Chromatographic Separation and Assay of Morphine in Injectables

Holcomb, Ira J.; Luers, R.B.; Fusari, Salvatore A.

doi:10.1002/jps.2600620927

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Pharmaceutical Analysis1

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1974

2004

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Cited by 5 publications

(1 citation statement)

References 16 publications

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“…Ion exchange prior to measurement was used in the determination of dextoamphetamine sulfate and amobarbital (61) and nitrogenous drugs (243). Morphine in injectables was measured after separation using diatomaceous earth (125).…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

Ultraviolet spectrometry

Hummel¹,

Kaufman²

1974

Anal. Chem.

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Section: Pharmaceutical Analysismentioning

confidence: 99%

Ultraviolet spectrometry

Hummel¹,

Kaufman²

1974

Anal. Chem.

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Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

Garrido¹,

Delerue–Matos²,

Borges

et al. 2004

Electroanalysis

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A detailed study of the electrochemical oxidative behavior of morphine in aqueous solution is reported. Through the synthesis of several metabolites and derivatives, pseudomorphine, morphine N-oxide, normorphine, dihydromorphine and 2-(N,N-dimethylaminomethyl)morphine, and their voltammetric study it was possible to identify the oxidation peaks for morphine. The anodic waves are related with the oxidation of phenolic and tertiary amine groups. It is also possible to verify that a poorly defined peak observable during morphine oxidation is not a consequence of further oxidation of pseudomorphine but due to formation of a dimer during phenolic group oxidation. The results obtained and especially those regarding the formation of a new polymer based on a CÀO coupling could be useful for clarifying the discoloration phenomenon occurring during storage of morphine solutions as well as leading to a better understanding of its oxidative metabolic pathways.

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Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites

Garrido¹,

Delerue–Matos²,

Borges

et al. 2004

Electroanalysis

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The oxidation of codeine on glassy carbon electrodes has been studied in detail using differential pulse voltammetry. The results obtained using a glassy carbon electrode clearly show a much more complex oxidation mechanism than that previously reported when platinum and gold electrodes were used. To clarify the codeine oxidative profile, several metabolites and analogues of this alkaloid, codeine N-oxide, norcodeine, dihydrocodeine, acetylcodeine and 6-chlorodesoxycodeine, were synthesized and studied. It was deduced that the anodic waves observed in codeine oxidation are related to the presence of methoxy, hydroxy and tertiary amine groups. Due to the similarity of potentials at which these oxidative processes take place, at some pHs an overlap of peaks occurs and only one anodic wave is observed.

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Chromatographic Separation and Assay of Morphine in Injectables

Cited by 5 publications

References 16 publications

Ultraviolet spectrometry

Ultraviolet spectrometry

Voltammetric Oxidation of Drugs of Abuse I. Morphine and Metabolites

Voltammetric Oxidation of Drugs of Abuse II. Codeine and Metabolites

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