Chromobacterium violaceum infection in chronic granulomatous disease: a case report and review of the literature

Meher-Homji, Zaal; Mangalore, Rekha Pai; Johnson, Paul D R; Chua, Kyra

doi:10.1099/jmmcr.0.005084

Cited by 31 publications

(33 citation statements)

References 20 publications

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“…Other bacteria found in soil and brackish water that uncommonly cause disease in healthy individuals but are more common pathogens in CGD are Granulibacter bethesdensis, Chromobacterium violaceum, and Francisella philomiragia. [43][44][45] While most of the cases of Chromobacterium violaceum within the US have been primarily described in the southeastern United States, this facultatively anaerobic, Gram-negative bacillus can also be found in tropical and sub-tropical soil worldwide. 44,46 Granulibacter bethesdensis, a fastidious Gram-negative organism that causes indolent lymphadenitis and splenitis in CGD occurs in the US and Europe, but its natural reservoir is unknown.…”

Section: Pathogen Variability Within the United Statesmentioning

confidence: 99%

“… 43 – 45 While most of the cases of Chromobacterium violaceum within the US have been primarily described in the southeastern United States, this facultatively anaerobic, Gram-negative bacillus can also be found in tropical and sub-tropical soil worldwide. 44 , 46 Granulibacter bethesdensis , a fastidious Gram-negative organism that causes indolent lymphadenitis and splenitis in CGD occurs in the US and Europe, but its natural reservoir is unknown. 45 …”

Section: Pathogen Variability Within the United Statesmentioning

confidence: 99%

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<p>Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease</p>

Prince¹,

Thielen²,

Williams³

et al. 2020

PHMT

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Chronic granulomatous disease (CGD) is a rare but serious primary immunodeficiency with varying prevalence and rates of X-linked and autosomal recessive disease worldwide. Functional defects in the phagocyte nicotinamide adenine dinucleotide phosphate oxidase complex predispose patients to a relatively narrow spectrum of bacterial and fungal infections that are sometimes fastidious and often difficult to identify. When evaluating and treating patients with CGD, it is important to consider their native country of birth, climate, and living situation, which may predispose them to types of infections that are atypical to your routine practice. In addition to recurrent and often severe infections, patients with CGD and X-linked female carriers are also susceptible to developing many non-infectious complications including tissue granuloma formation and autoimmunity. The DHR-123 oxidation assay is the gold standard for making the diagnosis and it along with genetic testing can help predict the severity and prognosis in patients with CGD. Disease management focuses on prophylaxis with antibacterial, antifungal, and immunomodulatory medications, prompt identification and treatment of acute infections, and prevention of secondary granulomatous complications. While hematopoietic stem-cell transplantation is the only widely available curative treatment for patients with CGD, recent advances in gene therapy may provide a safer, more direct alternative.

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Section: Pathogen Variability Within the United Statesmentioning

confidence: 99%

Section: Pathogen Variability Within the United Statesmentioning

confidence: 99%

<p>Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease</p>

Prince¹,

Thielen²,

Williams³

et al. 2020

PHMT

View full text Add to dashboard Cite

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“…We found that 9 out of 16 patients did see a healthcare provider (56%) with one of them having been previously hospitalized before being transferred to another facility. and 9 of those 10 patients received antibiotics (56%) [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] .…”

Section: Discussionmentioning

confidence: 99%

Lemierre’s syndrome: Case report and brief literature review

Zhao

Samannodi²,

Tahir³

et al. 2017

IDCases

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Lemierre’s syndrome has been shown to be increasing in incidence in the past 20 years with one popular suggesting that said rise occurred from less aggressive antibacterial coverage. We report a case of Lemierre’s syndrome and also reviewed the 15 most recent case reports. A previously healthy 25 year old male who initially developed sore throat and flu-like symptoms, was prescribed antibacterials as an outpatient but was hospitalized for worsening symptoms. He was later diagnosed with Lemierre’s syndrome and improved clinically with IV antimicrobials alone. From our concise literature review, we determined that a decrease in antibiotic prescriptions may not fully explain why the incidence of Lemierre’s has been increasing. Thus, future research should be focused in evaluating possible worsening susceptibilities to antibiotics and improvements on detection. We also advise physicians to be aware of the signs and symptoms of this rare but potentially fatal condition as well as the available detection methods and treatment

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“…22 Cases of C. violaceum infection in humans have been reported from Australia, India, Nepal, USA, Brazil, and Congo. [23][24][25][26][27][28][29][30][31] There have been about 150 cases reported worldwide. 4 and mortality rate in such cases is found to be high (53%).…”

Section: Clinical Reportsmentioning

confidence: 99%

Review on Chromobacterium violaceum, a Rare but Fatal Bacteria Needs Special Clinical Attention

Sharmin¹,

Kamal²

2019

Anwer Khan Mod Med Coll J

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Chromobacterium violaceum is isolated from soil and water in tropical and subtropical areas. This Gram negative, capsulated, motile bacillus is considered as a saprophyte but occasionally it can act as an opportunistic pathogen for animals and human. It causes skin lesion with liver and lung abscesses, pneumonia, gastrointestinal tract infections, urinary tract infections, osteomyelitis, meningitis, peritonitis, endocarditis, respiratory distress syndrome and septic shock. Increasing reported cases with Chrombacterium violaceum infection has been noticed in recent decades. It should be considered for its difficult-to-treat entity characterized by a high frequency of sepsis, distantant metastasis, multidrug resistance and relapse. High mortality rate associated with this infection necessitate prompt diagnosis and appropriate antimicrobial therapy Anwer Khan Modern Medical College Journal Vol. 10, No. 2: July 2019, P 169-175

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Chromobacterium violaceum infection in chronic granulomatous disease: a case report and review of the literature

Cited by 31 publications

References 20 publications

<p>Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease</p>

<p>Geographic Variability and Pathogen-Specific Considerations in the Diagnosis and Management of Chronic Granulomatous Disease</p>

Lemierre’s syndrome: Case report and brief literature review

Review on Chromobacterium violaceum, a Rare but Fatal Bacteria Needs Special Clinical Attention

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