Chromosomal aberrations and fetotoxic effects of atmospheric arsenic exposure in mice

Abstract

Fetal chromosomal damage and toxicity were investigated in mice exposed to the atmospheric concentrations of 28.5 mg m-3, 2.9 mg m-3 and 0.26 mg m-3 of arsenic for 4 h per day on the 9th, 10th, 11th and 12th days of gestation. On the 18th day, the fetuses were removed, and the following parameters were examined: the number of dead fetuses, retardation in growth, osteogenesis and chromosomal aberrations in liver cells. It was found that exposure to As2O3 at 28.5 mg m-3 caused fetotoxic effects and chromosomal damage, while the two lower exposures produced no significant changes with the exception of a slight decrease (9.9 and 3.1%, respectively) in fetal weight.

Arsenic-induced biochemical and genotoxic effects and distribution in tissues of Sprague–Dawley rats

“…These genotoxic effects have been observed in in-vivo experiments with mouse fetal chromosome [58] as well as with mouse fibroblasts [59]. Arsenic-induce SCAs has also been demonstrated in in in-vitro studies with CHO cells [60–62], V79 cells [63], and SHE cells [23, 64].…”

Arsenate‐induced apoptosis in murine embryonic maxillary mesenchymal cells via mitochondrial‐mediated oxidative injury

“…Drinking water contaminated with arsenic has created a serious health hazard in many regions of the world (Chen et al, 2005). Arsenic ingestion through drinking contaminated water during pregnancy has been reported to increase the incidence of abortion (Aschengrau et al, 1989), and maternal arsenic exposure resulted in chromosomal aberrations in fetal cells (Nagymajtenyi et al, 1985).…”

A review on exposure and effects of arsenic in passerine birds

“…Increased incidences of Raynaud's phenomenon (peripheral vascular disease), vasospasticity, increased systolic blood pressure Humans Jensen and Hansen (1998); Lagerkvist et al (1986) Dermal effects Dermatitis, mild pigmentation, keratosis of skin, or gross pigmentation with hyperkeratinization of exposed skin Humans Cöl et al (1999); Perry et al (1948) Neurological effects Increased in peripheral neuropathy, decreased nerve conduction velocity Humans Feldman et al (1979); Lagerkvist and Zetterlund (1994) Developmental effects Increased incidence of abortion and congenital malformations in children Humans Nordström et al, (1979aNordström et al, ( , 1979b Ocular effects Chemical conjunctivitis Humans Pinto and Mcgill (1953) Cancer Lung cancer Humans Enterline et al, (1987aEnterline et al, ( , 1987b Holson et al (1999); Nagymajtényi et al (1985) Immunological effects Decreased pulmonary bactericidal activity and increased susceptibility to streptococcal infections Mouse Aranyi et al (1985) Gastrointestinal effects Gross gastrointestinal lesions Rat Holson et al (1999) Inhalation exposure (organic arsenic) Respiratory effects Respiratory distress and bright red lungs with dark spots Rat and mouse Stevens et al (1979) Dermal effects Erythematous lesions on feet and ears (probably due to direct irritation from dermal contact with the dust) Rat Stevens et al (1979) Ocular effects Encrustation around the eyes (probably due to direct irritation from ocular contact with the dust)…”