Chromatographic and Spectral Analysis of Polycyclic Aromatic Hydrocarbons in the Air and Water Environments

Katz, Michael; Sakuma, Takeo; Tosine, H.

doi:10.1007/978-1-4684-3617-4_8

Cited by 7 publications

(9 citation statements)

References 9 publications

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“…In addition, PAHs can be chemically modified in the atmosphere upon exposure to ultraviolet light. This photomodification can produce PAH-diol and quinone products ( , ) that can be more toxic to fish ( , ) and plants ( , ) than the parent PAH.…”

Section: Resultsmentioning

confidence: 99%

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays

Clemons

Allan

Marvin

et al. 1998

Environ. Sci. Technol.

185

134

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Polar and nonpolar fractions prepared from an organic extract of inhalable air particulate material collected from an urban location in downtown Toronto, Ontario, Canada, were examined for estrogen and Ah receptor-mediated activities using in vitro gene expression assays. The presence of estrogenic activity was determined using MCF-7 human breast cancer cells transiently transfected with a Gal4-human estrogen receptor chimera and a Gal4-regulated luciferase reporter gene. 2,3,7,8-Tetracholordibenzo-p-dioxin (TCDD)-like activity was detected using Hepa 1c1c7 cells transiently transfected with a CYP1A1-regulated reporter gene (pGudLuc 1.1). Significant estrogenic and TCDD-like activity was detected in the crude extract and in the nonpolar fractions. Results from the analyses of nine environmentally prevalent polyaromatic hydrocarbons (PAH) indicated that PAH might be significant contributors to the observed activity. Surprisingly, three PAH, namely benzo[a]pyrene, chrysene, and benz[a]anthracene, were found to substantially induce in vitro estrogenic and TCDD-like activities that were mediated by the estrogen and Ah receptors, respectively. Benzo[k]fluoranthene, dibenz[a,h]anthracene, and anthracene also exhibited significant in vitro TCDD-like activity. These results demonstrate the utility of in vitro gene expression assays to identify the presence of potential endocrine disruptors within complex mixtures.

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Section: Resultsmentioning

confidence: 99%

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays

Clemons

Allan

Marvin

et al. 1998

Environ. Sci. Technol.

185

134

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“…Despite the great interest in the atmospheric fate and chemical transformations of polycyclic aromatic hydro-carbons (PAH) associated with airborne particles (1-4), there have been only a few papers describing the kinetics of the reaction between gaseous ozone (03) and surfaceadsorbed PAH (5)(6)(7)(8)(9). Furthermore, these papers reported very different estimates for the half-life of PAH exposed tó 03.…”

Section: Introductionmentioning

confidence: 99%

Fluorescence spectroscopic study of reactions between gaseous ozone and surface-adsorbed polycyclic aromatic hydrocarbons

Wu¹,

Salmeen²,

Niki³

1984

Environ. Sci. Technol.

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“…Evidence of tumorigenic potential in humans has come from epidemiological studies of workers exposed to high levels of these compounds (1)(2)(3)(4). 1 Presented at the Symposium on Atmospheric Chemistry, 182nd National Meeting of the Americal Chemical Society, August [23][24][25][26][27][28]1981, New York; Abstr. PHYS 184.…”

Section: Introductionmentioning

confidence: 99%

A photoreactor for investigations of the degradation of particle-bound polycyclic aromatic hydrocarbons under simulated atmospheric conditions

Daisey¹,

Lewandowski²,

Zorz³

1982

Environ. Sci. Technol.

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The rate equation for the oxidation of thiosulfate by molecular oxygen in an autoclave can be written as follows:-d[S2032~]/df = MSAMtOH-V-HPo,)1•66 (16) From the observed rates, after subtraction of induction periods, the average value of the rate constant k, based on six calculations, was 1.66 X IO^M^^P q^"1•66 s-1. The range was (1.3-2.0) X 10"6, standard deviation was 0.32 X 10""6, and the relative standard deviation was 19%.

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Chromatographic and Spectral Analysis of Polycyclic Aromatic Hydrocarbons in the Air and Water Environments

Cited by 7 publications

References 9 publications

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays

Fluorescence spectroscopic study of reactions between gaseous ozone and surface-adsorbed polycyclic aromatic hydrocarbons

A photoreactor for investigations of the degradation of particle-bound polycyclic aromatic hydrocarbons under simulated atmospheric conditions

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Chromatographic and Spectral Analysis of Polycyclic Aromatic Hydrocarbons in the Air and Water Environments

Cited by 7 publications

References 9 publications

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM10 Air Particulate Material Using in Vitro Gene Expression Assays

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM10 Air Particulate Material Using in Vitro Gene Expression Assays

Fluorescence spectroscopic study of reactions between gaseous ozone and surface-adsorbed polycyclic aromatic hydrocarbons

A photoreactor for investigations of the degradation of particle-bound polycyclic aromatic hydrocarbons under simulated atmospheric conditions

Contact Info

Product

Resources

About

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays

Evidence of Estrogen- and TCDD-Like Activities in Crude and Fractionated Extracts of PM₁₀ Air Particulate Material Using in Vitro Gene Expression Assays