Chromium

Stoecker, Barbara J.

doi:10.1002/9783527619634.ch28

Cited by 11 publications

(5 citation statements)

References 120 publications

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“…Chromium is a common heavy metal naturally occurring in soil, plants, animals and gases (Pandey and Madhuri, 2014). It exists mainly in two valence states: trivalent chromium (Cr(III)) and hexavalent chromium (Cr(VI)) (Genchi et al, 2021).Although Cr(III) is essential for human and animal diet, with little or no toxicity, its hexavalent form Cr(VI) is 100 to 1000 times more toxic (Stoecker, 2004). Cr AIM OF THE WORK Based on the above literature, the current study was designed to elucidate the possible beneficial effect of selenium on structural damage induced by PDC on the epididymis, prostate and seminal vesicles, and to investigate the underlying mechanistic role of oxidative stress, NF-κB modulation and autophagic responses.…”

Section: Introduction He Increasing Prevalence Of Male Infertility Ha...mentioning

confidence: 99%

Selenium Could Alleviate Potassium Dichromate-Induced Epididymal, Prostatic and Seminal Vesicle Changes in Adult Rats: Potential Role of Inhibiting NF-κB Pathway

Morsy¹,

Hassan²,

Alabassery³

et al. 2023

Egyptian Society of Clinical Toxicology Journal

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Background: Chromium is generated as a waste product from different industries. Its reproductive toxicity has been addressed in many studies that considered oxidative stress the main contributing factor for such toxicity. Selenium is essential for male reproductive health and crucially involved in regulation of cellular redox status. Aim: To elucidate the potential impacts of potassium dichromate (PDC) on the structure of the epididymis, prostate and seminal vesicles and to investigate the efficacy of selenium on counteracting these impacts. Methods: Thirty-six adult male rats were assigned into four groups: control, selenium, PDC, and PDC+selenium. The animals were subjected for a treatment period of four weeks. At the end of experimental period, blood and semen samples, epididymides, prostates and seminal vesicles were collected and processed for biochemical, morphological and immunohistochemical analyses. Results: PDC administration significantly deteriorated sperm parameters and triggered alteration of cellular redox homeostasis, evidenced by increased serum malonaldehyde levels with decreased enzymatic activity of the antioxidants: superoxide dismutase and catalase. Furthermore, PDC significantly unregulated the expression of the serum inflammatory markers; nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha and interleuken-1beta. Microscopically, all the examined tissues of PDC-treated rats displayed deteriorated microarchitecture as well as elevated 8-hydroxy-2-deoxyguanosine and microtubuleassociated protein light chain3 immunoexpression, indicating increased oxidative DNA damage and autophagy activity. Selenium supplements to PDC-treated rats effectively alleviated all the tested parameters. Conclusion: Selenium supplements could effectively mitigate PDC-induced damage of the epididymis, prostate and seminal vesicles through counteracting oxidative stress, and reducing NF-κB activation and excessive autophagy evoked by PDC.

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Section: Introduction He Increasing Prevalence Of Male Infertility Ha...mentioning

confidence: 99%

Selenium Could Alleviate Potassium Dichromate-Induced Epididymal, Prostatic and Seminal Vesicle Changes in Adult Rats: Potential Role of Inhibiting NF-κB Pathway

Morsy¹,

Hassan²,

Alabassery³

et al. 2023

Egyptian Society of Clinical Toxicology Journal

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“…Chromium is found in many compounds of the Earth's crust (Stoecker, 2004). It exists in several oxidation states, but Cr III and Cr VI species are the most stable and common forms (O' Brien et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

“…Chromium III is essential for human and animal diet, it is poor soluble, with little or no toxicity. In its hexavalent form chromium is 100 to 1000 times more toxic than the most trivalent compounds (Stoecker, 2004).…”

Section: Introductionmentioning

confidence: 99%

The outcome of potassium dichromate exposure on histological structure of male rat sexual organs in suckling period

et al. 2020

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The aim of this study was the evaluation of integrity biomarkers of reproductive toxicity: histoarchitecture of genital organs (testis and epididymis) and sexual accessory glands (prostate, seminal vesicles and bulbo-urethral glands) at sexual maturity after exposure to potassium dichromate (Cr VI) in suckling period. Consequent to the exposure of male rat pups to hexavalent chromium during suckling period structural changes appeared in genital organs and sexual accessory glands, such as: basal membrane and epithelial disintegration, interstitial edema, wavy basal membrane due to a reduction in tubule diameter, Leydig cell necrosis; epithelial smoothing, epithelial necrosis; epithelial cells desquamation and falling in lumen. Exposure to potassium dichromate (Cr VI) during suckling period produced severe congestive and degenerative lesions in genital organs and sexual accessory glands.

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“…It is well-known that Cr can exist in a series of oxidation states (−2 to +6); among these, trivalent (Cr-III) and hexavalent (Cr-VI) compounds are thought to be the biologically most significant. Because of its strong oxidizing property, Cr-VI is believed to be 100–1000 times more toxic than the trivalent form (Cr-III) (Stoecker, 2004; Von and Liu, 1993). The acute and chronic effects of Cr have already been reported including dermato-toxicity, neurotoxicity, genotoxicity, immunotoxicity, and carcinogenicity (Li et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

2019

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The populations of wild animals are declining in many parts of the world in response to man-made alterations in the environment. Environmental contamination due to heavy metals discharge from industry may contribute to the decline of wild animal populations by impacting their reproduction, growth, and development. In the leather tanning industry, chromium (Cr) is used as a basic component, but it is a potent toxicant that can affect many of the physiological functions of animals. In the current study, we investigated the reproductive toxicity of industrial Cr in female small Indian mongooses inhabiting a tannery area. Adult female specimens were live trapped from February 2015 to January 2016. Blood and other body tissues (ovaries, kidneys and liver) of the captured specimens were collected along with soil and water samples from the environment for analysis. The Cr concentrations were found significantly (p < 0.0001) increased compared to control in the environment, blood, and all body tissues of the animals. Estradiol and progesterone levels were found to be significantly decreased in comparison with control (p < 0.0001), along with reduced ovarian weights, while follicle stimulating hormone (FSH) and luteinizing hormone levels were found significantly (p < 0.0001) elevated. Light microscopy revealed significantly decreased in comparison with control ovarian follicle numbers (p < 0.0001) and diameters, vacuolization of the oocytes, and a significantly higher percentage of atretic follicles inside the ovary. We conclude that Cr discharged from the tanneries is absorbed by the exposed female small Indian mongoose, leading to ovarian dysfunction with potential impairment of reproductive function.

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Chromium

Cited by 11 publications

References 120 publications

Selenium Could Alleviate Potassium Dichromate-Induced Epididymal, Prostatic and Seminal Vesicle Changes in Adult Rats: Potential Role of Inhibiting NF-κB Pathway

Selenium Could Alleviate Potassium Dichromate-Induced Epididymal, Prostatic and Seminal Vesicle Changes in Adult Rats: Potential Role of Inhibiting NF-κB Pathway

The outcome of potassium dichromate exposure on histological structure of male rat sexual organs in suckling period

Environmental chromium from the tannery industry induces altered reproductive endpoints in the wild female small Indian mongoose (Urva auropunctatus)

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