Chromatographic and electrophoretic determination of thioamides based on thiazole, 1,3,4-thiadiazole, 1,2,4-triazole, and tetrazole

Chernov’yants, M. S.; Aleshina, N. V.; Бурыкин, И. В.

doi:10.1134/s1061934811010023

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The most commonly used analytical techniques for the determination and quantification of DMcT are capillary zone electrophoresis (CZE) and high performance liquid chromatography (HPLC) with UV detection. 7,8 These methods require expensive and non-portable instrumentation, trained personnel, sophisticated sample preparation, and suffer from numerous chemical interferences. The electrochemical techniques have some advantages like simplicity, fast response, wide linear dynamic range, ease of miniaturization, high sensitivity and low cost compared to other methods.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex

Pazalja

2021

Kem. ind. (Online)

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The thiol compound 2,5-dimercapto-1,3,4-thiadiazole is a potential cathode material. The redox reactions of the mentioned thiol compound are slow at room temperature but can be enhanced using electron transfer mediators. The electrochemical oxidation of 2,5-dimercapto-1,3,4-thiadiazole on the surface of carbon electrodes modified with Ruthenium(III) Schiff base complex was studied by voltammetric methods and amperometric flow injection analysis. The electrocatalytic properties of Ruthenium(III) Schiff base complex on glassy carbon and screen printed carbon electrodes are enhanced by the addition of multi-walled carbon nanotubes and Nafion. Voltammetric studies showed that anodic oxidation of DMcT on a modified glassy carbon electrode occurs at a potential of +0.28 V vs. Ag/AgCl in Britton-Robinson buffer (pH 6.50). Flow injection amperometric measurements were performed at +0.20 V vs. Ag/AgCl in Britton-Robinson buffer solutions pH 6.50 at a 0.40 cm3 min–1 flow rate. The results of amperometric measurements for modified screen printed and glassy carbon electrodes showed that the screen printed electrode had a lower value of detection limit (0.38 mg dm–3) and quantification (1.28 mg dm–3), and a linear dynamic range from 1 to 500 mg dm–3 of 2,5-dimercapto-1,3,4-thiadiazole. Modified glassy carbon electrode provided a linear dynamic range up to 750 mg dm–3 of 2,5-dimercapto-1,3,4-thiadiazole with a detection limit of 3.90 mg dm–3 and quantification of 13.20 mg dm–3.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex

Pazalja

2021

Kem. ind. (Online)

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“…The purpose of this study was to therefore develop, optimize, and validate a new method for quantifying ClABT using HPLC separation and UV detection given that there are no other methods described in the scientific literature for its specific measurement in biological media. Procedures have nevertheless been published for determining the parent thioamides group including those based on 1,3,4-thiadiazole [8] which have used reverse phase HPLC on a C18 column with a mobile phase of acetonitrile/acetate buffer (pH 4.7). Detection was by UV at the peak absorption maxima of these compounds (320 nm) and the HPLC separation took 8 min.…”

Section: Introductionmentioning

confidence: 99%

A simple HPLC method for determining 2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole in brain and plasma of animals: Application to a pharmacokinetic study

Raszewski

Juszczak²,

Lemieszek³

et al. 2014

Acta Chromatographica

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Summary. The development, optimization, and validation of a new high-performance liquid chromatography ultraviolet (HPLC-UV) method is presented for determining 2-(3-chlorophenyloamino)-5-(2,4-dihydroxy-phenyl)-1,3,4-thiadiazole (ClABT) in biological samples of rat plasma and brain tissue. ClABT was extracted directly from a plasma supernatant fraction following protein precipitation with acetonitrile and high speed centrifugation. Reverse phase HPLC separation was performed using an ODS-2 Hypersil column with the mobile phase consisting of 0.05 M triethylammonium phosphate buffer solution in acetonitrile and methanol (120:280:600, v/v/v), at room temperature, 1.2 mL min −1 flow rate, and UV-diode-array detection (DAD), at 335 nm. A linear response was obtained between 12.5 and 2000 ng mL −1 at analytically acceptable levels of precision (intra/inter-day) and accuracy. Mean recoveries ranged from 92.7% to 107.9%. It was concluded that the method was specific and precise and thus suitable for quantitative analysis in clinical pharmacokinetic studies of ClABT.

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“…Por outro lado, as principais técnicas analíticas para determinação e quantificação de tiadiazóis são cromatografia líquida de alta eficiência (HPLC) e eletroforese capilar de zona (CZE) ambos com detecção por UV. Contudo, a instrumentação cara, a não portabilidade e o tempo de preparo das amostras (extrações em série) são algumas dificuldades associadas a estes métodos (CHERNOV'YANTS; ALESHINA;BURYKIN, 2011;RASZEWSKI et al, 2014).Inicialmente foi estudada a proporção volumétrica ideal de etanol e água na composição do eletrólito suporte para possibilitar a miscibilidade completa das amostras, principalmente do óleo mineral. A seleção de eletrólito é um ponto chave para determinar o DMCT devido à natureza complexa das amostras analisadas nesta tese.…”

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Eletrodos impressos descartáveis: aplicações em amostras ambientais, alimentícias e combustíveis

Squissato¹

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Chromatographic and electrophoretic determination of thioamides based on thiazole, 1,3,4-thiadiazole, 1,2,4-triazole, and tetrazole

Cited by 4 publications

References 10 publications

Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex

Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex

A simple HPLC method for determining 2-(3-chlorophenyloamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole in brain and plasma of animals: Application to a pharmacokinetic study

Eletrodos impressos descartáveis: aplicações em amostras ambientais, alimentícias e combustíveis

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