Chromatographic analysis of carbamazepine binding to human serum albumin

Kim, Hee Seung; Mallik, Rangan; Hage, David S.

doi:10.1016/j.jchromb.2006.03.062

Cited by 40 publications

(36 citation statements)

References 37 publications

(65 reference statements)

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“…This interaction implies that the simultaneous binding of two ligands induces conformational changes of the protein, in addition to other factors such as pH, temperature and ionic strength 81,82 . To date, allosteric interactions have been reported to affect the binding equilibrium between HSA and endogenous or exogenous compounds, such as fatty acids, heme, carbamazepine and verapamil 83,84,85,86 .…”

Section: Stereoselectivity Of Plasma Protein Binding To Chiral Drugsmentioning

confidence: 99%

Stereoselective binding of chiral drugs to plasma proteins

et al. 2013

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Chiral drugs show distinct biochemical and pharmacological behaviors in the human body. The binding of chiral drugs to plasma proteins usually exhibits stereoselectivity, which has a far-reaching influence on their pharmacological activities and pharmacokinetic profiles. In this review, the stereoselective binding of chiral drugs to human serum albumin (HSA), α1-acid glycoprotein (AGP) and lipoprotein, three most important proteins in human plasma, are detailed. Furthermore, the application of AGP variants and recombinant fragments of HSA for studying enantiomer binding properties is also discussed. Apart from the stereoselectivity of enantiomer-protein binding, enantiomer-enantiomer interactions that may induce allosteric effects are also described. Additionally, the techniques and methods used to determine drug-protein binding parameters are briefly reviewed.

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Section: Stereoselectivity Of Plasma Protein Binding To Chiral Drugsmentioning

confidence: 99%

Stereoselective binding of chiral drugs to plasma proteins

et al. 2013

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“…Drug binding to HSA has been studied by numerous methods including immobilized affinity chromatography, equilibrium dialysis, affinity capillary electrophoresis, ultra filtration and ultracentrifugation [4][5][6][7][8][9][10][11]. However, these methods suffer from lack of sensitivity, long analysis time or reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods

Kandagal

Kalanur

Manjunatha

et al. 2008

Journal of Pharmaceutical and Biomedical Analysis

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“…This led to the identification of other site-selective probes that could be used for either HSA or AGP [50–52,60,76,103–105]. Some applications that followed included the development of affinity maps for drugs on these proteins [7,22,106,107] and reports that examined how modifications of these proteins affected local drug interactions at given sites [22,108–110]. …”

Section: Zonal Elutionmentioning

confidence: 99%

Analysis of stereoselective drug interactions with serum proteins by high-performance affinity chromatography: A historical perspective

Zhao

Hage

2017

Journal of Pharmaceutical and Biomedical Analysis

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The interactions of drugs with serum proteins are often stereoselective and can affect the distribution, activity, toxicity and rate of excretion of these drugs in the body. A number of approaches based on affinity chromatography, and particularly high-performance affinity chromatography (HPAC), have been used as tools to study these interactions. This review describes the general principles of affinity chromatography and HPAC as related to their use in drug binding studies. The types of serum agents that have been examined with these methods are also discussed, including human serum albumin, α1-acid glycoprotein, and lipoproteins. This is followed by a description of the various formats based on affinity chromatography and HPAC that have been used to investigate drug interactions with serum proteins and the historical development for each of these formats. Specific techniques that are discussed include zonal elution, frontal analysis, and kinetic methods such as those that make use of band-broadening measurements, peak decay analysis, or ultrafast affinity extraction.

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Chromatographic analysis of carbamazepine binding to human serum albumin

Cited by 40 publications

References 37 publications

Stereoselective binding of chiral drugs to plasma proteins

Stereoselective binding of chiral drugs to plasma proteins

Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods

Analysis of stereoselective drug interactions with serum proteins by high-performance affinity chromatography: A historical perspective

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