Chromatin Modifier EP400 Regulates Oocyte Quality and Zygotic Genome Activation in Mice
Qing Tian,
Ying Yin,
Yu Tian
et al.
Abstract:Epigenetic modifiers that accumulate in oocytes, play a crucial role in steering the developmental program of cleavage embryos and initiating life. However, the identification of key maternal epigenetic regulators remains elusive. In the findings, the essential role of maternal Ep400, a chaperone for H3.3, in oocyte quality and early embryo development in mice is highlighted. Depletion of Ep400 in oocytes resulted in a decline in oocyte quality and abnormalities in fertilization. Preimplantation embryos lackin… Show more
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