Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress

Reshma, Arunima P.; Arunachalam, Rajeev; Pillai, Jayakumar Kochu; Kurra, Sarath Babu; Varkey, Vini K; Prince, Mohanraj J

doi:10.4103/0972-124x.113076

Cited by 22 publications

(21 citation statements)

References 33 publications

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“…Chromogranin A and its derived peptides have shown promise as biomarkers for cardiovascular diseases such as hypertension, heart failure, myocardial infarction, and coronary syndromes [43–47]. Moreover, saliva CgA has been shown to be a sensitive biomarker for stress in humans and pigs [12, 14, 48–53]. Some evidence suggests that CgA could be useful as a biomarker for neuroendocrine tumors and stress also in dogs [1, 2].…”

Section: Introductionmentioning

confidence: 99%

Catestatin and vasostatin concentrations in healthy dogs

et al. 2017

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BackgroundThe neuroendocrine glycoprotein chromogranin A is a useful biomarker in humans for neuroendocrine tumors and stress. Chromogranin A can be measured in both blood and saliva. The objective of this study was to investigate concentrations of and correlation between the chromogranin A epitopes catestatin and vasostatin in healthy dogs accustomed to the sample collection procedures. Blood and saliva samples were collected from 10 research Beagle dogs twice daily for 5 consecutive days, and from 33 privately-owned blood donor dogs in association with 50 different blood donation occasions. All dogs were familiar with sample collection procedures. During each sampling, stress behavior was scored by the same observer using a visual analog scale (VAS) and serum cortisol concentrations. Catestatin and vasostatin were analyzed using radioimmunoassays for dogs.ResultsThe dogs showed minimal stress behavior during both saliva sampling and blood sampling as monitored by VAS scores and serum cortisol concentrations. Few and insufficient saliva volumes were obtained and therefore only catestatin could be analyzed. Catestatin concentrations differed significantly and did not correlate significantly with vasostatin concentrations (P < 0.0001). Age, gender, breed, and time of sample collection did not significantly affect concentrations of plasma catestatin, vasostatin, and saliva catestatin.ConclusionsThe normal ranges of plasma catestatin (0.53–0.98 nmol/l), vasostatin (0.11–1.30 nmol/l), and saliva catestatin (0.31–1.03 nmol/l) concentrations in healthy dogs accustomed to the sampling procedures were determined. Separate interpretation of the different chromogranin A epitopes from either saliva or plasma is recommended.

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Section: Introductionmentioning

confidence: 99%

Catestatin and vasostatin concentrations in healthy dogs

et al. 2017

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“…This study suggested that chronic psychological stress may influence sCgA secretion via chronic stress-related attenuation of the activity of the sympathetic-adrenomedullary system in healthy adult males. Reshma et al 18 reported that the levels of CgA in the plasma and saliva were elevated in subjects with stress-induced chronic periodontitis. There were inconsistent results of sCgA secretion in response to chronic stress.…”

Section: Resultsmentioning

confidence: 99%

Release Pattern of Salivary Chromogranin A in Pediatric Subjects with Obstructive Sleep Apnea

et al. 2014

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Background and ObjectiveaaSleep-disordered breathing (SDB) is associated with activation of the stress response, including the autonomic nervous system. Salivary chromogranin A (sCgA) is considered a valuable indicator of sympathoadrenal activity. We examined the relationship between sCgA and polysomnography (PSG) parameters. MethodsaaIn this prospective study, we enrolled 103 children who underwent a physical examination and fully attended in-lab PSG. Saliva was collected at night before PSG and in the early morning after PSG. ResultsaaThe subjects (n = 103) were divided into control [n = 41, apnea-hypopnea index (AHI) ≤ 1] and obstructive sleep apnea syndrome (OSAS; n = 62, AHI > 1) groups. The OSAS group was subdivided into mild (1 < AHI ≤ 5), moderate (5 < AHI ≤ 10), and severe (10 < AHI) groups. There was no significant difference in the sCgA parameters between the control and OSAS groups. No significant difference was observed in sCgA parameters between the control group and OSAS subgroups (mild, moderate, and severe). No circadian rhythm was detected in sCgA secretion, and no difference in sCgA concentrations was measured at the two time points. ConclusionsaaOur findings suggest that sCgA secretion was not influenced by OSAS severity and no definitive circadian rhythm was detected in pediatric subjects. Further study is needed to establish whether there is a circadian rhythm in pediatric subjects.

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“…A possible influence of all these factors on our results cannot be completely excluded, since patterns of behavior and genetic polymorphisms were not assessed. Furthermore, sCgA concentrations were described to be affected by several pathologies, such as aggressive [48] or chronic periodontitis [51], bruxism [52], type 2 diabetes [53], or xerostomia (dry mouth) [54]; in general the presence of these pathologies was associated with higher sCgA level. In addition, as our study participants were older subjects, they are administrated a wide variety of medications which may also affect the sCgA secretion.…”

Section: Discussionmentioning

confidence: 99%

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

Valdiglesias

Maseda

Lorenzo-López

et al. 2016

JAD

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Salivary chromogranin A (sCgA) is gaining attention as a biomarker of psychological stress. The objective of this work was to determine whether individualized music intervention and multisensory stimulation environment (MSSE) in a Snoezelen room produce changes in sCgA in severely demented older patients, and to assess the possible existence of differences in sCgA levels between the two types of interventions. Older adults with severe dementia (n = 22) were randomly assigned to two intervention groups. They participated in MSSE or individualized music interventions in 30-min weekly sessions for 16 weeks. Levels of sCgA were evaluated before and after a session, or 30-min interval, at four different time points: before starting the trial, in the middle and end of the intervention period, and two months later. Comparison of sCgA values obtained after each session with those obtained before (or at the same hour in before trial and follow-up samplings) showed no significant differences either in the individualized music or in the MSSE group at any sampling time. Comparison between the two types of interventions, both before and after each session, in the four sampling times, did not produce any significant difference either. Furthermore, no significant correlation was obtained between agitation, anxiety, cognitive function, and dementia severity with sCgA levels. In conclusion, despite beneficial effects of both individualized music and MSSE interventions being previously reported on neuropsychiatric outcomes for older patients with dementia, sCgA seems to not be a good indicator of these benefits.

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Chromogranin A: Novel biomarker between periodontal disease and psychosocial stress

Cited by 22 publications

References 33 publications

Catestatin and vasostatin concentrations in healthy dogs

Catestatin and vasostatin concentrations in healthy dogs

Release Pattern of Salivary Chromogranin A in Pediatric Subjects with Obstructive Sleep Apnea

Is Salivary Chromogranin A a Valid Psychological Stress Biomarker During Sensory Stimulation in People with Advanced Dementia?

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