Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Mastren, Tara; Radchenko, Valery; Engle, Jonathan W.; Weidner, John W.; Owens, Allison; Wyant, Lance; Copping, Roy; Brugh, Mark; Nortier, F.M.; Birnbaum, Eva R.; John, Kevin D.; Fassbender, Michael E.

doi:10.1016/j.aca.2017.10.020

Cited by 24 publications

(25 citation statements)

References 33 publications

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“…Among the large plethora of β – -emitting metal radionuclides that have been proposed for TRT so far, silver-111 ( 111 Ag, t 1/2 7.47 days) is regarded to be promising due to its medium-energy β – particles (β max 1.04 MeV) and its two useful low energy γ-rays ( E γ 245.4 keV [ I γ 1.24%]; E γ 342.1 keV, [ I γ 6.7%]) suitable for single photon emission computed tomography (SPECT) imaging. − An additional positive feature is that the β + -emitters silver-103g ( t 1/2 65.7 min, β + 27%, EC 73%) or silver-104g ( t 1/2 69.2 min, β + 15%, EC 85%) could be used as positron emission tomography (PET) imaging analogues. , A metal ion that is both diagnostic and therapeutic (i.e., theranostic) allows a more reliable evaluation of the absorbed dose and, consequently, a better indication of the therapeutic activity necessary for the treatment with respect to two different elements, one for diagnosis and one for therapy . Furthermore, the relatively long half-time of 111 Ag matches well with the biological half-lives of antibodies (2–3 weeks), making this isotope interesting for use in radioimmunotherapy. , …”

Section: Introductionmentioning

confidence: 99%

Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals

et al. 2020

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With a half-life of 7.45 days, silver-111 (β max 1.04 MeV, E γ 245.4 keV [ I γ 1.24%], E γ 342.1 keV [ I γ 6.7%]) is a promising candidate for targeted cancer therapy with β – emitters as well as for associated SPECT imaging. For its clinical use, the development of suitable ligands that form sufficiently stable Ag + -complexes in vivo is required. In this work, the following sulfur-containing derivatives of tetraazacyclododecane (cyclen) have been considered as potential chelators for silver-111: 1,4,7,10-tetrakis(2-(methylsulfanyl)ethyl)-1,4,7,10-tetraazacyclododecane (DO4S), (2S,5S,8S,11S)-2,5,8,11-tetramethyl-1,4,7,10-tetrakis(2-(methylsulfanyl)ethyl)-1,4,7,10-tetraazacyclododecane (DO4S4Me), 1,4,7-tris(2-(methylsulfanyl)ethyl)-1,4,7,10-tetraazacyclododecane (DO3S), 1,4,7-tris(2-(methylsulfanyl)ethyl)-10-acetamido-1,4,7,10-tetraazacyclododecane (DO3SAm), and 1,7-bis(2-(methylsulfanyl)ethyl)-4,10,diacetic acid-1,4,7,10-tetraazacyclododecane (DO2A2S). Natural Ag + was used in pH/Ag-potentiometric and UV–vis spectrophotometric studies to determine the metal speciation existing in aqueous NaNO 3 0.15 M at 25 °C and the equilibrium constants of the complexes, whereas NMR and DFT calculations gave structural insights. Overall results indicated that sulfide pendant arms coordinate Ag + allowing the formation of very stable complexes, both at acidic and physiological pH. Furthermore, radiolabeling, stability in saline phosphate buffer, and metal-competition experiments using the two ligands forming the strongest complexes, DO4S and DO4S4Me, were carried out with [ 111 Ag]Ag + and promising results were obtained.

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Section: Introductionmentioning

confidence: 99%

Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals

et al. 2020

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“…For instance, the mineral monazite, the main mineral source of Th 4+ , is also associated with lanthanum, cerium, samarium, yttrium, and other elements [ 6 , 7 ]. Recently, the scientific importance and commercial value of Th has received much research attention because of its extensive use in various areas, including optics, radios, aeronautics, aerospace, metallurgy, chemical and nuclear industries, materials science [ 8 – 12 ], and nuclear medicine. In particular, Th is considered a promising (neutron irradiation) fertile material for producing nuclear fuel because it is associated with fewer radioactive fission products and produces lower quantities of highly radiotoxic actinides [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf

Huang

Chen

et al. 2018

PLoS ONE

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Low–cost biosorbents (ginkgo leaf, osmanthus leaf, banyan leaf, magnolia leaf, holly leaf, walnut shell, and grapefruit peel) were evaluated in the simultaneous removal of La3+, Ce3+, Pr3+, Nd3+, Sm3+, Eu3+, Gd3+, Yb3+, Lu3+, UO22+, Th4+, Y3+, Co2+, Zn2+, Ni2+, and Sr2+ from aqueous solutions. In single metal systems, all adsorbents exhibited good to excellent adsorption capacities toward lanthanides and actinides. In a simulated multicomponent mixed solution study, higher selectivity and efficiency were observed for Th4+ over other metal cations, with ginkgo leaves providing the highest adsorptivity (81.2%) among the seven biosorbents. Through optimization studies, the selectivity of Th4+ biosorption on ginkgo leaf was found to be highly pH–dependent, with optimum Th4+ removal observed at pH 4. Th4+ adsorption was found to proceed rapidly with an equilibrium time of 120 min and conform to pseudo–second–order kinetics. The Langmuir isotherm model best described Th4+ biosorption, with a maximum monolayer adsorption capacity of 103.8 mg g–1. Thermodynamic calculations indicated that Th4+ biosorption was spontaneous and endothermic. Furthermore, the physical and chemical properties of the adsorbent were determined by scanning electron microscopy, Brunauer–Emmett–Teller, X-ray powder diffraction, and Fourier transform infrared analysis. The biosorption of Th from a real sample (monazite mineral) was studied and an efficiency of 90.4% was achieved from nitric acid at pH 4 using ginkgo leaves.

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“…Separation of Ag-111 from one of the waste streams of Ac-225 processing could be initiated, but introducing a separation step would be critical to remove ingrown daughters of short-lived Ag isotopes. Purification methods have been developed that could purify the Ag-111 from the Ac-225 waste streams [16]. Long-lived impurities (Ag-105, Ag-110m) could hinder the medical use of Ag-111 purified from Ac-225 waste streams.…”

Section: Discussionmentioning

confidence: 99%

Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium

et al. 2019

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During the purification of radioisotopes, decay periods or time dependent purification steps may be required to achieve a certain level of radiopurity in the final product. Actinum-225 (Ac-225), Silver-111 (Ag-111), Astatine-211 (At-211), Ruthenium-105 (Ru-105), and Rhodium-105 (Rh-105) are produced in a high energy proton irradiated thorium target. Experimentally measured cross sections, along with MCNP6-generated cross sections, were used to determine the quantities of Ac-225, Ag-111, At-211, Ru-105, Rh-105, and other co-produced radioactive impurities produced in a proton irradiated thorium target at Brookhaven Linac Isotope Producer (BLIP). Ac-225 and Ag-111 can be produced with high radiopurity by the proton irradiation of a thorium target at BLIP.

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Chromatographic separation of the theranostic radionuclide 111Ag from a proton irradiated thorium matrix

Cited by 24 publications

References 33 publications

Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals

Highly Stable Silver(I) Complexes with Cyclen-Based Ligands Bearing Sulfide Arms: A Step Toward Silver-111 Labeled Radiopharmaceuticals

Selective biosorption of thorium (IV) from aqueous solutions by ginkgo leaf

Defining Processing Times for Accelerator Produced 225Ac and Other Isotopes from Proton Irradiated Thorium

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