Chromoendoscopy with Indigocarmine Improves the Detection of Adenomatous and Nonadenomatous Lesions in the Colon

Abstract

Chromoendoscopy allows easy detection of mucosal lesions in the colon and facilitates visualization of the margins of flat lesions. This technique unmasks multiple mucosal lesions which are not identified by routine video colonoscopy. The pit pattern seen after staining allows differentiation between hyperplastic and adenomatous lesions which may have consequences with regard to the endoscopic interventions needed.

Magnifying colonoscopy used to predict disease relapse in patients with quiescent ulcerative colitis

“…Hence, target biopsies of suspicious lesions might provide more effective surveillance than taking random biopsies. [28][29][30] Hurlstone et al 31,32 reported on the efficacy of magnifying colonoscopy in UC using ''optical biopsy'' for the surveillance of colitic cancer and disease extent. Nishizawa et al 33 first reported the healing process patterns of UC mucosa using the feature of magnifying colonoscopy.…”

Role of chromoendoscopy in colon cancer surveillance in inflammatory bowel disease

“…Types I and II are staining patterns that predict nonneoplastic changes, such as hyperplasia, whereas Types III and IV predict neoplastic alterations ( Table 2). Pit pattern analysis has enabled neoplastic prediction, which may determine appropriate treatment, such as endoscopic or surgical therapy 34,35 based on the results of magnifying chromoendoscopy. 36 A retrospective study using magnifying colonoscopy and dye spraying (indigo carmine) examined the mucosal pit patterns of 3,438 lesions and compared the results to the histopathological examination.…”

In vivo Optical Diagnosis of Polyp Histology: Can We Omit Pathological Examination of Diminutive Polyps?

“…Generally speaking, positive predictive values (PPV) for neoplastic lesion range between 70 to 100% and negative predictive values (NPV) between 70 and 99%. Studies with the largest number of lesions show an overall accuracy of 80-95% [36][37][38]. One study focused in diminutive lesions, reported an overall accuracy of 95% [39].…”