Chromium in Health and Longevity

Iskra, R.; Antonyak, Halyna

doi:10.1007/978-3-030-03742-0_5

Cited by 5 publications

(6 citation statements)

References 130 publications

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“…An increase in concentration of ceruloplasmin, haptoglobin, and sialic acids and hexoses bound to proteins in the blood of the calves of the experimental groups compared to the control indicates the activation of immunobiological reactivity of their body both during the period of separate feeding of NTC ME in group II and its combination with MCS in group III. Data from the literature indicate that the differences in the action of NTC ME compared to inorganic salts are due to their increased physiological activity and intensity of absorption in the alimentary canal (Borisevich et al, 2010;Vlizlo et al, 2018;Iskra & Antonyak, 2018). In particular, adding Cr, Se, Co, and Zn NTCs to cows' diet stimulated liver protection, the exchange of Ca, P, vitamin E, and the secretory function of the mammary gland (Khomyn et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

Immunobiological reactivity of calf body during the compatible application of nanotechnological citrates of trace elements in the ration

Vlizlo,

Fedoruk,

Kovalchuk

et al. 2023

Biol. Stud.

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Background. Nanotechnology in animal husbandry is an important area of research and development, which includes environmental sustainability, human health and food security. Nanotechnology has the potential to solve many questions related to animal health, production, reproduction, good hygienic practices during rearing and maintaining of animals. Therefore, the research aimed to find out the biological effect of separate and combined feeding of nanotechnological citrates that show high physiological activity in doses much lower than their mineral salts. Materials and Methods. The research was conducted on 15 heifers and bulls divided into three groups five days after birth: control (I) and experimental (II, III) ones, five animals in each. Calves of group I received 240 kg of natural milk with the addition of a mineral-concentrate supplement (MCS) and grass hay for 60 days. Calves of group II were fed similar feed to that of group I with the replacement of MCS with a nutritionally equivalent quantity of cereal grains and soybeans and the introduction of nanotechnological citrates of microelements (NTC ME) I, Se, Cr, Cu, Co, Mn, Zn, Fe into milk in the proportion of 10 %. Calves of group III were fed with a complex of feeds of group I, adding 10 % of NTC ME. Physiological and biochemical indicators of blood and wool of calves were studied on the 10th, 40th and 70th days of growing period. Results. Statistically significant changes in the immunobiological indicators of the blood of calves of group II were found with an increase in the concentration of circulating immune complexes, haptoglobin, and sialic acids in the blood on the 40th day and ceruloplasmin, sialic acids, hexoses bound to proteins and chromium on the 70th day. An increase in the detoxification function of the calves’ liver was recorded, with an increase in the blood level of phenol sulfates by 11.2 % and phenol glucuronides by 18.8% during this period. The combined use of 10 % NTC microelements and MCS in feeding calves of group III led to a statistically significant increase in the blood content of circulating immune complexes, phenol sulfates, phenol glucuronides, and zinc on the 40th and 70th days compared to their level in animals of the control group. Body weight gain in calves of group II was higher by 7.7 %, and in group III – by 4.3 % compared to the control. Conclusion. The addition of NTC ME in the amount of 10 % of the rationed food for these elements to the milk for calves of group II, with the exclusion of the mineral-concentrate supplement from the feeding scheme, led to the activation of the immunobiological reactivity of the organism. The combined use of 10 % of NTC ME and mineral-concentrate supplement in the diet of calves of group III resulted in a lesser immunobiological reactivity of the organism, and strengthened the detoxification ability of the body.

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Section: Resultsmentioning

confidence: 99%

Immunobiological reactivity of calf body during the compatible application of nanotechnological citrates of trace elements in the ration

Vlizlo,

Fedoruk,

Kovalchuk

et al. 2023

Biol. Stud.

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“…These conclusions were produced based on the analysis of > 50000 patients, > 1900 dosage forms and > 300 clinical trials linked in a single alignment presented earlier (Tables 1 and 2). The mechanisms at the highest tier of database signals in Table 1 and Files A-C in S1 Data (Mg+2, Zn+2, Se, biotin, chromium picolinate, vitamin A-lutein) are traditionally prescribed as life-extending or preventing retinal degeneration and substantial evidence of mechanistic involvement or clinical efficiency are available for each, including successful controlled clinical trials or successful treatment of organic neurological conditions in humans, based on incremental definition of "success" ( [63][64][65][66][67][68][69][70][71][72], Tables 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy

