Chromatographic finger print analysis of steroids in Aerva lanata L by HPTLC technique

Mariswamy, Yamunadevi; Wesely, Edward Gnaraj; Johnson, M

doi:10.1016/s2221-1691(11)60094-4

Cited by 57 publications

(19 citation statements)

References 11 publications

(10 reference statements)

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“…In the last few years, gas chromatography-mass spectrometry (GC-MS) has become firmly established as a key technological platform for secondary metabolite profiling in both plant and non-plant species 15,16,17 . Gas-Chromatography-Mass Spectrometry (GC-MS) is a helpful technique for reliable profiling of secondary metabolites [18][19] . GC-MS can also be used in airport security to detect substances in luggage or on human beings.…”

Section: Issn: 2250-1177mentioning

confidence: 99%

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

Sasikala¹,

Ganesan²,

Jayaseelan³

et al. 2019

J. Drug Delivery Ther.

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Objective:To identify the phytochemical constituents present in ethanolic leaves extract of Taraxacum officinale (T. o) and to elucidate the bioactive compounds. Methods: The fresh leaves of T. officinale (1000g) were shade dried at room temperature for 30 days and the dried leaves were made into a fine powder. The ethanolic leaves extract obtained was dried with help of desiccator and rotatory evaporator. The dried samples tested for phytochemical analysis and bioactive compounds profiling through GC-MS analysis. Results: The phytochemical screening studies showed presence of alkaloids, flavonoids, phenol, cardiac glycosides and anthraquinones. in the leaves extract of T. officinale. GC-MS analysis showed 10 essential bioactive compounds and it revealed the presence of significant anticancer, Antimicrobial and antidiabetic compounds. Conclusions: The ethanol extract of T. o possess the most important phytochemical compounds and it has various medicinal properties to cure dangerous diseases and disorders.

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Section: Issn: 2250-1177mentioning

confidence: 99%

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

Sasikala¹,

Ganesan²,

Jayaseelan³

et al. 2019

J. Drug Delivery Ther.

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“…A large number of plants produce secondary metabolites such as alkaloids, flavonoids, terpenes, steroids that are used in pharmaceuticals, cosmetics and pesticide industries [16]. Flavonoids have been reported to possess many useful properties, including anti-inflammatory, oestrogenic, enzyme inhibition, antimicrobial, anti-allergic, antioxidant, vascular and cytotoxic antitumor activity [17,18].…”

Section: Resultsmentioning

confidence: 99%

A Study on the Bioactive Compounds Present in Leaves of Dichrostachys Cinerea

A¹

2016

gctl

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Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug because of the unmatched availability of chemical diversity. Due to an increasing demand for chemical diversity, seeking therapeutic drugs from natural products interest particularly in edible plants has grown throughout the world. Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. The focus of this paper is on the analytical methodologies, which include the extraction, isolation and characterization of active components in leaves of Dichrostachys cinerea. The analysis of bioactive compounds present in the plant extracts involve the application of common phytochemical screening tests, physicochemical tests, chromatographic techniques such as HPLC and TLC were discussed.

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“…A biomarker on the other hand is a group of chemical compounds which are not unique for that plant material but also correlates with biological efficacy. So, the need arises to lay standards by which the right material could be selected and incorporated into the formulation 11 . Medicinal plants are reported to possess a wide range of properties including anti-carcinogenic, anti-inflammatory, antioxidant, antitumor, antimicrobial, immune modulatory, anti-helminthic, antiviral, and antibiotic activities 12,13 .…”

Section: Anti-hiv Activity Of Isolated Alkaloid Compound From E Albamentioning

confidence: 99%

In Vitro Hiv-1 Reverse Transcriptase Inhibition by Alkaloids Isolated From Leaves of Eclipta Alba

Gurrapu¹,

Mamidala²

2018

Int. Res. J. Pharm.

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The high price of the highly active anti-retroviral therapy (HAART) programme has encumbered its distribution to over 90% of the HIV/AIDS inhabitants in the world. This reality has instantly called for the essential to progress low-cost alternate anti-HIV/AIDS treatment. The objective of this study is to isolate alkaloid from E. alba leaves for their activities against HIV-1 reverse transcriptase. Collected leaves of E. alba were extracted with altered solvents and the purity of isolated alkaloids was checked by TLC and qualitative phytochemical analysis were done. Peripheral Blood Mononuclear Cells (PBMCs) isolated from healthy donors by ficoll-hypaque density gradient centrifugation method. Cell viability test was achieved on isolated phytochemicals by MTT assay against PBMC and HIV-1 RT inhibition activity was determined by HIV-1 Reverse Transcriptase (p66) Capture ELISA. In the HIV-1 reverse transcriptase assay, the isolated alkaloid showed 89% of HIV-1 reverse transcription with IC50 of 5 µg/ml. MTT assay revealed that, the alkaloid isolated from E. alba had no cytotoxic activity (IC50 values higher than 100 µg/ml). Characterization of important biologically-active alkaloid from E. alba plant will certainly be supportive in defending and handling various viral diseases in human beings. The results of the present study sustenance the medicinal usage of the alkaloid isolated from the leaves of E. alba can be used as antiviral agents and can be subjected to characterize the therapeutic drugs and undergo further pharmacological screening that can be used as sources for new drugs.

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Chromatographic finger print analysis of steroids in Aerva lanata L by HPTLC technique

Cited by 57 publications

References 11 publications

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

Phytochemicals and GC–MS analysis of bioactive compounds present in ethanolic leaves extract of Taraxacum officinale (L).

A Study on the Bioactive Compounds Present in Leaves of Dichrostachys Cinerea

In Vitro Hiv-1 Reverse Transcriptase Inhibition by Alkaloids Isolated From Leaves of Eclipta Alba

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