Chromomycin A2 Induces Autophagy in Melanoma Cells

Guimarães, Larissa Alves; Jimenez, Paula Christine; Sousa, Thiciana da Silva; Freitas, Hozana P. S.; Rocha, Danilo D.; Wilke, Diego Veras; Martín, Jesús; Reyes, Fernando; Pessoa, Otília Deusdênia Loiola; Costa-Lotufo, Letı́cia V.

doi:10.3390/md12125839

Cited by 22 publications

(28 citation statements)

References 43 publications

(52 reference statements)

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“…is Cromomycin A2. This aureolic acid promoted autophagy in the metastatic melanoma cell line MALME-3M and presented an IC 50 of 16.7 nM [21]. Other potent cytotoxics derived from bacteria are Anthracyclinones 1 and 4 extracted from Micromonospora sp.…”

Section: Bacteria Actinobacteria and Cyanobacteriamentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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The marine environment represents an outstanding source of antitumoral compounds and, at the same time, remains highly unexplored. Organisms living in the sea synthesize a wide variety of chemicals used as defense mechanisms. Interestingly, a large number of these compounds exert excellent antitumoral properties and have been developed as promising anticancer drugs that have later been approved or are currently under validation in clinical trials. However, due to the high need for these compounds, new methodologies ensuring its sustainable supply are required. Also, optimization of marine bioactives is an important step for their success in the clinical setting. Such optimization involves chemical modifications to improve their half-life in circulation, potency and tumor selectivity. In this review, we outline the most promising marine bioactives that have been investigated in cancer models and/or tested in patients as anticancer agents. Moreover, we describe the current state of development of anticancer marine compounds and discuss their therapeutic limitations as well as different strategies used to overcome these limitations. The search for new marine antitumoral agents together with novel identification and chemical engineering approaches open the door for novel, more specific and efficient therapeutic agents for cancer treatment.

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Section: Bacteria Actinobacteria and Cyanobacteriamentioning

confidence: 99%

From Seabed to Bedside: A Review on Promising Marine Anticancer Compounds

et al. 2020

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“…They can also inhibit enzymes that are important for the maintenance of DNA integrity such as topoisomerases. Chromomycins are tricyclic glycosylated polyketides belonging to the aureolic acid family, with promising anticancer activity and antiproliferative properties (Guimarães et al, 2014;Pettit et al, 2015;Pinto et al, 2019). These molecules bind to the DNA minor groove, causing DNA damage of treated cells, enhancing the expression of apoptosis related genes (Boer et al, 2009;Zihlif et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Targeting the Oncogenic TBX2 Transcription Factor With Chromomycins

et al. 2020

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“…Based on their known activities, aureolic acids have been pursued as anti-cancer chemotherapies. For example, these compounds have been implicated as anti-tumor agents (15,19), inhibitors of Wnt signaling (20) and DNA gyrase (21), as well as autophagy inducers (22,23), although the specific genes and pathways implicated in the mechanism of action of CMA2 and MTM are only just being fleshed out.…”

Section: Introductionmentioning

confidence: 99%