Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh

Hossain, M.M. Aeorangajeb Al; Yajima, Ichiro; Kato, Masaya; Xu, Hongbing; Saheduzzaman,; Ohgami, Nobutaka; Ahsan, Nazmul; Akhand, Anwarul A.

doi:10.1016/j.chemosphere.2019.04.112

Cited by 22 publications

(7 citation statements)

References 25 publications

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“…4 Chromium sulphate, N-diphenylguanidine, benzidine and sodium metabisulfite were demonstrated as sensitizing agent to the exposed workers. 12 Chromium induced hyper-pigmentation of skin was reported by Al-Hossain et al, 38 A study found chromate as frequent allergen to tannery workers that increased serum immunoglobulin E (IgE) level. 39 Workers are exposed to the chemicals while loading, unloading, handling and discarding.…”

Section: Discussionmentioning

confidence: 94%

Prevalence of Occupational Skin Diseases and its Predisposing Factors in Leather Tanning Workers of Southern India

Karunamoorthy¹,

Mani²,

Ravichandran³

et al. 2020

Curr. World Environ

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Skin diseases are a major occupational health issue in tannery workers because of work related exposure to various toxic chemicals used in tanning process. In the present study, prevalence of various skin diseases and predisposing factors in tannery workers were investigated.A cross sectional study including 114 tannery workers (male-89; female-25) employed at different tanneries of Southern India was carried out. Face to face interview with pre-designed questionnaire and health examination was conducted. Skin samples obtained from the participants were subjected to microscopic examination and microbial culture for diagnosis of skin diseases. The prevalence of occupational skin disorders were 39% among the study participants. Contact dermatitis (16%), skin infections (16%), eczematous lesions (7%) and nail discoloration (1.75%) wereidentified. Skin infections of fungal origin were identified among 11.4% of subjects. The skin infections of fungi; tenia corporis, tenia cruris, tenia unguium, tenia versicolor, tenia pedis and Pityriosis versicolor were identified. Bacterial skin infections identified were associated with contact dermatitis. Lack of PPE usage was reported among 30% of workers. Hazardous working environment, chemical exposure, humidity and lack of PPEusage were significantly associated with increased skin disease incidence(p<0.05), indicating the major predisposing factorsfor Occupation skin diseases.The findings of the study emphasize that,workers in the pre-tanning section and tanning sections are more vulnerable to occupational skin diseases.Compliance to use of PPEs, engineering controls to reduce exposure, education, frequent health surveillance and early identification & treatment could mitigate the occupational skindiseasesamongtannery workers.

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Section: Discussionmentioning

confidence: 94%

Prevalence of Occupational Skin Diseases and its Predisposing Factors in Leather Tanning Workers of Southern India

Karunamoorthy¹,

Mani²,

Ravichandran³

et al. 2020

Curr. World Environ

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“…Ni has been widely detected in cosmetic products, together with Co and Cr, among others [ 8 , 58 ]. The attention paid to Ni, Co, and Cr is based mainly on skin conditions, such as contact allergic dermatitis, itching, and edema, among others [ 59 , 60 , 61 , 62 , 63 , 64 ]. What is more, these elements can be solubilized by sweat during prolonged contact [ 60 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Safety of Nanoclay/Spring Water Hydrogels: Assessment and Mobility of Hazardous Elements

