2013
DOI: 10.3109/01913123.2012.750410
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Chromogranin A and Vesicular Monoamine Transporter 2 Immunolocalization in Protein Bodies of Human Locus Coeruleus Neurons

Abstract: Our previous histochemical and ultrastructural studies have identified, in human catecholamine neurons, abundant spherical acidophilic protein bodies (pb), which originate from regular mitochondria, retaining their double membrane. In locus coeruleus (LC) neurons, pb have somatodendritic distribution and are unequivocal storage vesicles for noradrenaline, as demonstrated by immunolocalization of Dopamine-β-Hydroxylase. In the present study, in order to reinforce the identity of pb as monoamine storage sites in… Show more

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Cited by 3 publications
(3 citation statements)
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“…These neurosecretory granules can be found in multiple cell types, including NE cells, endocrine, exocrine, and hematopoietic cells. They can also be found in neurons . Our study confirms the presence of neurosecretory granules in SCC of the prostate, but presents additional new findings indicating that the transdifferenratiaion goes beyond neuroendocrine into neuronal.…”
Section: Discussionsupporting
confidence: 84%
“…These neurosecretory granules can be found in multiple cell types, including NE cells, endocrine, exocrine, and hematopoietic cells. They can also be found in neurons . Our study confirms the presence of neurosecretory granules in SCC of the prostate, but presents additional new findings indicating that the transdifferenratiaion goes beyond neuroendocrine into neuronal.…”
Section: Discussionsupporting
confidence: 84%
“…In MeCP2-deficient mice, the expression of Nr2f2 is up-regulated, which may down-regulate Chgb and cause excess monoamine accumulation in the extracellular fluid and impair neurons. This finding suggests that influence of MeCP2 deficiency can be aggravated through a downstream target gene cascade in astrocytes ( Kloukina-Pantazidou et al, 2013 ; Delepine et al, 2015 ). Interestingly, in response to LPS stimulation, MeCP2-deficient astrocytes released fewer cytokines such as IL-1β and IL-6 ( Maezawa et al, 2009 ).…”
Section: Mecp2 In Astrocytesmentioning
confidence: 87%
“…Similarly, the procedures using confocal laser microscopy have been performed, but these approaches also do not enable the evaluation of subcellular degeneration using submicrometer resolution of both degenerated neurons and activated microglial cells [13,14]. However, another study aimed to detect degeneration and/or intracellular changes of neurons using electron microscopy has been reported [15][16][17][18][19]. This method is advantageous, in enabling the detection of the subcellular degeneration of neurons because of its resolution.…”
Section: Introductionmentioning
confidence: 97%