Chromatographic behaviour of alkyl-bonded phases: Separation of barbiturates and pyrazolones on precoated plates

Marichy, M.; Gonnet, C.; Zlatanov, L.

doi:10.1007/bf02311684

Cited by 6 publications

(1 citation statement)

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“…Phenyl Methyl Pyrazolone has been determined by titration with perchloric acid (CTFA, 1990); high-performance liquid chromatography (HPLC) (Danhof et al, 1979;DeVriesetal., 1984;Eichelbaum etal., 1981;Kahn etal., 1981;L'Oreal, 1985;Mikati et al, 1988;Moncreiff, 1986;Nakagawa et al, 1982;Teunissen et al, 1983); thin layer chromatography (Marichy et al, 1986); a gas chromatography chemical ionization mass spectrometric procedure (Tang et al, 1982); a gas chromatographic mass spectrometric procedure (Baty and Price Evans, 1973;Hignite et al, 1978;Murray, 1980); gas spectrometry (Hignite et al, 1978;lnaba and Fischer, 1980); mass spectrometry (Baty and Price Evans, 1973); and selective acid hydrolysis (Bottcher et al, 1984). Hawley, 1971Estrin et al, 1982Weast, 1982Crasselli, 1973Weast, 1982Crasselli, 1973Weast, 1982Crasselli, 1973Weast, 1982Hawley, 1971Weast, 1982Weast, 1982Crasselli, 1973 Grasselli.…”

Section: Methodsmentioning

confidence: 99%

Final Report on the Safety Assessment of Phenyl Methyl Pyrazolone

1992

Journal of the American College of Toxicology

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Phenyl Methyl Pyrazolone (PMP) is a heterocyclic amine that is used in hair colorants. The phenylhydrazine content in PMP is below the limit of detection. Phenyl Methyl Pyrazolone was slightly toxic to rats, with an oral LD,, of 3.5 g/kg. Feeding rats and mice with PMP-treated feed for 7 weeks was uneventful. A compound containing 500 mg/kg of PMP was, at most, a mild ocular irritant. Phenyl Methyl Pyrazolone was slightly irritating to rabbit skin when tested under occlusive patches. It did not produce a sensitization reaction in guinea pigs. Phenyl Methyl Pyrazolone was nonmutagenic in two assays and noncarcinogenic in oral feeding studies. On the basis of the available data presented in this report, it is concluded that Phenyl Methyl Pyrazolone is safe for use as a cosmetic ingredient in the present practices of use and concentration.Phenyl Methyl Pyrazolone is also known as 3-methyl-1 -phenyl-5-pyrazolone; 1 -phenyl-3-methylpyrazolone-5; 1 -phenyI-3-methyl-5-pyrazolone; 2-pyrazol in-5-one, 47s

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