Chromones from the Endophytic Fungus Pestalotiopsis sp. Isolated from the Chinese Mangrove Plant Rhizophora mucronata

Abstract

Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.

Marine natural products

“…191 The alkaloids plectosphaeroic acid A-C 207-209 were isolated from Plectosphaerella cucumerina [sediments, (Barkley Sound, British Columbia)] as inhibitors of indoleamine 2,3-dioxygenase (IDO). 195 Treatment of a culture of Spicaria elegans [sediment, (Jiaozhou Bay, China)] with the cytochrome P450 inhibitor metyrapone, initiated production of two deoxy-cytochalasins, 7-deoxy-cytochalasin Z 7 216 (modestly cytotoxic) and 7-deoxy-cytochalasin Z 9 217. 193 Culture of Pestalotiopsis sp.…”

New Austalides from the Sponge‐Associated Fungus Aspergillus sp.

“…[7][8][9][10][11] Examples of isolated metabolites include meroterpenoids, [10,[12][13][14] isochroman derivatives, [9,[15][16][17] drimane sesquiterpenoids, [7,18] and cyclic tripeptides, [11] which exhibited interesting biological activities such as plant growth inhibition, [15] cytotoxic activity against tumor cell lines, [7,9] selective antifungal activity, [11] as well as inhibition of endothelin-type B receptors. [18] As part of our ongoing research on marine fungi, [7,19,20] we have investigated a marine-derived fungal Aspergillus strain, isolated from a specimen of the Mediterranean sponge Tethya aurantium. In this study, five new meroterpenoids, named austalides M-Q (1-5) (Figure 1), along with nine known compounds (6)(7)(8)(9)(10)(11)(12)(13), were isolated.…”

A New Polyunsaturated Acid from the Marine-Derived Streptomyces violans (No. HTTA-F04129)

“…Based on the above, the structure of 1 was thus establised, on the basis of the analysis of 1D and 2D NMR spectroscopic experiments, as (2E,4Z,6E,8Z)-5,9-dimethyl-10-oxododeca-2,4,6,8-tetraenoic acid. Furthermore, the known compounds 2 and 3 were identified by comparison of their spectroscopic data with those in the literature as benzodipyran and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone [6][7][8].…”