Chromophobe Adenoma of the Pituitary Gland

Mogensen, Erik F.

doi:10.1530/acta.0.0240135

Cited by 24 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The recorded incidence of hypopituitarism in several large predominantly surgically treated series of pituitary tumours reported in recent years varies greatly, according to the definition of pituitary deficiency used (Bakay, 1950 ;Horrox et alii, 1952 ;Heimbach, 1957 ;Jefferson, 1957a;Mogenson, 1957). Nurnberger and Korey (1953), in their detailed monograph, attempted a more systematic classification of endocrine function, and Troen and Rynearson (rg56) classified their patients as showing marked, mild or no endocrine deficiency ; but both stressed the dfficulty of defining the clinical features of hypopituitarism.…”

Section: Discussionmentioning

confidence: 99%

“…Before operation, gonadal function was most commonly affected ; but the quoted incidence varied from 30% to go%, and different authors report a preponderance in males (Mogenson, 1957) and females (Bakay, 1950 ;Nurnberger and Korey, 1953), depending largely upon whether amenorrhrea alone was regarded as evidence of loss of endocrine function.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical hypothyroidism was rare, although reduction in basal metabolic rate was common (Peters et alii, 1949 ;Bakay, 1950;Nurnberger and Korey, 1953 ;Troen and Rynearson, 1956 ;Heimbach, 1957;Mogenson, 1957). Mogenson's suggestion that this reduction may not be due to hypothyroidism alone has been supported by the detailed studies of Falkheden and Skanse (rg6z), who showed that although reduction in basal metabolic rate commonly followed transsphenoidal hypophysectomy, this was not associated with clinical hypothyroidism and was not entirely corrected by the administration of thyroxine.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Pituitary Deficiency in Patients With Pituitary Tumours

Martin

1966

Australasian Annals of Medicine

View full text Add to dashboard Cite

SUMMARY In 44 cases of tumours of the pituitary gland, the incidence of pituitary deficiency was determined; eight patients were severely hypopituitary, 16 had partial pituitary deficiency, and in 20 there was no evidence of loss of endocrine function. There was an increased incidence of hypopituitarism in patients with purely chromophobe tumours and in those with an upward extension above the diaphragma sellæ of more than 1·5 cm. There was no relation between the incidence of hypopituitarism and the size of the pituitary fossa on X‐ray examination. In the 28 patients explored by transfrontal craniotomy, there was a close association between the development of both severe hypopituitarism and diabetes insipidus and damage to the median eminence of the hypothalamus or the infundibulum. Despite some difficulty in the accurate classification of pituitary function, this investigation has demonstrated the importance of the integrity of the hypothalamic‐hypophyseal neuro‐vascular connections in the maintenance of pituitary function, even in the presence of a pituitary tumour. It is hoped that this will be of value in the management of patients undergoing operations for pituitary tumours, and in rare cases may influence the type of surgical procedure employed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pituitary Deficiency in Patients With Pituitary Tumours

Martin

1966

Australasian Annals of Medicine

View full text Add to dashboard Cite

show abstract

“…The lattice parameter calculated from the position of the peaks is 5.44(4) ± 0.01 and 5.41(3) ± 0.01 for films A and B, respectively. From the known relationship between the lattice expansion and oxygen stoichiometry [15] one can deduce the mean oxygen content in films A, CeO 1.94 ± 0.02 , and of films B, CeO 2.00 ± 0.02 . The differences in stoichiometry were too small to be detected by energy-dispersive X-ray fluorescence spectroscopy (EDS) or COMMUNICATIONS a) b) Fig.…”

