Chromatographic methods for the determination of active substances and characterization of their impurities in pesticide formulations

Płonka, Marlena; Walorczyk, Stanisław; Miszczyk, M.

doi:10.1016/j.trac.2016.03.011

Cited by 39 publications

(17 citation statements)

References 48 publications

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“…Based on the difference between the partition coefficients of the analytical substances between the stationary and the mobile phases, chromatography can separate the analytical substance precisely, and then convert the concentration of the analyte into an electrical signal which can easily measure and send it to the record for recording (Weng et al, 2020). Tandem mass spectrometry (MS/MS) can be operated in a selective reaction monitoring mode (SRM) to achieve high sensitivity and selectivity of pesticide residues detection, and it can also provide structural information from molecular masses and fragmentation pattern (Plonka, Walorczyk, & Miszczyk, 2016). Wong et al used solid-phase extraction to extract pesticides from wines, and then, gas chromatography-mass spectrometric detection was used to detect 153 pesticides in wines.…”

Section: Conventional Identification Methods Of Organophosphorus Pestmentioning

confidence: 99%

Pesticide residues identification by impedance time‐sequence spectrum of enzyme inhibition on multilayer paper‐based microfluidic chip

Yang

et al. 2020

J Food Process Engineering

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Different organophosphorus pesticides (OPs) normally vary in the level of toxicity to human health, but common electrochemical identification methods usually require complex electrode fabrication processes and high detection cost. To overcome these problems, a pesticide residues identification method based on multilayer paper-based microfluidic chip was proposed. The microfluidic chip integrates the enzyme inhibition and a label-free screen-printed carbon electrode (SPCE). Three different pesticides were selected as study objects, respectively, avermectin, phoxim, dimethoate. This chip realizes on-chip identification via analyzing impedance time-sequence spectrum data aroused by the enzyme inhibition during the 15 min period. A classification model based on principal component analysis (PCA) and support vector machines (SVMs) was established to evaluate these data. Furthermore, the real-world sample (lettuce) was tested to verify the feasibility of the proposed detection method. The results showed that the classification accuracy was achieved around 93% in multiple experiments. Therefore, the method has good stability and specificity in rapid identification of different pesticides. Practical Applications Identification of pesticide types is essential to human health, for this, impedance time-sequence spectrum data aroused by the enzyme inhibition during the 15 min period was used to establish a classification model to identity different types of pesticides. In this article, multilayer paper-based microfluidic chip and a label-free screenprinted carbon electrode (SPCE) was proposed without complicated operation steps and expensive cost, which provide a basis for establishment of the rapid pesticide discriminator.

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Section: Conventional Identification Methods Of Organophosphorus Pestmentioning

confidence: 99%

Pesticide residues identification by impedance time‐sequence spectrum of enzyme inhibition on multilayer paper‐based microfluidic chip

Yang

et al. 2020

J Food Process Engineering

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“…HPLC combined with other techniques such as mass spectrometry allow reliable determination of the highest number of active substances contained in plant protection products, and their impurities, in the shortest possible time, followed by practical implementation of these developed methods for routine control of the products currently on the market. 49…”

Section: Chromatographic Methods For the Determination Of Active Substances And Characterization Of Their Impurities In Pesticide Formulamentioning

confidence: 99%

A review of HPLC technique covering its pharmaceutical, environmental, forensic, clinical and other applications

Chawla¹,

Chaudhary²

2019

IJPCA

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HPLC is an analytical technique widely used for identification, separation, detection and quantification of various drugs and its related degradants. Appropriate mobile phase, stationary phase, column, column size, temperature, wavelength and gradient selection is important for the suitable compatibility and stability of drug as well as impurities and degradants. Most of the drugs as well as other compounds can be analyzed by HPLC method because of the several advantages like rapidity, specificity, accuracy, precision and ease of automation in this method. This article has been prepared with an aim to review different aspects of HPLC, such as principle, types, mode of separation, characteristics, instrumentation, important parameters and various applications of HPLC in different fields.

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“…Thus, they can be adopted to identify substandard products. Possible issues include 1) out-of-specification content of active pharmaceutical ingredient (API), 24,25 2) significant dissolution delay, 24 3) contamination with toxic substances, 26,27 and 4) lack of sterility. 28,29 These points can be checked by means of assay, content uniformity testing, measurements of dissolution properties and impurities, and microbial tests.…”

Section: Introductionmentioning

confidence: 99%

Survey to Identify Substandard and Falsified Tablets in Several Asian Countries with Pharmacopeial Quality Control Tests and Principal Component Analysis of Handheld Raman Spectroscopy

Kakio

Nagase

Takaoka

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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The World Health Organization has warned that substandard and falsified medical products (SFs) can harm patients and fail to treat the diseases for which they were intended, and they affect every region of the world, leading to loss of confidence in medicines, health-care providers, and health systems. Therefore, development of analytical procedures to detect SFs is extremely important. In this study, we investigated the quality of pharmaceutical tablets containing the antihypertensive candesartan cilexetil, collected in China, Indonesia, Japan, and Myanmar, using the Japanese pharmacopeial analytical procedures for quality control, together with principal component analysis (PCA) of Raman spectrum obtained with handheld Raman spectrometer. Some samples showed delayed dissolution and failed to meet the pharmacopeial specification, whereas others failed the assay test. These products appeared to be substandard. Principal component analysis showed that all Raman spectra could be explained in terms of two components: the amount of the active pharmaceutical ingredient and the kinds of excipients. Principal component analysis score plot indicated one substandard, and the falsified tablets have similar principal components in Raman spectra, in contrast to authentic products. The locations of samples within the PCA score plot varied according to the source country, suggesting that manufacturers in different countries use different excipients. Our results indicate that the handheld Raman device will be useful for detection of SFs in the field. Principal component analysis of that Raman data clarify the difference in chemical properties between good quality products and SFs that circulate in the Asian market.

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Chromatographic methods for the determination of active substances and characterization of their impurities in pesticide formulations

Cited by 39 publications

References 48 publications

Pesticide residues identification by impedance time‐sequence spectrum of enzyme inhibition on multilayer paper‐based microfluidic chip

Pesticide residues identification by impedance time‐sequence spectrum of enzyme inhibition on multilayer paper‐based microfluidic chip

A review of HPLC technique covering its pharmaceutical, environmental, forensic, clinical and other applications

Survey to Identify Substandard and Falsified Tablets in Several Asian Countries with Pharmacopeial Quality Control Tests and Principal Component Analysis of Handheld Raman Spectroscopy

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