Chromone glycosides from Schumanniophyton magnificum

Tané, Pierre; Ayafor, J. Foyere; Sondengam, B.L.; Connolly, Joseph D.

doi:10.1016/0031-9422(90)80071-n

Cited by 26 publications

(18 citation statements)

References 8 publications

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“…2-methyl-5,7-dihydroxychromone 5-O-β- d -glucopyranoside (1) : white needles, mp 162–163 °C, violet color on TLC under UV-light (254 nm); 1 H NMR (MeOD) δ : 6.77 (1H, d, J = 2 Hz, H-6), 6.51 (1H, d, J = 2 Hz, H-8), 6.01 (1H, s, H-3), 4.82 (1H, d, J = 8 Hz, H-1‘), sugar protons H2′–H6′, at δ 3.98–3.32, 2.33 (3H, s, Me), 13 C NMR (MeOD) δ : 178.8 (C-4), 165.7 (C-7), 163.1 (C-8a), 159.5 (C-2), 158.6 (C-5), 110.2 (C-3), 107.7 (C-4a), 103.6 (C-6), 103.2 (C-8), 97.7 (C-1′), 77.2 (C-3′), 75.8 (C-5′), 73.3 (C-2′), 69.8 (C-4′), 61.1 (C-6′), 18.5 (Me-2). 1 H and 13 C NMR data were consistent with other literature; molecular ion peak m/z 354 [M] + corresponding to the molecular formula C 16 H 18 O 9 (Tane et al, 1990).…”

Section: Methodssupporting

confidence: 88%

Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia

Fawzy

Al‐Taweel

Perveen

et al. 2017

Saudi Pharmaceutical Journal

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is an important genus of the Euphorbiaceae family. The genus is represented by five species in Saudi Arabia. Forssk. Fl. Aeg is traditionally used as a cure for stomachache, dyspepsia, rheumatism, dermatitis, and swellings of the body. The present study endeavors to provide a phytochemical and biological evaluation of the plant, with the aim of relating activity to constituting secondary metabolites in the plant. Column chromatographic separation of the methanol extract led to the isolation of four compounds namely 2-methyl-5,7-dihydroxychromone 5--β-d-glucopyranoside acalyphin apigenin and kaempferol 3--rutinoside . The plant extracts and the isolated compounds were subjected to biological assays to screen peroxisome proliferator-activated receptor alpha (PPARα) and PPARγ agonistic, anti-inflammatory and cytotoxic activities. Results proved for the first time, the PPARγ activator effect of acalyphin, as well as its promising anti-inflammatory activity, in addition to the dual PPAR activator effect of the chromone glucoside. The plant extracts and isolated compounds were non-cytotoxic to the tested cell lines. Thus could be a valuable source of important therapeutics that may hold clinical prospect.

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Section: Methodssupporting

confidence: 88%

Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia

Fawzy

Al‐Taweel

Perveen

et al. 2017

Saudi Pharmaceutical Journal

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“…The chromane-based polyketides are found in fungi (this work and others) and plants such as Aloe arborescens (family Aloaceae),51 Dysoxylum acutangulum (Meliaceae),43 Eugenia caryophyllata (Myrtaceae),52 Crossosoma bigelovii (Crossosomataceae),53 Knoxia corymbosa (Rubiaceae),54 and Schumanniophyton magnificum (Rubiaceae) 55. Many chromane derivatives have promising biological activities 56.…”

Section: Discussionmentioning

confidence: 77%

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

et al. 2019

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“…A decoction of the bark is in great repute among some tribes of Cameroon as a remedy for dysentery and used as an enema (Tane et al, 1990), while other tribes use it as a lotion after circumcision (Irvine, 1961). The juice is used as a snake bite remedy in Nigeria and the protective effects of the extract against snake venom have been demonstrated (Akunyili and Akubue, 1986;Houghton et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

Bickii¹,

Tchouya²,

Tchouankeu³

et al. 2007

Afr. J. Trad. Compl. Alt. Med.

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Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The results showed that the extracts of these plants possessed some antimalarial activity, the methanol extract of Picralima nitida demonstrating the highest activity in vitro. Further isolation and identification of some active compounds from these plants will justify their common use in traditional medicine for the treatment of malaria or fever in Cameroon.

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Chromone glycosides from Schumanniophyton magnificum

Cited by 26 publications

References 8 publications

Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia

Bioactivity and chemical characterization of Acalypha fruticosa Forssk. growing in Saudi Arabia

Dalmanol biosyntheses require coupling of two separate polyketide gene clusters

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

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