Mayburd

Koivogui²,

Baranova

2019

PLoS ONE

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Preventive treatments for dementia are warranted. Here we show that utilization of certain combinations of prescription medications and supplements correlates with reduced rates of cognitive decline. More than 1,900 FDA-approved agents and supplements were collapsed into 53 mechanism-based groups and traced in electronic medical records (EMRs) for >50,000 patients. These mechanistic groups were aligned with the data presented in more than 300 clinical trials, then regression model was built to fit the signals from EMRs to clinical trial performance. While EMR signals of each single agents correlated with clinical performance relatively weakly, the signals produced by combinations of active compounds were highly correlated with the clinical trial performance (R = 0.93, p = 3.8 x10^-8). Higher ranking pharmacological modalities were traced in patient profiles as their combinations, producing protective complexity estimates reflecting degrees of exposure to beneficial polypharmacy. For each age strata, the higher was the protective complexity score, the lower was the prevalence of dementia, with maximized life-long effects for the highest regression score /diversity compositions. The connection was less strong in individuals already diagnosed with cognitive impairment. Confounder analysis confirmed an independent effect of protective complexity in multivariate context. A sub-cohort with lifelong odds of dementia decreased > 5-folds was identified; this sub-cohort should be studied in further details, including controlled clinical trials. In short, our study systematically explored combinatorial preventive treatment regimens for age-associated multi-morbidity, with an emphasis on neurodegeneration, and provided extensive evidence for their feasibility.Funding: AM is the Founder of Neurocombinatorix LLC, and MK is affiliated with the organization. Neurocombinatorix LLC does not conduct commercial activity and did not provide any funds for research. The authors volunteered to the effort without any salaries, no other parties have a role in the study design, data collection and analysis, Recent decreases in the rate of dementia and a shift to later ages of onset are encouraging [4]. However, in a first quartile of life expectancy, dementia still accounts for 1 in every 6 deaths, and is a major source of disability [1]. While multiple clinical trials for single dementia combating agents are ongoing [5], earlier stages of neurodegeneration process largely remain unexplored in humans.On the other hand, recent studies in model animals are encouraging. Particular successful efforts in visible rejuvenation of already differentiated tissues are reviewed in [6]). NAD+ supplementation has been associated with an extension of murine lifespan by 10-15% [7,8] through the mechanism likely related to overall brain function. The maintenance of microvasculature [9,10], the clearance of misfolded proteins [11], the neuroprotection [12,13], and the regulation of cholinesterase [13] were shown to be comparably important for the prevention...

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“…Rats received daily doses of PGZ, Cr-PL, and Cr-GTF and their combinations through gastric gavage between 8:00 and 10:00 am to guarantee precise digestion. [ 10 ]…”

Section: Methodsmentioning

confidence: 99%

“…[ 15 ] A prior animal study showed that the Cr maximum safe dosage of 1 mg/kg (rat weight)/day was utilized safely and effectively. [ 10 ] To achieve correct dosing, rats were gastric-gavaged daily with PGZ, Cr-PL, Cr-GTF, and combinations between 8:00 and 10:00 a.m. The five experimental groups of rats were sorted and given Cr-PL, Cr-GTF, and PGZ in the following combinations:…”

Section: Methodsmentioning

confidence: 99%

Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions

AlTamimi,

Zakaraya,

Hailat

et al. 2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Type 2 diabetes is common globally. Pioglitazone (PGZ) is an oral TZD antidiabetic, whereas chromium-picolinate (Cr-PL) and Cr-glucose tolerance factor (Cr-GTF) are useful type 2 diabetes mellitus (T2DM) supplements. Cr-PL/GTF antioxidants cure T2DM. They may fail in diabetes with or without insulin-sensitizing medications. It examined how Cr-PL, Cr-GTF, PGZ, and their combination affected glucose, glycosylated hemoglobin, insulin, and HOMA-IR. Sixty-three adult Sprague-Dawley rats (220–300 g) were selected, and nine rats were randomly assigned to a normal nondiabetic group. In contrast, 54 rats were randomly split into 9 rats per each of the 6 major groups and injected intraperitoneally with 40 mg/kg STZ to induce T2DM. Rats were administered PGZ = 0.65 mg/kg (rat weight)/day, Cr-PL = 1 mg/kg, Cr-GTF = 1 mg/kg, and their combinations (PGZ + Cr-PL and Cr-GTF) daily for 6 weeks per intervention. The PGZ + Cr-PL and PGZ + Cr-GTF groups had substantially lower insulin levels than the PGZ group (13.38 ± 0.06, 12.98 ± 0.19 vs. 14.11 ± 0.02, respectively), with the PGZ + Cr-GTF group having the lowest insulin levels (12.98 ± 0.19 vs. 14.11 ± 0.02, 13.38±0.06, respectively). Intervention substantially reduced HOMA-IR in the PZ + Cr-PL and PZ + Cr-GTF groups compared to PGZ (7.49 ± 0.04, 6.69 ± 0.11 vs. 8.37 ± 0.04, respectively). This research found that combining PGZ with Cr-GTF resulted in considerably lower HOMA-IR levels than the PGZ and Cr-PL groups (6.69 ± 0.11 vs. 8.37 ± 0.04, 7.49 ± 0.04, respectively). Both Cr-PL and Cr-GTF may control T2DM. Both Cr complexes improved T2DM biomarkers more than the control diabetic group without medication. PGZ alone and PGZ + Cr-PL had less pharmacological synergy than Cr-GTF and PGZ in altering insulin and HOMA-IR blood levels. These encouraging discoveries need more study.

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Chromium in Health and Longevity

Cited by 5 publications

References 130 publications

Immunobiological reactivity of calf body during the compatible application of nanotechnological citrates of trace elements in the ration

Immunobiological reactivity of calf body during the compatible application of nanotechnological citrates of trace elements in the ration

Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy

Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions

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