Chromobox Homolog 4 Is Correlated with Prognosis and Tumor Cell Growth in Hepatocellular Carcinoma

Wang, Boqing; Tang, Jianjun; Liao, Dan; Wang, Gang; Zhang, Meifang; Sang, Yi; Jie, Cao; Wu, Yuanzhong; Zhang, Ruhua; Li, Shengping; Ding, Wei; Zhang, Guoqing; Kang, Tiebang

doi:10.1245/s10434-013-3171-7

Cited by 58 publications

(64 citation statements)

References 30 publications

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“…As shown in Fig. 1A, compared with normal tissues, most HCC tissues showed significantly lower expression of miR-195, similar to the findings of Wang et al (3).…”

Section: Mir-195 Is Aberrantly Downregulated In Hcc Tissue Samplessupporting

confidence: 89%

“…HCC is a malignant tumor that is difficult to diagnose as early-stage disease. It is characterized by a high frequency of recurrence, metastasis following surgical resection, and resistance to common chemotherapy and radiotherapy, resulting in poor survival (3,4). Over the past few decades, there have been great advances in the treatment of HCC, yet overall patient survival remains low (5).…”

Section: Introductionmentioning

confidence: 99%

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microRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma

Zheng

Wang

et al. 2015

Oncology Reports

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Abstract. plays important roles in tumor metastasis and angiogenesis, yet its function and mechanism of action in hepatocellular carcinoma (HCC) remain to be elucidated. In this study, we aimed to confirm whether chromobox homolog 4 (CBX4) is a direct target gene of miR-195 and determine the functions of miR-195 through the CBX4 pathway. miR-195 expression was slightly lower in the HCC tissues compared with that in the adjacent normal tissues. In addition, western blotting and qRT-RCR results showed that both CBX4 mRNA and protein levels were downregulated upon miR-195 overexpression. Luciferase reporter assays revealed that CBX4 is a direct target gene of miR-195. Furthermore, overexpression of CBX4 significantly restored the proliferative, invasive and migratory capacities of the HepG2 cells. Finally, in vivo experiments confirmed that high expression of CBX4 in HepG2 cells promoted tumor growth.In conclusion, our study demonstrated that miR-195 acts as a tumor suppressor by directly targeting CBX4 in HCC. This finding suggests a potential novel strategy for therapeutic interventions of this disease.

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“…As shown in Fig. 1A, compared with normal tissues, most HCC tissues showed significantly lower expression of miR-195, similar to the findings of Wang et al (3).…”

Section: Mir-195 Is Aberrantly Downregulated In Hcc Tissue Samplessupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

microRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma

Zheng

Wang

et al. 2015

Oncology Reports

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“…Hepatocellular carcinoma patients whose tumors contain high CBX4 levels have a shorter overall survival and CBX4 knockdown in hepatocellular carcinoma cell lines elevated INK4A levels and reduced proliferation. 146 In addition, CBX4 promotes angiogenesis by its SUMO E3 ligase activity, an enzymatic ability that is unique among Pc-CBX proteins. 147,148 CBX8 was demonstrated to repress genes necessary for leukemic transformation, which is counteracted by the MLL-ENL fusion oncoprotein in MLL leukemia.…”

Section: Large Diversification Of Prc1 Complexes and Their Cancer Conmentioning

confidence: 99%

Context-dependent actions of Polycomb repressors in cancer

Koppens

Lohuizen

2015

Oncogene

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Polycomb Group (PcG) proteins form Polycomb Repressive Complexes (PRCs) that function as epigenetic repressors of gene expression. The large variety of PcG proteins, in addition to the high number of paralogs, allows for the formation of diverse PRCs with different properties, providing fine-tuned control over cell specification. Initially identified as being oncogenes, a small number of PcG genes are involved in tumor development in part through the repression of the CDKN2A locus. Therefore, enhanced PcG-mediated repression has long been assumed to be cancer promoting. However, recent data have revealed that for some cancers, PcG proteins act as tumor suppressors, indicating that this traditional view is oversimplified. In this review, we present an overview of the roles of PcG genes in oncogenesis and how the nature of their role is context dependent.

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“…Colon Diagnosis, prognosis [61] Gastric Diagnosis, prognosis, therapeutic predictivity [62,63] Prostate Diagnosis [64] Breast Prognosis [44] PIAS3 Lung, breast, prostate, colorectal, brain Diagnosis [65,66] Ovarian, endometrial Diagnosis [67] Squamous cell carcinoma of the lung Diagnosis [68] Gastric Diagnosis, prognosis [69] PIAS4 Gastric Therapeutic predictivity [63] Breast Prognosis [70] MDS Diagnosis, progression [71] RanBP2 Multiple myeloma Diagnosis [72] Small cell lung cancer Diagnosis [73] Inflammatory myofibroblastic tumor Diagnosis, prognosis, therapeutic predictivity, risk assessment [74,75] Acute myelomonocytic leukemia Diagnosis, risk assessment [76,77] 8p11 myeloproliferative syndrome Diagnosis, risk assessment [78] Pc2 Hepatocellular carcinoma Prognosis [79] TRIM19 AML Diagnosis [80] TRIM27 Endometrial Prognosis [81] Colon Prognosis [82] Ovarian Prognosis, therapeutic predictivity [83] SENP1 Prostate Diagnosis, prognosis, therapeutic predictivity [84][85][86] Pancreatic ductal adenocarcinoma Diagnosis, prognosis [87] SENP2 Bladder Diagnosis [88] Hepatocellular carcinoma Diagnosis [89] SENP3 Colon, rectum, ovarian, lung, oral squamous cell carcinoma Diagnosis [90,91] …”

Section: Pias1mentioning

confidence: 99%

SUMO pathway components as possible cancer biomarkers

Mattoscio

Chiocca

2015

Future Oncology

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SUMOylation is a key post-translational modification that regulates crucial cellular functions and pathological processes. Recently, Small Ubiquitin-related MOdifier (SUMO) modification has emerged as a fundamental route that may drive different steps of human tumorigenesis. Indeed, alteration in expression or activity of one of the different SUMO pathway components may completely subvert cellular properties through fine-tuning modulation of protein(s) involved in carcinogenic pathways, leading to altered cell proliferation, apoptosis resistance and metastatic potential. Here we describe some of the most interesting findings pointing to a clear link between SUMO pathway and human malignancies. Importantly, a putative role for SUMO enzymes to predict cancer behavior can be speculated, and thus the possible application of alterations in SUMO pathway components as tumor biomarkers is discussed.

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Chromobox Homolog 4 Is Correlated with Prognosis and Tumor Cell Growth in Hepatocellular Carcinoma

Abstract: The cytoplasmic CBX4 protein may be a useful prognostic biomarker and a potential therapeutic target for HCC.

Cited by 58 publications

References 30 publications

microRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma

microRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma

Context-dependent actions of Polycomb repressors in cancer

SUMO pathway components as possible cancer biomarkers

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