Chromosomal analysis of bladder cancer. II. A practical method

Smeets, Wim; Pauwels, R.P.E.; Laarakkers, Lisette; Debruyne, F.M.J.; Geraedts, J. P. M.

doi:10.1016/0165-4608(87)90027-6

Cited by 10 publications

(3 citation statements)

References 12 publications

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“…Structural or numerical abnormalities of chromosome 7 have now been observed in five cases of PTC from four groups (4, 5, 1 1; current report), and in four cases they represented the sole clonal abnormality. Alterations ofchromosome 7 other tumor types such as melanoma (60,61), bladder carcinoma (62,63), and mesothelioma (64) noma, which implies a more advanced tumor with a less favorable prognosis (45). Abnormalities of chromosome 10 in the region ofq 1 -q26 have now been described in 11 PTC (3-6, 1 1; Pierotti, M. A., et al, submitted for publication; and current report) and in 9 of these cases structural 1 Oq abnormalities were the sole clonal 4 In summary, the results of this genetic study of thyroid carcinomas support the hypothesis that FTC and PTC have different genetic mechanisms underlying their pathogenesis.…”

Section: Methodsmentioning

confidence: 99%

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

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Section: Methodsmentioning

confidence: 99%

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Herrmann¹,

Hay²,

Bartelt³

et al. 1991

J. Clin. Invest.

133

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“…A direct method was used for microscopic analysis of chromosomes, as described elsewhere in detail [24]. Tumour samples were collected in 0.5% sodium citrate with 0.5 µg/ml colcemid.…”

Section: Chromosome Classificationmentioning

confidence: 99%

“…Microscopic cytogenetic analysis of metaphase chromosomes with or without banding techniques permits assessment of the number of chromosomes and the presence of structural abnormalities of chromosomes [17,24]. Studies on the prognostic value of this technique in bladder carcinoma are sparse [22].…”

Section: Introductionmentioning

confidence: 99%

Abnormalities detected in metaphase chromosomes in bladder carcinoma: prognostic value and comparison with histopathological factors

Oosterhuis¹,

Smeets²,

Janssen‐Heijnen

et al. 2002

Virchows Arch

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The objective of this study was to detect the incidence and prognostic value of chromosomal aberrations in metaphase chromosomes (hypodiploidy, hyperdiploidy and/or structural abnormalities) in Ta and T1 transitional cell carcinoma (TCC) of the bladder. Of 266 patients, the metaphase chromosomes of the primary tumour were studied using a direct microscopic analysis and classified into two categories: normal and abnormal. Recurrence and progression were prospectively recorded during a median follow-up period of 40 months and in a retrospective analysis compared with other prognostic factors. Chromosomal abnormalities were found in 48% of Ta tumours and in 92% of T1 tumours. In univariate analysis, chromosomal abnormalities were associated with recurrence-free survival ( P=0.03) and progression-free survival ( P=0.01). In multivariate analysis, chromosomal abnormalities (RR=1.98) and age (RR=0.64) were independent predictors of recurrence-free survival but not progression-free survival.

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Prognostic significance of type IV collagen and laminin immunoreactivity in urothelial carcinomas of the bladder

Schapers

Pauwels²,

Havenith³

et al. 1990

Cancer

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Invasion of a carcinoma involves the degradation and penetration of the subepithelial basement membrane (BM). This phenomenon might be used for histopathologic evaluation of neoplasms of the bladder. The authors studied the clinicopathologic data and tissue specimens of 125 cases of urothelial carcinomas collected prospectively. Penetration of the BM was evaluated by immunohistochemical staining of the BM components laminin and type IV collagen. The use of this parameter as a prognostic indicator in bladder cancer was assessed. The 5-year survival rate of patients having tumors with an interrupted or absent BM was significantly lower than that of patients having tumors with an intact BM. The rate of progression was greater in tumors with an interrupted or absent BM than in tumors with an intact BM. No association was found between BM status and recurrence. However, a significant correlation between tumor stage and BM staining was found. A correlation was also found between ploidy and BM staining as well as between histologic grade and BM staining pattern. When evaluating histologic grade, stage, ploidy, age, and BM score as prognostic parameters, the stage of bladder carcinomas turned out to be the most important factor in predicting the survival rate and the progression-free survival. However, BM staining was found to be of value for early identification of microinvasion and is helpful for correct staging of urothelial carcinomas.

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Chromosomal analysis of bladder cancer. II. A practical method

Cited by 10 publications

References 12 publications

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

Abnormalities detected in metaphase chromosomes in bladder carcinoma: prognostic value and comparison with histopathological factors

Prognostic significance of type IV collagen and laminin immunoreactivity in urothelial carcinomas of the bladder

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