Chromophobe renal cell carcinoma-like thyroid carcinoma: A novel clinicopathologic entity possibly associated with tuberous sclerosis complex

Hirokawa, Mitsuyoshi; Miyauchi, Akira; Kihara, Minoru; Kudo, Takumi; Hashimoto, Yuko; Suzuki, Shinichi; Daa, Tsutomu; Vuong, Huy Gia; Mitsutake, Norisato

doi:10.1507/endocrj.ej17-0096

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…Recently, three cases of chromophobe renal cell carcinoma-like thyroid carcinoma have been reported in three young adults, two of whom had TSC (Hirokawa et al, 2017). Whether this type of carcinoma is a novel clinicopathological entity associated with TSC awaits further research.…”

Section: Thyroid Involvementmentioning

confidence: 99%

Less common manifestations in TSC

Boronat

Barber

2018

American J of Med Genetics Pt C

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Tuberous sclerosis complex (TSC) is due to pathogenic variants in TSC1 or TSC2 genes resulting in hyperactivation of the mTOR pathway. Many organ systems can be affected, such as brain, skin, eye, heart, bone, kidney, or lung. Typical lesions of TSC usually are those included as major criteria, including angiofibromas, hypomelanotic macules, tubers, subependymal nodules, angiomyolipomas, cardiac rhabdomyomas, and lymphangioleiomyomatosis. However, there are many other manifestations less frequent and/or less well known, many of them not included as clinical diagnostic criteria that are part of the clinical spectrum of TSC. The focus of this review will be on these less common and less well-known manifestations of TSC. Among the rare manifestations, we will discuss some clinical findings including arteriopathy, arachnoid cysts, lymphatic involvement, chordomas, gynecological, endocrine, and gastrointestinal findings. Among the manifestations that are very frequent but much less well known, we find the sclerotic bone lesions. Although they are very frequent in TSC they have been largely overlooked and not considered diagnostic criteria, mainly because they are asymptomatic. However, it is important to know their typical characteristics to avoid misdiagnosing them as metastasis.

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Section: Thyroid Involvementmentioning

confidence: 99%

Less common manifestations in TSC

Boronat

Barber

2018

American J of Med Genetics Pt C

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“…To date, there are more than 12 variants of PTC that have been described in the literature (Table 1), but not all of them are recognized by the WHO [9][10][11]. In general, the diagnostic accuracy of FNAC for PTC is around 96% in the literature [6].…”

Section: The Importance Of Recognizing Variants On Fine Needle Aspiramentioning

confidence: 99%

Variants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimens

Canberk

Montezuma²,

İnce

et al. 2019

Acta Cytologica

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Background: Thyroid cancer accounts for 1% of cancer cases in developed countries, in which papillary thyroid carcinoma (PTC) is the most common type. There are multiple variants of PTC described to date, some of them with aggressive behavior and poor clinical outcome. These variants are well described and accepted in recent guidelines of many international societies, and the prognostic and management implications are well laid out. Due to their established clinical importance and to guide appropriate surgical management, it is now imperative in clinical practice, including cytopathology, to differentiate aggressive variants from nonaggressive ones. This review aims to describe the variants of PTC and to provide a practical algorithmic approach to facilitate the cytological diagnosis of these variants. Summary: Subtyping PTC variants on fine needle aspiration cytology (FNAC) is challenging even for the most experienced cytopathologist. To facilitate a correct subtyping on FNAC, we propose a stepwise approach that is mainly designed for conventional smear methodology. This approach requires first to stratify the lesions into oncocytic and nononcocytic features before analyzing further details in cell morphology and pattern. Key Messages: (1) Subtyping in PTC is possible on cytopathology. (2) The main aim of the cytopathologist is to differentiate aggressive from nonaggressive variants. (3) The subtyping of PTC can help in the surgical management of the patients.

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Aggressive/Non-aggressive Oncocytic/Non-oncocytic Variants of Papıllary Thyroid Carcınoma

Canberk

2019

Thyroid FNA Cytology

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Chromophobe renal cell carcinoma-like thyroid carcinoma: A novel clinicopathologic entity possibly associated with tuberous sclerosis complex

Cited by 7 publications

References 21 publications

Less common manifestations in TSC

Less common manifestations in TSC

Variants of Papillary Thyroid Carcinoma: An Algorithmic Cytomorphology-Based Approach to Cytology Specimens

Aggressive/Non-aggressive Oncocytic/Non-oncocytic Variants of Papıllary Thyroid Carcınoma

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