Chromium and Manganese Levels in Biological Samples of Pakistani Myocardial Infarction Patients at Different Stages as Related to Controls

Abstract

It has been speculated that trace elements may play a role in the pathogenesis of heart diseases In the present study, we aimed to access the levels of chromium (Cr) and manganese (Mn) in biological samples (whole blood, urine, and scalp hair) of myocardial infarction (MI) patients of both gender age ranged (45-60 years) at first, second, and third heart attack (n = 130), hospitalized in cardiac ward of National Hospital of Hyderabad city (Pakistan). For comparison, healthy age-matched referent subjects (n = 61), of both gender were also selected. The Cr and Mn in biological samples were measured by electrothermal atomic absorption spectrometry, prior to microwave-assisted acid digestion. The validity of the methodology was checked by the biological certified reference materials. During this study, 78% of 32 registered patients of third MI attack (aged >50 years) were died. In these subjects the concentration of Cr and Mn were decreased by 24.7% and 19.8% in scalp hair, while in blood samples 17.9% and 12.4%, respectively, as compared to those who tolerated third MI attack (p = 0.063). Although these data do not prove a causal relationship, these results are consistent with the hypothesis that heart disease may cause deficiencies of certain essential trace elements. The excretion levels of Cr and Mn in urine samples of first MCI were higher than controls at p values (0.029 and 0.011), respectively, whereas the excretion rates of both elements were further enhance after second myocardial infarction attack. The Cr and Mn concentration was inversely associated with the risk of myocardial infarction attacks in both genders. These results add to an increasing body of evidence that, Cr and Mn are importance for cardiovascular health.

Preventive Effects of Selenium Yeast, Chromium Picolinate, Zinc Sulfate and their Combination on Oxidative Stress, Inflammation, Impaired Angiogenesis and Atherogenesis in Myocardial Infarction in Rats

“…In addition, the possible angiogenic mechanisms operating via increasing cardiac VEGF and serum NO were also investigated. In consistent with previous reports (14,18,19) our results ( Table 1) revealed significantly decreased serum levels of Se, Cr and Zn in ISO control group. This elements dyshemostasis plays a critical role in the pathogenesis of MI (20) which strongly suggests the beneficial effects of trace elements supplementation on the outcome of MI.…”

“…Reduced circulating levels of the trace elements; selenium (12)(13)(14), zinc (15)(16)(17)(18) and chromium (19) are found in patients and experimental models of MI. The decrease in the serum levels of zinc and selenium was observed in patients with higher levels of cardiac biomarkers, which implies that trace element levels are related to the degree of myocardial damage and may play a role in the pathogenesis of ischemic heart disease (13,18).…”

Evaluation of the content and bioaccessibility of iron, zinc, calcium and magnesium from groats, rice, leguminous grains and nuts

“…Since cereals and leguminous grain products are staple foods for most of populations worldwide, they are also major sources of essential minerals, depending on a particular plant variety, agricultural practices, soil and climatic conditions, as well as technological and culinary practices applied (Afridi et al 2010). The total contents of Fe, Zn, Ca and Mg in a given food product are not the only criteria determining its nutritional quality, as it also depends on their bioavailability from that product.…”

The Association between Mineral and Trace Element Concentrations in Hair and the 10-Year Risk of Atherosclerotic Cardiovascular Disease in Healthy Community-Dwelling Elderly Individuals

“…These findings suggest that increased aldosterone levels and activity in high-risk ASCVD patients may lead to an increase in intracellular Na uptake via ENaC in hair follicles, resulting in higher Na concentrations in hair. Similarly, Na levels were reported to be higher in the hair of ischemic stroke patients [33] and in blood and scalp hair samples of patients with myocardial infarction [34].…”