mentioning

confidence: 99%

Anomalous Expansion of CeO₂ Nanocrystalline Membranes

Nair

Wachtel

Lubomirsky³

et al. 2003

Advanced Materials

View full text Add to dashboard Cite

Thin nanocrystalline ceramic membranes of ion conductive materials are very promising for a number of applications ranging from oxygen sensors to fuel cells. Owing to its high ionic conductivity compared to many alternative oxygenconducting materials, [1,2] heavily doped cerium dioxide (for instance Ce 0.8 Gd 0.2 O 1.9 ) is particularly attractive for these applications. Undoped oxygen deficient CeO 2±x is a mixed ionic±electronic conductor with predominantly electronic n-type conductivity. The defect equilibrium in undoped CeO 2 has been relatively well studied [3±7] and therefore the undoped material constitutes a good model system. The slow chemical reaction between CeO 2 and Si [8,9] might also permit applications of CeO 2 -based films and membranes integrated in Sibased microelectromechanical systems (MEMS). Thin membranes are usually prepared from thin substratesupported films by local substrate removal. This substrate removal (ªmembrane releaseº) is accompanied by a change in the macroscopic and microscopic stresses that may cause the membranes to disintegrate. In addition, inhomogeneity of oxygen concentration results in a variation of the lattice parameters and ªchemically inducedº mechanical stresses.[10±13]Thus chemical [3,4] and mechanical properties of nanocrystalline CeO 2 -based electrolytes are interdependent. The present work reports on mechanical and chemical processes occurring in undoped nanocrystalline CeO 2 membranes due to the order±disorder transition of oxygen vacancies. For the present study, 1.5 ± 0.2 lm thick CeO 2 films were deposited by radio frequency (RF) magnetron plasma sputtering on Si. Two oxygen/argon sputtering gas ratios, 1:1 (henceforth referred to as films A) and 1:5 (henceforth referred to as films B), were used. Post-deposition annealing allowed the mechanical stress, lattice cell size, and the optical properties of the films to reach constant values. As-deposited films A and B were under a compressive stress of 1.5±2 GPa. Post-deposition annealing decreased the stress to ± 150 MPa for films A and to 0±200 MPa for films B. The X-ray diffraction (XRD) patterns of films A and B were consistent with the standard pattern of cubic CeO 2[14] with a preferred orientation of (111) (Figs. 1a,b). The lattice parameter calculated from the position of the peaks is 5.44(4) ± 0.01 and 5.41(3) ± 0.01 for films A and B, respectively. From the known relationship between the lattice expansion and oxygen stoichiometry [15] one can deduce the mean oxygen content in films A, CeO 1.94 ± 0.02 , and of films B, CeO 2.00 ± 0.02 . The differences in stoichiometry were too small to be detected by energy-dispersive X-ray fluorescence spectroscopy (EDS) ) WAXD patterns of the CeO 2 membranes A and B, respectively, indicating that CeO 2 remained close to the cubic phase after substrate removal. Due to the low angular resolution of the WAXD measurements calculation of small differences in lattice parameters is not possible.

show abstract

“…Mogensen (90) details the results of surgical removal of chromophobe adenoma in 60 patients. Seven patients died as a result of the operation.…”

Section: Anterior Pituitarymentioning

confidence: 99%

Endocrinology

Asper¹,

Wilson²

1958

Annu. Rev. Med.

View full text Add to dashboard Cite

Progress in endocrinology has been rapid. So large is the field that in one year's harvest an entire chapter could be devoted to each of the endo crine glands. Remarkable achievements have been in many instances be cause of the successful application of newer techniques such as chromatog raphy, radioisotope tracer procedures, and microchemical analyses. In this review an appraisal has been made of experimental work relating to the anterior pituitary, thyroid, adrenal cortex, parathyroid, and pancreas. ANTERIOR PITUITARYMuch interest has been shown in the hormones of the anterior pituitary. Variability of experimental data pertaining to these hormones has resulted, in large measure, from the use of impure preparations and, although im proved methods of purification have become available, they remain expen sive and laborious. Highly purifi ed hormones are now obtainable for re search purposes from the Endocrinology Section of the National Institutes of Health (1), and it seems likely that'their use will lead to a better appraisal of the specifi c action of these substances.For many years attempts have been made to ascribe specific hormonal functions to the various cells of the pituitary. At first there was only con jecture, but later assignation of function to specific cell types was based on histological examination of the pituitary in patients with various glandular disorders. More recently, special stains and solvents, bioassays, and selective destruction of minute parts of the pituitary have been applied to this analy sis. Many such studies have been performed and the definitive results of a recent project are outlined by Barrnett et al.(2 ). These workers show that thyrotropic, follicle-stimulating, and luteinizing hormones are localized to those basophiles which have an affinity for periodic acid-Schiff stain.Gro wth ho rmone (GH}.-It has been recognized that growth hormone from bovine or porcine sources is ineffective in man. Indeed, a degree of 'The survey of literature pertaining to this review was completed in August, 1957.For the sake of brevity the abbreviation et ai, is used when three or more authors' names appear on a paper. S The following abbreviations are used: GH (growth hormone); ACTH (adrenocorticotropin); MSH (melanocyte-stimulating hor;mone); TSH (thyroid stimulating hormone); FSH (follicle-stimulating hormone); LH (luteinizing hormone) : PBI (protein-bound iodine) : BMR (basal metabolic rate): TBP (thy roxine-binding protein) : PTH (parathyroid hormone ) : GFR (glomerular filtration rate): Tmp (maximal rate of tubular reabsorption of phosphorus by kidney): Tmo (maximal rate of tubular reabsorption of glucose by kidney).

show abstract

Chromophobe Adenoma of the Pituitary Gland

Cited by 24 publications

References 0 publications

Pituitary Deficiency in Patients With Pituitary Tumours

Pituitary Deficiency in Patients With Pituitary Tumours

Anomalous Expansion of CeO₂ Nanocrystalline Membranes

Endocrinology

Contact Info

Product

Resources

About

Chromophobe Adenoma of the Pituitary Gland

Cited by 24 publications

References 0 publications

Pituitary Deficiency in Patients With Pituitary Tumours

Pituitary Deficiency in Patients With Pituitary Tumours

Anomalous Expansion of CeO2 Nanocrystalline Membranes

Endocrinology

Contact Info

Product

Resources

About

Anomalous Expansion of CeO₂ Nanocrystalline Membranes