2005
DOI: 10.1016/j.ejca.2005.08.010
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Chromatin modifier enzymes, the histone code and cancer

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Cited by 289 publications
(222 citation statements)
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References 247 publications
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“…1 Furthermore, epigenetic analyses are of interest since epigenetic therapy is emerging as a valuable and effective treatment approach for peripheral T-cell lymphomas and is also envisaged for Bcell and Hodgkin's lymphomas. [2][3][4][5] There are different sets of epigenetic instructions involved in the regulation of gene expression.…”
Section: Introductionmentioning
confidence: 99%
“…1 Furthermore, epigenetic analyses are of interest since epigenetic therapy is emerging as a valuable and effective treatment approach for peripheral T-cell lymphomas and is also envisaged for Bcell and Hodgkin's lymphomas. [2][3][4][5] There are different sets of epigenetic instructions involved in the regulation of gene expression.…”
Section: Introductionmentioning
confidence: 99%
“…Alternatively, it might be an intrinsic characteristic of the yeast-display scFv library to generate scFv with preferential affinity for conformational epitopes (Weaver-Feldhaus et al, 2005). In either case, the ability of an affinity reagent to distinguish subtle conformational changes is a desirable characteristic for the accurate detection of biomarkers that often result from structural modifications of normal proteins through cleavage, aberrant transcriptions or post-translational modifications (Mahlknecht and Hoelzer, 2000;Brinkman, 2004;Venables, 2004;Kalnina et al, 2005;Santos-Rosa and Caldas, 2005).…”
Section: Discussionmentioning
confidence: 99%
“…Both epigenetic processes appear to act jointly to regulate gene expression and the densely methylated DNA associated with transcriptionally inactive chromatin usually contains hypoacetylated histones. [40][41][42] Preclinical studies have shown that DNA methylation and histone deacetylation promote tumorigenesis and cancer progression in some entities and that their inhibition strongly suppresses cancer growth. 43 Hypomethylating agents, such as 5-azadeoxycytidine, are specific inhibitors of the DNA methyltransferase resulting in promoter hypomethylation and concomitant reexpression of tumor suppressor genes and miRNAs.…”
Section: Micrornas As Epigenetic Targetsmentioning
confidence: 99%