Chromosomal abnormalities detected by multicolor fluorescence in situ hybridization in fine-needle aspirates from patients with small lymphocytic lymphoma are useful for predicting survival

Proliferation centers in chronic lymphocytic leukemia: correlation with cytogenetic and clinicobiological features in consecutive patients analyzed on tissue microarrays

“…29,30 The TMA technology offers the possibility to analyze simultaneously a consistent number of cases thus reducing costs and experimental variability. 21,24 To the best of our knowledge, the present study represents the most extensive analysis conducted on biopsies of patients affected by CLL/SLL.…”

“…30 Excluding those cases in which failure was a consequence of lack of tissue, assessable results were obtained in 86.8 to 92.8% of the cases with each single probe (Table 1) A second methodological consideration should be raised concerning patient selection for this study. As in previous studies, 23 patients with progressive disease and clinically relevant adenopathy were included in our analysis.…”

“…3,8 Caraway et al 30 found abnormal FISH signal patterns in 81% of CLL/SLL cases on fine-needle aspirates, and Flanagan et al 29 described at least one cytogenetic aberration in all 18 patients analyzed on lymph node biopsy.…”

Lymph Node Fine-Needle Cytology: Beyond Flow Cytometry

“…1, 2). These tests provide useful information regarding clonality, or distinctive chromosomal/molecular abnormalities associated with specific entities and lymphoid cell lineages, confirming NHL diagnosis - albeit with some exceptions and limitations [5,9,10,11,12,13,14,15,16,17,18]. Classical cytogenetics include the routine analysis of G-banded chromosomes and other cytogenetic banding techniques for the study of cell structure and chromosomes.…”

New developments in the pathology of malignant lymphoma. A review of the literature published from August 2013 to December 2013

“…This study shows possibilities of FNA in an experienced setting. Also, multicolor FISH is possible on FNA material as shown by Caraway et al [102]. In 49 out of 50 patients with CLL, they were able to obtain data on genetic aberrations, with similar prognostic impact as known from traditional studies.…”