Chromosomal aberrations in peripheral blood lymphocytes from native Andean women and children from Northwestern Argentina exposed to arsenic in drinking water

Low 8-oxo-7,8-dihydro-2′-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic

“…We did not find any clinical signs of As-induced hyperkeratosis on the palms of the hands in any of the women studied, although a previous study showed an increased frequency of micronuclei and of trisomy in lymphocytes from exposed children and women compared with non-exposed controls [48]. Although it is clear that several environmental exposures result in increased levels of 8-OxodG [49], the relation between levels of urinary 8-OxodG and future risk of health effects, such as cancer, is not well characterized.…”

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

“…FISH is now a widely used tool in the analysis of chromosome changes in human cancers, including leukemias, and in prenatal diagnostics (Cohen et al, 1993;Gray and Pinkel, 1992). It has been used extensively to analyze chromosome damage induced by exposure to ionizing radiation (Gray et al, 1994;Tucker and Senft, 1994) and has also been gradually applied to populations exposed to chemicals and various carcinogens (Dulout et al, 1996;Rupa et al, 1995;Zhang et al, 1996b). FISH-based analysis of interphase cells can be used to detect numerical chromosome changes or specific rearrangements.…”

Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.

“…Mechanisms proposed to be involved in the development of arsenic-induced cancer in skin and other tissues include altered DNA methylation (10)(11)(12), DNA repair/ replication disturbances (13,14), clastogenicity and aneuploidy (15), dysregulated cell proliferation (10,16), and generation of oxidative stress (17,18). Arsenic-induced oxidative stress or redox disturbance (17,(19)(20)(21) contributes to DNA damage (22)(23)(24), chromosomal aberrations (25), and protein expression alterations (22,26).…”