Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

Salaverría, Itziar; Zettl, Andreas; Beà, Sı́lvia; Hartmann, Elena; Davé, Sandeep S.; Wright, George W.; Boerma, Evert Jan; Kluin, Philip M.; Ott, German; Chan, Wing C.; Weisenburger, Dennis D.; López‐Guillermo, Armando; Gascoyne, Randy D.; Delabie, Jan; Rimsza, Lisa M.; Braziel, Rita M.; Jaffe, Elaine S.; Staudt, Louis M.; Müller‐Hermelink, Hans Konrad; Campo, Elı́as; Rosenwald, Andreas

doi:10.3324/haematol.13071

Cited by 82 publications

(59 citation statements)

References 18 publications

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“…Interestingly, lack of differences in genomic complexity between pediatric and adult cases was independently found by the MMML 39 and LLMPP. 31 We demonstrated that these core BL cases are obviously different from other B-NHL cases with a MYC translocation, as the latter harbor more and also other genetic aberrations than 'true' BL. In 'true' BL gains of 1q, 7 and 12 are found as common recurring events, while (the even less frequent) losses mostly involve 6q, 17p as well as 13q32-q34.…”

Section: Discussionmentioning

confidence: 99%

“…25 A recent study of the LLMPP using CGH on BL revealed that the 'discrepant cases' (that is, molecular BL, but with aberrant morphology and/or immunophenotype) showed a more complex genetic make-up, including BCL2 breakpoints as detected by FISH. 31 These observations indicate that other genomic features than the MYC translocation status are important to distinguish 'true' BL from mimickers. The aim of this review is to define the cytogenetic profile of 'true' BL and to use this profile to distinguish BL from other B-cell lymphomas with an 8q24/MYC breakpoint.…”

Section: Role Of Genetics In the Diagnosis Of Blmentioning

confidence: 89%

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Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

et al. 2008

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Section: Discussionmentioning

confidence: 99%

Section: Role Of Genetics In the Diagnosis Of Blmentioning

confidence: 89%

Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

et al. 2008

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“…Although pediatric and adult Burkitt lymphoma cases have some differences in morphology and immunophenotype, 3,4 from a genomic complexity and gene expression point of view, Burkitt lymphoma in children and adults is the same disease. 13,14,23,30,31 It should also be noted that our study focused on MYC-IG rearrangement. Future studies should include non-IG partner genes to comprehensively assess the spectrum of MYC-rearranged lymphomas.…”

Section: Discussionmentioning

confidence: 99%

Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

et al. 2010

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Rearrangement of MYC with immunoglobulin genes is a hallmark of Burkitt lymphoma. However, this rearrangement is not entirely specific and is often accompanied by varying numbers of additional cytogenetic abnormalities. This study aimed to assess the impact of karyotypic complexity, in correlation with comprehensive immunophenotypic analyses on the diagnosis and clinical outcomes of 34 cases of MYC-IG rearranged lymphomas that included Burkitt lymphoma (twenty-two cases), diffuse large B-cell lymphoma (three cases), unclassifiable B-cell lymphoma with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma (six cases), and plasmablastic lymphoma (three cases). Additional cytogenetic abnormalities were observed in 26 of 34 cases (76%), including four cases (12%) that harbored dual translocations involving BCL-2 or BCl-6. Burkitt lymphoma cases had a significantly lower number of additional abnormalities (mean of 1.7), compared with unclassified B-cell lymphoma (3.3), diffuse large B-cell lymphoma (21.7), and plasmablastic lymphoma (6.7). Cases with simple karyotype (p2 additional abnormalities) were more likely to have a diagnosis of Burkitt lymphoma (89 versus 33% in patients with 42 additional abnormalities, Po0.01) and express bcl-6 (95 versus 47%, Po0.01). In addition, Burkitt lymphoma, bcl-6 expression, and simple karyotype were individual predictors of better overall survival. However, in multivariate analyses, only bcl-6 expression remained an independent predictor, although survival could be further stratified by karyotypic complexity in bcl-6( þ ) patients. We conclude that simple karyotype and bcl-6 expression suggest a diagnosis of Burkitt lymphoma and may portend better overall survival. These results may be very useful in the diagnosis and stratification of MYC-IG rearranged high-grade B-cell lymphomas.

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“…The clinical behavior was aggressive. 104 Similarly, a second GEP study of BL found a subset of tumors with an intermediate expression profile between BL and DLBCL. These For personal use only.…”

Section: Gray Zones Between Burkitt and Diffuse Large B-cell Lymphomamentioning

confidence: 95%

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

Campo

Swerdlow

Harris

et al. 2011

Blood

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The World Health Organization classification of lymphoid neoplasms updated in 2008 represents a worldwide consensus on the diagnosis of these tumors and is based on the recognition of distinct diseases, using a multidisciplinary approach. The updated classification refined the definitions of well-recognized diseases, identified new entities and variants, and incorporated emerging concepts in the understanding of lymphoid neoplasms. However, some questions were unresolved, such as the extent to which specific genetic or molecular alterations define certain tumors, and the status of provisional entities, categories for which the World Health Organization working groups felt there was insufficient evidence to recognize as distinct diseases at this time. In addition, since its publication, new findings and ideas have been generated. This review summarizes the scientific rationale for the classification, emphasizing changes that have had an effect on practice guidelines. The authors address the criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly. The issue of borderline categories having overlapping features with large B-cell lymphomas, as well as several provisional entities, is reviewed. These new observations chart a course for future research in the field. (Blood. 2011

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Chromosomal alterations detected by comparative genomic hybridization in subgroups of gene expression-defined Burkitt's lymphoma

Cited by 82 publications

References 18 publications

Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

Translocations involving 8q24 in Burkitt lymphoma and other malignant lymphomas: a historical review of cytogenetics in the light of todays knowledge

Simple karyotype and bcl-6 expression predict a diagnosis of Burkitt lymphoma and better survival in IG-MYC rearranged high-grade B-cell lymphomas

The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications

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