et al. 2020

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The presence of impurities in medicinal products have to be controlled within safety limits from a pharmaceutical quality perspective. This matter is of special significance for those countries and regions where the directives, guidelines, or legislations, which prescribe the rules for the application of some products is quite selective or incomplete. Clay-based hydrogels are quite an example of this matter since they are topically administered, but, in some regions, they are not subjected to well-defined legal regulations. Since hydrogels establish an intimate contact with the skin, hazardous elements present in the ingredients could potentially be bioavailable and compromise their safety. The elemental composition and mobility of elements present in two hydrogels have been assessed. Sepiolite, palygorskite, and natural spring water were used as ingredients. The release of a particular element mainly depends on its position in the structure of the hydrogels, not only on its concentration in each ingredient. As a general trend, elements’ mobility reduced with time. Among the most dangerous elements, whose presence in cosmetics is strictly forbidden by European legal regulations, As and Cd were mobile, although in very low amounts (0.1 and 0.2 μg/100 g of hydrogel, respectively). That is, assuming 100% bioavailability, the studied hydrogels would be completely safe at normal doses. Although there is no sufficient evidence to confirm that their presence is detrimental to hydrogels safety, legally speaking, their mobility could hinder the authorization of these hydrogels as medicines or cosmetics. In conclusion, the present study demonstrates that hydrogels prepared with sepiolite, palygorskite, and Alicún spring water could be topically applied without major intoxication risks.

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“…Fieldwork studies focusing on well drinking water have been performed in Asian countries including Bangladesh [8][9][10][11], Vietnam [6,12], Malaysia [7], and Afghanistan [13]. Those studies showed that arsenic levels exceeded the WHO health-based guideline level for drinking water in these countries, suggesting that well drinking water is polluted with arsenic in large areas of Asian countries.…”

Section: Comprehensive Studies On Arsenic Environmental Monitoring Fomentioning

confidence: 99%

“…As the first step, environmental monitoring for well drinking water is essential to identify toxic elements contaminating in well water. In fact, elevated concentrations of toxic elements including arsenic, barium, manganese, iron, and uranium in well water were identified by our environmental monitoring in developing countries in Asia [6][7][8][9][10][11][12][13]. After considering the health risks for known toxic elements according to the healthbased guideline levels for drinking water developed by WHO (World Health Organization), we could issue a global alert.…”

Section: Introductionmentioning

confidence: 98%

“…However, element-originating diseases are supposed to be caused by exposure to unknown toxic elements that have no guideline values. Moreover, identification of novel element-originating diseases is not easy since most of the diseases are chronically developed and progressed [3,8,11]. Thus, an alert for known toxic elements in drinking water is insufficient to prevent the development of element-originating diseases.…”

Section: Introductionmentioning

confidence: 99%

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Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

Kato

Ohgami

Ohnuma³

et al. 2020

Environ Health Prev Med

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Well water could be a stable source of drinking water. Recently, the use of well water as drinking water has been encouraged in developing countries. However, many kinds of disorders caused by toxic elements in well drinking water have been reported. It is our urgent task to resolve the global issue of element-originating diseases. In this review article, our multidisciplinary approaches focusing on oncogenic toxicities and disturbances of sensory organs (skin and ear) induced by arsenic and barium are introduced. First, our environmental monitoring in developing countries in Asia showed elevated concentrations of arsenic and barium in well drinking water. Then our experimental studies in mice and our epidemiological studies in humans showed arsenic-mediated increased risks of hyperpigmented skin and hearing loss with partial elucidation of their mechanisms. Our experimental studies using cultured cells with focus on the expression and activity levels of intracellular signal transduction molecules such as c-SRC, c-RET, and oncogenic RET showed risks for malignant transformation and/or progression arose from arsenic and barium. Finally, our original hydrotalcite-like compound was proposed as a novel remediation system to effectively remove arsenic and barium from well drinking water. Hopefully, comprehensive studies consisting of (1) environmental monitoring, (2) health risk assessments, and (3) remediation will be expanded in the field of environmental health to prevent various disorders caused by environmental factors including toxic elements in drinking water.

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Chromium-mediated hyperpigmentation of skin in male tannery workers in Bangladesh

Cited by 22 publications

References 25 publications

Prevalence of Occupational Skin Diseases and its Predisposing Factors in Leather Tanning Workers of Southern India

Prevalence of Occupational Skin Diseases and its Predisposing Factors in Leather Tanning Workers of Southern India

Safety of Nanoclay/Spring Water Hydrogels: Assessment and Mobility of Hazardous Elements

Multidisciplinary approach to assess the toxicities of arsenic and barium in drinking water

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