Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: A case report

M, Kefeli; Yıldız, Levent; Aydın, Oğuz; Kandemır, Bedrı; Yılmaz, Ali Faik

doi:10.1016/j.prp.2007.06.003

Cited by 21 publications

(33 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Between 1993 and 2009, 8 case reports documented 9 RCCs with intratumoral fat, 8 of which were confirmed by pathologic examination. [3][4][5][6][7][8][9][10][11] Of these reported RCCs, 5 had documented fat in association with calcification or ossification 6,7,11 or bone marrow elements. 3,9 However, 4 cases of RCC had fat without calcification.…”

Section: Discussionmentioning

confidence: 99%

“…2 The presence of fat within renal neoplasms has been reported mainly in the radiology literature in the context of radiologic differential diagnosis of angiomyolipomas (AMLs). [3][4][5][6][7][8][9][10][11] The histopathologic features of RCC with intratumoral fat, however, have not been reported in the literature. RCC with intratumoral fat is important to recognize because it may be mistaken for tumor invasion into perinephric or renal sinus fat, which will lead to erroneous staging of RCC cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Aron

Aydın

Sercia

et al. 2010

American Journal of Clinical Pathology

View full text Add to dashboard Cite

Intratumoral fat and angiomyolipomas (AMLs) occurring within renal cell carcinomas (RCCs) have rarely been reported but may be mistaken for tumor invasion into perinephric or renal sinus fat or misdiagnosed as tumor exhibiting sarcomatoid differentiation. We report 16 such cases. In 14 RCC cases, there was intratumoral fat, 9 of which had fat located peripherally near the capsule (n = 6), renal sinus (n = 1), or both (n = 2). Inflammatory infiltrates and osseous metaplasia were identified in the intratumoral fat in 7 and 8 cases, respectively. Two cases had intratumoral AML foci located at the periphery of RCC. Intratumoral fat or AML at the periphery of RCC simulated the invasion into the fat, while the smooth muscle component of AML resembled spindle cell, or sarcomatoid, differentiation. Our study highlights the potential pitfalls in staging and diagnosis when intratumoral fat or AML is found within RCC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Aron

Aydın

Sercia

et al. 2010

American Journal of Clinical Pathology

View full text Add to dashboard Cite

show abstract

“…Osseous metaplasia has also been reported in patients with renal diseases, including less than 20 cases of the major subtypes of RCC [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][23][24][25][26]. Table 1 summarizes clinicopathologic features of these cases, including the present case, reported in case studies of osseous metaplasia associated with RCC.…”

Section: Discussionmentioning

confidence: 91%

“…Sarcomatoid differentiation is also seen in a subset of RCCs and is generally associated with poor patient outcomes. By contrast, metaplastic bone formation with or without bone marrow elements in RCC is extremely rare yet has been reported predominantly in clear cell [2][3][4][5][6][7][8][9][10][11][12] and chromophobe [13][14][15][16] subtypes. We here present a case of papillary RCC with osseous metaplasia along with a review of the literature on this unusual condition.…”

Section: Introductionmentioning

confidence: 99%

Renal cell carcinoma with osseous metaplasia: A case report and literature review

Maioli¹,

Sharma²,

Crane³

et al. 2017

Integr Cancer Sci Therap

View full text Add to dashboard Cite

Ossification is rarely seen in renal cell carcinomas. We report a case of a 63-year-old man who was found to have bilateral renal masses on positron emission tomography-computed tomography. One of partial nephrectomy specimens histologically showed a papillary renal cell carcinoma containing bone trabeculae. We also review renal cell carcinoma cases with osseous metaplasia reported in the literature.

show abstract

“…The presence of pancalyceal subepithelial calcification secondary to acquired obstructive uropathy, to the best of our knowledge, is not described in the literature. Additionally, the presence of 'bone formation' as evidenced by presence of marrow is extremely rare in benign cases [5] , while its presence in renal cell carcinoma is possibly related to production of bone morphogenetic protein [9,10] .…”

Section: Discussionmentioning

confidence: 99%

‘Porcelain Kidney’: Case Report and Review of the Literature

2012

View full text Add to dashboard Cite

A rare case of pan-subepithelial dystrophic calcium deposition and bone marrow formation in hydronephrosis secondary to obstructive urolithiasis is reported and discussed. An elderly gentleman presented with accelerated hypertension, a nonfunctioning left kidney secondary to obstructive nephrolithiasis with additional pancalyceal calcification. His left retroperitoneoscopic nephrectomy specimen revealed sterile hydronephrosis secondary to an impacted ureteropelvic junction stone and pan-subepithelial fibrocalcific lamellar deposition. Special stains confirmed end-stage renal disease with chronic pyelonephritis with subepithelial dystrophic calcium deposition and evidence of bone marrow formation.

show abstract

Chromophobe renal cell carcinoma with osseous metaplasia containing fatty bone marrow element: A case report

Cited by 21 publications

References 16 publications

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Renal Cell Carcinomas With Intratumoral Fat and Concomitant Angiomyolipoma

Renal cell carcinoma with osseous metaplasia: A case report and literature review

‘Porcelain Kidney’: Case Report and Review of the Literature

Contact Info

Product

Resources

About