Chromatographic separation and detection methods of Aloe arborescens Miller constituents: A systematic review

Nazeam, Jilan A.; Gad, Haidy A.; El-Hefnawy, Hala M; Singab, Abdel Nasser B.

doi:10.1016/j.jchromb.2017.04.044

Cited by 25 publications

(12 citation statements)

References 41 publications

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“…Therefore, interest in the potential anticancer activity of herbal compounds is gaining attention (23). Approximately 20 chemical constituents have been reported as the major biologically active components within the extracts of Aloe species (24)(25)(26)(27). These phytochemicals include anthraquinones (aloe-emodin, emodin and chrysophanol), anthranols (aloin A, aloin B, aloinoside A, aloinoside B and aloesaponol), chromones (aloesin and aloesone), coumarins (esculetin and umbelliferone), pyrans and pyrones (aloenin), flavonoids (isovitexin), naphthalene derivatives (plicataloside) and polysaccharides (acemannan) (24)(25)(26)(27).…”

Section: Molecular Mechanisms and Associated Cell Signalling Pathways Underlying The Anticancer Properties Of Phytochemical Compounds Fromentioning

confidence: 99%

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

2021

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Naturally occurring components from various species of Aloe have been used as traditional folk medicine since the ancient times. Over the last few decades, the therapeutic effects of extracts and phytochemical compounds obtained from Aloe vera have been proven in preclinical and clinical studies. Recently, compounds from other Aloe species apart from Aloe vera have been investigated for the treatment of different diseases, with a particular focus on cancer. In the present review, the effects of phytochemical compounds obtained from different Aloe species are discussed, with a specific focus on the effects on cell signalling in cancer and normal cells, and their selectivity and efficacy. This information will be useful for the application of Aloe-derived compounds as therapeutic agents, either alone or in combination with other standard drugs for cancer treatment. Contents 1. Introduction 2. Cell death initiation by the phytochemical compounds of Aloe 3. Anticancer selectivity 4. Cell cycle regulation 5. Cell signalling 6. Angiogenesis 7. Migration and invasion 8. Inflammation and immunomodulation (TNF-α/NF-κB pathway) 9. Recommendations for future applications 10. Conclusions

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Section: Molecular Mechanisms and Associated Cell Signalling Pathways Underlying The Anticancer Properties Of Phytochemical Compounds Fromentioning

confidence: 99%

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

2021

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“…The content of the active ingredient in the aloe lyophilized powder was determined by measuring the Oacetyl content by spectrophotometry and preparing a standard curve, as described previously [20,21].…”

Section: Determination Of the Active Ingredient In Aloe Freeze-dried Powdermentioning

confidence: 99%

WITHDRAWN: Effects of Persimmon Tannin-Aloe Vera Composite on Cytotoxic Activities, and Radioprotection Against X-rays Irradiated in HepG2 and L02 Cells

2021

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“…The characteristic components of the red sap are 1,8-dihydroxyanthraquinones and their glycosides, mainly aloe-emodin and aloin, whose structures are reported in Figure 1. Further, a large amount of acemannan is present in the inner gel of the leaves [4]. The Aloe genus is known for its traditional use, but the isolated compounds, mainly aloe-emodin, have also been studied as potential conventional drugs.…”

Section: Introductionmentioning

confidence: 99%

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts

et al. 2019

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Aloe arborescens is a relevant species largely used in traditional medicine of several countries. In particular, the decoction of leaves is prepared for various medicinal purposes including antidiabetic care. The aim of this research was the study of the antiglycation activity of two A. arborescens leaf extracts and isolated compounds: aloin and aloe-emodin. These phytoconstituents were quantitatively assessed in methanolic and hydroalcoholic extracts using high performance liquid chromatography (HPLC) analysis. In addition, the total phenolic and flavonoid contents were detected. In order to study their potential use in diabetic conditions, the antiglycation and antiradical properties of the two extracts and aloin and aloe-emodin were investigated by means of bovine serum albumin (BSA) and 1,1-diphenyl-2-picryl-hydrazil (DPPH) assays; further, their cytotoxicity in HT-29 human colon adenocarcinoma cells was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay. Furthermore, the ability of aloin and aloe-emodin to permeate the cellular membranes of HT-29 cells was determined in order to estimate their potential in vivo absorption. This assessment indicated that aloe-emodin can substantially pass through cell membranes (~20%), whereas aloin did not permeate into HT-29 cells. Overall, the data show that both the methanolic and the hydroalcoholic A. arborescens extracts determine significant inhibition of glycation and free-radical persistence, without any cytotoxic activity. The data also show that the antiglycation and the antiradical activities of aloin and aloe-emodin are lower than those of the two extracts. In relation to the permeability study, only aloe-emodin is able to cross HT-29 cellular membranes, showing the attitude to pass through the intestinal layer. Overall, the present data surely support the traditional use of A. arborescens leaf extracts against hyperglycemic conditions, while aloin and aloe-emodin as potential drugs need further study.

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Chromatographic separation and detection methods of Aloe arborescens Miller constituents: A systematic review

Cited by 25 publications

References 41 publications

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

Molecular mechanisms and associated cell signalling pathways underlying the anticancer properties of phytochemical compounds from Aloe species (Review)

WITHDRAWN: Effects of Persimmon Tannin-Aloe Vera Composite on Cytotoxic Activities, and Radioprotection Against X-rays Irradiated in HepG2 and L02 Cells

Antiglycation Activity and HT-29 Cellular Uptake of Aloe-Emodin, Aloin, and Aloe arborescens Leaf Extracts

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