathecae. In addition, some spermathecae in the mutant were accompanied by a mass of brown pigments in the adipose tissue surrounding the capsule. Six contiguous amino acids, Ser340-Ala345, were replaced by one Thr in en NK14 . In another mutant, en spt , Ser325 was also shown to be substituted by a Cys. These amino acid changes were located within a serine-rich region, in which Ser325, Ser340 and Thr341 were suggested as targets of Protein Kinase C by an in silico analysis. The splicing pattern of en mRNA did not differ between en NK14 and wild type in embryo, larva, pupa or adult. Our results suggest that en plays an important role in determining the number of spermathecae as well as in sperm storage function in the Drosophila female.

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Section: Discussionmentioning

confidence: 70%

A new allele of engrailed, enNK14, causes supernumerary spermathecae in Drosophila melanogaster

et al. 2021

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Deleterious Effect of the Melanotic Tumour on the Survival Rate of Drosophila melanogaster Female Flies

Kosuda

1996

Zoological Science

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The effect of melanotic tumour formation on the survival rate of female flies was investigated for a period of five weeks after eclosion in the C-104 mutant strain of Drosophila melanogaster, found in a natural population in Budapest. Melanotic tumours developed only in female flies in the vicinity of spermathecae. The incidence of tumour formation was higher in the dead females than in the living ones. This fact explicitly indicated that tumour formation has a deleterious effect on the survival rate and thus the life span of its carriers. It also implied that non-self recognition or self-defense reaction is accomplished at the expense of the organisms. The reason for the maintenance of this melanotic tumour gene in a natural population is discussed.

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Chromosomal assignment of the genetic factor, tu-91k, responsible for a melanotic tumour in the Drosophila melanogaster adult female

Cited by 2 publications

References 6 publications

A new allele of <i>engrailed</i>, <i>en<sup>NK14</sup></i>, causes supernumerary spermathecae in <i>Drosophila melanogaster</i>

A new allele of <i>engrailed</i>, <i>en<sup>NK14</sup></i>, causes supernumerary spermathecae in <i>Drosophila melanogaster</i>

Deleterious Effect of the Melanotic Tumour on the Survival Rate of Drosophila melanogaster Female Flies

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